7KIG
| Crystal structure of the MarR family transcriptional regulator from Variovorax paradoxus bound to Indole-3-butyric acid | 分子名称: | 3-INDOLEBUTYRIC ACID, SULFATE ION, Transcriptional regulator, ... | 著者 | Walton, W.G, Redinbo, M.R, Dangl, J.L. | 登録日 | 2020-10-23 | 公開日 | 2021-12-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome. Nat Microbiol, 7, 2022
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8CSC
| WbbB D232N-Kdo adduct | 分子名称: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, CHLORIDE ION, CYTIDINE-5'-MONOPHOSPHATE, ... | 著者 | Forrester, T.J.B, Kimber, M.S. | 登録日 | 2022-05-12 | 公開日 | 2022-11-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The retaining beta-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step. Nat Commun, 13, 2022
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8DI0
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8CSB
| WbbB D232N in complex with CMP-beta-Kdo | 分子名称: | CYTIDINE 5'-MONOPHOSPHATE 3-DEOXY-BETA-D-GULO-OCT-2-ULO-PYRANOSONIC ACID, CYTIDINE-5'-MONOPHOSPHATE, N-acetyl glucosaminyl transferase, ... | 著者 | Forrester, T.J.B, Kimber, M.S. | 登録日 | 2022-05-12 | 公開日 | 2022-11-09 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | The retaining beta-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step. Nat Commun, 13, 2022
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8PF4
| Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-methyl-1-(3-phenylpropyl)piperazin-1-ium | 分子名称: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Exertier, C, Ilari, A, Fiorillo, A, Antonelli, L. | 登録日 | 2023-06-15 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis. J.Med.Chem., 67, 2024
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7C87
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8DFV
| Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex IIa | 分子名称: | CALCIUM ION, Endoribonuclease Dcr-1, Loquacious, ... | 著者 | Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. | 登録日 | 2022-06-22 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
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6U4T
| Carbonic anhydrase 9 in complex with SB4197 | 分子名称: | 4-methyl-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione, Carbonic anhydrase 2, ZINC ION | 著者 | Murray, A.B, Lomelino, C.L, McKenna, R. | 登録日 | 2019-08-26 | 公開日 | 2020-01-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.356 Å) | 主引用文献 | "A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. J.Med.Chem., 63, 2020
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7KXS
| Computational design of constitutively active cGAS | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION | 著者 | Dowling, Q, Volkman, H.E, Gray, E.E, Ovchinnikov, S, Cambier, S, Bera, A.K, Bick, M, Kang, A, Stetson, D.B, King, N.P. | 登録日 | 2020-12-04 | 公開日 | 2021-12-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Computational design of constitutively active cGAS. Nat.Struct.Mol.Biol., 30, 2023
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8DG7
| Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex III | 分子名称: | Endoribonuclease Dcr-1, Loquacious, isoform B, ... | 著者 | Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. | 登録日 | 2022-06-23 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
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6U4Y
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7QY0
| X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | 著者 | Dahms, S.O, Brandstetter, H, Pautsch, A. | 登録日 | 2022-01-27 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
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7KYM
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7QY1
| X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyridin-2-yl]piperazin-1-ium-1-yl]propanoate, CALCIUM ION, ... | 著者 | Dahms, S.O, Brandstetter, H, Pautsch, A. | 登録日 | 2022-01-27 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
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8DGJ
| Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex Ib | 分子名称: | Endoribonuclease Dcr-1, Loquacious, isoform B | 著者 | Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. | 登録日 | 2022-06-23 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (4.02 Å) | 主引用文献 | Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
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8DGI
| Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex Ia | 分子名称: | Endoribonuclease Dcr-1, Loquacious, isoform B | 著者 | Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. | 登録日 | 2022-06-23 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
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7KZH
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6U7H
| Cryo-EM structure of the HCoV-229E spike glycoprotein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, Z, Benlekbir, S, Rubinstein, J.L, Rini, J.M. | 登録日 | 2019-09-02 | 公開日 | 2019-11-13 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | The human coronavirus HCoV-229E S-protein structure and receptor binding. Elife, 8, 2019
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7KUW
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8DG5
| Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex IIb | 分子名称: | Endoribonuclease Dcr-1, Loquacious, isoform B, ... | 著者 | Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. | 登録日 | 2022-06-23 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
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6U8X
| Crystal structure of DNMT3B-DNMT3L in complex with CpApG DNA | 分子名称: | CpApG DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | 著者 | Gao, L, Song, J. | 登録日 | 2019-09-06 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.95063877 Å) | 主引用文献 | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
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7L9T
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7LDQ
| Crystal structure of putative NAD(P)H-flavin oxidoreductase from Haemophilus influenzae R2846 | 分子名称: | ACETIC ACID, CALCIUM ION, CHLORIDE ION, ... | 著者 | Maltseva, N, Kim, Y, Endres, M, Crofts, T, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-01-13 | 公開日 | 2021-01-27 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Crystal structure of putative NAD(P)H-flavin oxidoreductase from Haemophilus influenzae R2846 To Be Published
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7LF9
| Structure of Hyperglycosylated Human IgG1 Fc (Fc329) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc329), ... | 著者 | Fields, J.K, Sundberg, E.J. | 登録日 | 2021-01-15 | 公開日 | 2021-01-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions To Be Published
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8D12
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