PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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4L8R	Structure of mrna stem-loop, human stem-loop binding protein and 3'hexo ternary complex 分子名称: 3'-5' exoribonuclease 1, HISTONE MRNA STEM-LOOP, Histone RNA hairpin-binding protein 著者 Tan, D, Tong, L. 登録日 2013-06-17 公開日 2013-07-10 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of Histone Mrna Stem-Loop, Human Stem-Loop Binding Protein, and 3'Hexo Ternary Complex. Science, 339, 2013
1SWI	GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A COMPLEXED WITH BENZENE 分子名称: BENZENE, GCN4P1 著者 Gonzalez, L, Plecs, J, Alber, T. 登録日 1996-05-09 公開日 1996-11-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 An engineered allosteric switch in leucine-zipper oligomerization. Nat.Struct.Biol., 3, 1996
5IJO	Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205) 分子名称: Nuclear pore complex protein Nup155, Nuclear pore complex protein Nup205, Nuclear pore complex protein Nup93, ... 著者 Kosinski, J, Mosalaganti, S, von Appen, A, Beck, M. 登録日 2016-03-02 公開日 2016-04-27 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (21.4 Å) 主引用文献 Molecular architecture of the inner ring scaffold of the human nuclear pore complex. Science, 352, 2016
3VBY	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 分子名称: IMIDAZOLE, Serine/threonine-protein kinase pim-1, furan-2-yl(1H-indol-3-yl)methanone 著者 Liu, J. 登録日 2012-01-02 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
1ZKA	NF-kB RelB forms an intertwined homodimer, Y300S mutant 分子名称: Transcription factor RelB 著者 Huang, D.B, Vu, D, Ghosh, G. 登録日 2005-05-02 公開日 2005-05-10 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 NF-kappaB RelB forms an intertwined homodimer. Structure, 13, 2005
2H6N	Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex 分子名称: Histone H3 K4-Me2 9-residue peptide, WD-repeat protein 5 著者 Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. 登録日 2006-05-31 公開日 2006-07-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
3VBW	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 分子名称: 1,3-dioxo-2,3-dihydro-1H-indene-2-carbonitrile, Serine/threonine-protein kinase pim-1 著者 Liu, J. 登録日 2012-01-02 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
2GNQ	Structure of wdr5 分子名称: CHLORIDE ION, WD-repeat protein 5 著者 Min, J, Schuetz, A, Allali-Hassani, A, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2006-04-10 公開日 2006-06-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
2NN6	Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40 分子名称: 3'-5' exoribonuclease CSL4 homolog, Exosome complex exonuclease RRP4, Exosome complex exonuclease RRP40, ... 著者 Lima, C.D. 登録日 2006-10-23 公開日 2006-12-26 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell(Cambridge,Mass.), 127, 2006
1JH7	Semi-reduced Inhibitor-bound Cyclic Nucleotide Phosphodiesterase from Arabidopsis thaliana 分子名称: SULFATE ION, URIDINE-2',3'-VANADATE, cyclic phosphodiesterase 著者 Hofmann, A, Grella, M, Botos, I, Filipowicz, W, Wlodawer, A. 登録日 2001-06-27 公開日 2002-02-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana. J.Biol.Chem., 277, 2002
1JID	Human SRP19 in complex with helix 6 of Human SRP RNA 分子名称: HELIX 6 OF HUMAN SRP RNA, MAGNESIUM ION, SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN 著者 Wild, K, Sinning, I, Cusack, S. 登録日 2001-07-02 公開日 2001-10-19 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of an early protein-RNA assembly complex of the signal recognition particle. Science, 294, 2001
7Z6I	Crystal structure of p38alpha C162S in complex with SB20358 and CAS 2094667-81-7 (behind catalytic site; Y35 in), P 21 21 21 分子名称: 4-[4-(4-fluorophenyl)-2-[4-[methyl(oxidanyl)-$l^{3}-sulfanyl]phenyl]-1~{H}-imidazol-5-yl]pyridine, Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)benzenesulfonamide 著者 Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R. 登録日 2022-03-11 公開日 2023-06-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway. Nat Commun, 14, 2023
