3LFC
 
 | | Human p38 MAP Kinase in Complex with RL99 | | 分子名称: | (4-{5-[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}carbamoyl)amino]-3-tert-butyl-1H-pyrazol-1-yl}phenyl)acetic acid, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | | 著者 | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | | 登録日 | 2010-01-16 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha
To be Published
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5C35
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2EBB
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2EET
 | | Guanine Riboswitch A21G, U75C mutant bound to hypoxanthine | | 分子名称: | ACETATE ION, COBALT HEXAMMINE(III), Guanine Riboswitch, ... | | 著者 | Gilbert, S.D, Edwards, A.L, Batey, R.T. | | 登録日 | 2007-02-18 | | 公開日 | 2007-11-13 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Mutational analysis of the purine riboswitch aptamer domain
Biochemistry, 46, 2007
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2EC8
 | | Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor | | 著者 | Yuzawa, S, Opatowsky, Y, Zhang, Z, Mandiyan, V, Lax, I, Schlessinger, J. | | 登録日 | 2007-02-11 | | 公開日 | 2007-08-07 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130, 2007
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2EEU
 | | Guanine riboswitch U22A, A52U mutant bound to hypoxanthine | | 分子名称: | ACETATE ION, COBALT HEXAMMINE(III), Guanine riboswitch, ... | | 著者 | Gilbert, S.D, Love, C.E, Batey, R.T. | | 登録日 | 2007-02-19 | | 公開日 | 2007-11-13 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Mutational analysis of the purine riboswitch aptamer domain
Biochemistry, 46, 2007
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2EEZ
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7JQG
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2EHH
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2EIU
 | | Crystal Structure of a Putative protein (AQ1627) from Aquifex aeolicus | | 分子名称: | Hypothetical protein aq_1627 | | 著者 | Kumarevel, T.S, Karthe, P, Nakano, N, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-03-13 | | 公開日 | 2007-09-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of a Putative protein (AQ1627) from Aquifex aeolicus
To be Published
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3LFF
 | | Human p38 MAP Kinase in Complex with RL166 | | 分子名称: | (4-{3-tert-butyl-5-[(1,3-thiazol-2-ylcarbamoyl)amino]-1H-pyrazol-1-yl}phenyl)acetic acid, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | | 著者 | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | | 登録日 | 2010-01-16 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha
To be Published
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2EBD
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4OLB
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2J2I
 | | Crystal Structure of the humab PIM1 in complex with LY333531 | | 分子名称: | (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, SULFATE ION | | 著者 | Debreczeni, J.E, Bullock, A.N, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, Knapp, S. | | 登録日 | 2006-08-16 | | 公開日 | 2007-02-13 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Proc. Natl. Acad. Sci. U.S.A., 104, 2007
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3LFE
 | | Human p38 MAP Kinase in Complex with RL116 | | 分子名称: | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(pyridin-4-ylmethoxy)ethyl]-1,3-thiazol-2-yl}urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | | 著者 | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | | 登録日 | 2010-01-16 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha
To be Published
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2R4G
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4NJ7
 | | PB1 Domain of AtARF7 - SeMet Derivative | | 分子名称: | Auxin response factor 7 | | 著者 | Korasick, D.A, Westfall, C.S, Lee, S.G, Nanao, M, Jez, J.M, Strader, L.C. | | 登録日 | 2013-11-08 | | 公開日 | 2014-03-26 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression.
Proc.Natl.Acad.Sci.USA, 111, 2014
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2EGI
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7KCO
 | | ROR gamma in complex with SCR2 and compound 3 | | 分子名称: | 1-[(2-chlorophenyl)methyl]-N-{[4-(methylsulfonyl)phenyl]methyl}-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-2'-carboxamide, GLYCEROL, Nuclear receptor ROR-gamma, ... | | 著者 | Durbin, J.D, Guo, S.Y, Stout, S.L, Clawson, D.K. | | 登録日 | 2020-10-06 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (ROR gamma t).
J.Med.Chem., 64, 2021
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3LFB
 | | Human p38 MAP Kinase in Complex with RL98 | | 分子名称: | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(1,3-thiazol-2-yl)urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | | 著者 | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | | 登録日 | 2010-01-16 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha
To be Published
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2EF0
 | | Crystal structure of ornithine carbamoyltransferase from thermus thermophilus | | 分子名称: | MAGNESIUM ION, Ornithine carbamoyltransferase, SODIUM ION | | 著者 | Karthe, P, Kumarevel, T.S, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-02-19 | | 公開日 | 2007-04-13 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of ornithine carbamoyltransferase from thermus thermophilus
To be Published
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2ELA
 | | Crystal Structure of the PTB domain of human APPL1 | | 分子名称: | Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 | | 著者 | Li, J, Mao, X, Dong, L.Q, Liu, F, Tong, L. | | 登録日 | 2007-03-27 | | 公開日 | 2007-05-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures of the BAR-PH and PTB Domains of Human APPL1
Structure, 15, 2007
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4NRT
 | | Human Norovirus polymerase bound to Compound 6 (suramin derivative) | | 分子名称: | 4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid, hNV-RdRp | | 著者 | Croci, R, Pezzullo, M, Tarantino, D, Mastrangelo, E, Milani, M, Bolognesi, M. | | 登録日 | 2013-11-27 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.022 Å) | | 主引用文献 | Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
Plos One, 9, 2014
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4NJ6
 | | PB1 Domain of AtARF7 | | 分子名称: | Auxin response factor 7 | | 著者 | Korasick, D.A, Westfall, C.S, Lee, S.G, Nanao, M, Jez, J.M, Strader, L.C. | | 登録日 | 2013-11-08 | | 公開日 | 2014-03-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4A9Y
 | | P38ALPHA MAP KINASE BOUND TO CMPD 8 | | 分子名称: | MITOGEN-ACTIVATED PROTEIN KINASE 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE | | 著者 | Gerhardt, S, Hargreaves, D. | | 登録日 | 2011-11-29 | | 公開日 | 2012-05-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases
Bioorg.Med.Chem.Lett., 22, 2012
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