1I0I

ANALYSIS OF AN INVARIANT ASPARTIC ACID IN HPRTS-GLUTAMINE MUTANT

Summary for 1I0I
Related1I0L 1I13 1I14 1tc1 1tc2
DescriptorHYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, ... (5 entities in total)
Functional Keywordsphosphoribosyltransferase, nucleotide metabolism, purine salvage, ternary complex, catalytic base, transferase
Biological sourceTrypanosoma cruzi
Cellular locationCytoplasm : Q27796
Total number of polymer chains2
Total formula weight52224.32
Authors
Canyuk, B.,Focia, P.J.,Eakin, A.E. (deposition date: 2001-01-29, release date: 2002-05-29, Last modification date: 2020-07-29)
Primary citationCanyuk, B.,Eakin, A.E.,Focia, P.J.
The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography.
Biochemistry, 40:2754-2765, 2001
PubMed: 11258886
DOI: 110.1021/bi001195q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.06 Å)
Structure validation
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PDB entries from 2021-06-16