7Z9T	Crystal structure of p38alpha C162S in complex with ATPgS and CAS 2094667-81-7 (in catalytic site, Y35 out), P 1 21 1 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)benzenesulfonamide 著者 Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R. 登録日 2022-03-21 公開日 2023-06-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway. Nat Commun, 14, 2023
2H6Q	Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex 分子名称: Histone H3 K4-Me3 9-residue peptide, WD-repeat protein 5 著者 Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. 登録日 2006-06-01 公開日 2006-07-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
6CKA	Crystal Structure of Paratox 分子名称: Paratox 著者 Prehna, G. 登録日 2018-02-27 公開日 2018-11-14 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (1.559 Å) 主引用文献 The conserved mosaic prophage protein paratox inhibits the natural competence regulator ComR in Streptococcus. Sci Rep, 8, 2018
1JJ2	Fully Refined Crystal Structure of the Haloarcula marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution 分子名称: 23S RRNA, 5S RRNA, CADMIUM ION, ... 著者 Klein, D.J, Schmeing, T.M, Moore, P.B, Steitz, T.A. 登録日 2001-07-03 公開日 2001-08-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The kink-turn: a new RNA secondary structure motif. EMBO J., 20, 2001
4L55	X-ray structure of the adduct between bovine pancreatic ribonuclease and AziRu 分子名称: RUTHENIUM ION, Ribonuclease pancreatic 著者 Vergara, A, Russo Krauss, I, Merlino, A. 登録日 2013-06-10 公開日 2014-01-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Investigating the ruthenium metalation of proteins: X-ray structure and Raman microspectroscopy of the complex between RNase A and AziRu. Inorg.Chem., 52, 2013
2H9N	WDR5 in complex with monomethylated H3K4 peptide 分子名称: H3 histone, WD-repeat protein 5 著者 Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2006-06-10 公開日 2006-08-01 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
1J3U	Crystal structure of aspartase from Bacillus sp. YM55-1 分子名称: aspartase 著者 Fujii, T, Sakai, H, Kawata, Y, Hata, Y. 登録日 2003-02-16 公開日 2003-05-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of Thermostable Aspartase from Bacillus sp. YM55-1: Structure-based Exploration of Functional Sites in the Aspartase Family J.Mol.Biol., 328, 2003
2H9M	WDR5 in complex with unmodified H3K4 peptide 分子名称: H3 histone, WD-repeat protein 5 著者 Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2006-06-10 公開日 2006-08-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
1YXT	Crystal Structure of Kinase Pim1 in complex with AMPPNP 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proto-oncogene serine/threonine-protein kinase Pim-1 著者 Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. 登録日 2005-02-22 公開日 2005-04-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma. J.Mol.Biol., 348, 2005
2H9P	WDR5 in complex with trimethylated H3K4 peptide 分子名称: H3 histone, WD-repeat protein 5 著者 Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2006-06-10 公開日 2006-08-01 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
3UMW	Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one 分子名称: (2Z)-2-(1H-indazol-3-ylmethylidene)-6-methoxy-7-(piperazin-1-ylmethyl)-1-benzofuran-3(2H)-one, GLYCEROL, Proto-oncogene serine/threonine-protein kinase pim-1, ... 著者 Parker, L.J, Handa, N, Yokoyama, S. 登録日 2011-11-14 公開日 2012-10-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound. J.Med.Chem., 55, 2012
3UIX	Crystal structure of Pim1 kinase in complex with small molecule inhibitor 分子名称: 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol, CALCIUM ION, CHLORIDE ION, ... 著者 Parker, L.J. 登録日 2011-11-06 公開日 2012-04-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A novel pim-1 kinase inhibitor targeting residues that bind the substrate Peptide. J.Mol.Biol., 417, 2012
1I0I	ANALYSIS OF AN INVARIANT ASPARTIC ACID IN HPRTS-GLUTAMINE MUTANT 分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, ... 著者 Canyuk, B, Focia, P.J, Eakin, A.E. 登録日 2001-01-29 公開日 2002-05-29 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography. Biochemistry, 40, 2001

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