1I0I

ANALYSIS OF AN INVARIANT ASPARTIC ACID IN HPRTS-GLUTAMINE MUTANT

Summary for 1I0I

• Entry DOI: 10.2210/pdb1i0i/pdb
• Related: 1I0L 1I13 1I14 1tc1 1tc2
• Descriptor: HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, ... (5 entities in total)
• Functional Keywords: phosphoribosyltransferase, nucleotide metabolism, purine salvage, ternary complex, catalytic base, transferase
• Biological source: Trypanosoma cruzi
• Cellular location: Cytoplasm : Q27796
• Total number of polymer chains: 2
• Total formula weight: 52224.32

Authors

Canyuk, B.,Focia, P.J.,Eakin, A.E. (deposition date: 2001-01-29, release date: 2002-05-29, Last modification date: 2023-08-09)

• Primary citation: Canyuk, B.,Focia, P.J.,Eakin, A.E.; The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography.; Biochemistry, 40:2754-2765, 2001; PubMed: 11258886; DOI: 10.1021/bi001195q

Experimental method

X-RAY DIFFRACTION (2.06 Å)