PDB: 47065 件ウェブページステータス検索Chemie searchBIRD

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4GPJ	Crystal Structure of the first bromodomain of human BRD4 in complex with a isoxazolylbenzimidazole ligand 分子名称: (1R)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-phenyl-2,3-dihydro-1H-inden-1-ol, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... 著者 Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, Heightman, T.D, Brennan, P, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2012-08-21 公開日 2012-10-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains. Medchemcomm, 4, 2013
4HBW	Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazoline ligand 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-ethyl-3-methyl-2-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide, ... 著者 Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Fish, P.V, Bunnage, M.E, Cook, A.S, Owen, D.R, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2012-09-28 公開日 2012-10-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit. J.Med.Chem., 55, 2012
5EH1	Crystal structure of the extracellular part of receptor 2 of human interferon gamma 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, GLYCEROL, ... 著者 Kolenko, P, Mikulecky, P, Zahradnik, J, Dohnalek, J, Koval, T, Cerny, J, Necasova, I, Schneider, B. 登録日 2015-10-27 公開日 2016-08-17 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of human interferon-gamma receptor 2 reveals the structural basis for receptor specificity. Acta Crystallogr D Struct Biol, 72, 2016
4GQE	Structure of rat neuronal nitric oxide synthase heme domain in complex with (5E)-5-[(N-tert-butoxycarbamimidoyl)imino]-L-norvaline 分子名称: (5E)-5-[(N-tert-butoxycarbamimidoyl)imino]-L-norvaline, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... 著者 Li, H, Poulos, T.L. 登録日 2012-08-22 公開日 2013-05-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction Biochemistry, 52, 2013
3BZ3	Crystal Structure Analysis of Focal Adhesion Kinase with a Methanesulfonamide Diaminopyrimidine Inhibitor 分子名称: Focal adhesion kinase 1, N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide 著者 Vajdos, F, Marr, E. 登録日 2008-01-17 公開日 2008-04-01 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res., 68, 2008
3CS0	Crystal structure of DegP24 分子名称: Periplasmic serine endoprotease DegP, pentapeptide 著者 Krojer, T, Sawa, J, Schaefer, E, Saibil, H.R, Ehrmann, M, Clausen, T. 登録日 2008-04-08 公開日 2008-05-27 最終更新日 2019-11-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for the regulated protease and chaperone function of DegP Nature, 453, 2008
4HD7	Crystal Structure of Tyrosinase from Bacillus megaterium V218G mutant soaked in CuSO4 分子名称: COPPER (II) ION, Tyrosinase 著者 Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. 登録日 2012-10-02 公開日 2013-01-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Influencing the monophenolase/diphenolase activity ratio in tyrosinase. Biochim.Biophys.Acta, 1834, 2013
5EQG	Human GLUT1 in complex with inhibitor (2~{S})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide 分子名称: (2~{S})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide, Solute carrier family 2, facilitated glucose transporter member 1 著者 Kapoor, K, Finer-Moore, J, Pedersen, B.P, Caboni, L, Waight, A.B, Hillig, R, Bringmann, P, Heisler, I, Muller, T, Siebeneicher, H, Stroud, R.M. 登録日 2015-11-12 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides. Proc.Natl.Acad.Sci.USA, 113, 2016
5EQL	Isoform-specific inhibition of SUMO-dependent protein-protein interactions 分子名称: SUMO-Affirmer-S2D5, Small ubiquitin-related modifier 2 著者 Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A. 登録日 2015-11-13 公開日 2016-11-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology. Sci Signal, 10, 2017
1PQN	dominant negative human hDim1 (hDim1 1-128) 分子名称: Spliceosomal U5 snRNP-specific 15 kDa protein 著者 Zhang, Y.Z, Cheng, H, Gould, K.L, Golemis, E.A, Roder, H. 登録日 2003-06-18 公開日 2003-08-26 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure, stability and function of hDim1 investigated by NMR, circular dichroism and mutational analysis Biochemistry, 42, 2003
4GSY	Crystal structure of thymidylate kinase from Staphylococcus aureus bound to inhibitor. 分子名称: 4-{[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl}-2-[3-(trifluoromethyl)phenoxy]benzoic acid, Thymidylate kinase 著者 Larsen, N.A, Olivier, N.B. 登録日 2012-08-28 公開日 2012-10-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK). J.Med.Chem., 55, 2012
8VJ6	GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 1 分子名称: 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline, Isoform Flip of Glutamate receptor 2 著者 Hale, W.D, Montano Romero, A, Huganir, R.L, Twomey, E.C. 登録日 2024-01-05 公開日 2024-06-05 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Allosteric competition and inhibition in AMPA receptors. Nat.Struct.Mol.Biol., 2024
3C05	Crystal structure of Acostatin from Agkistrodon Contortrix Contortrix 分子名称: Disintegrin acostatin alpha, Disintegrin acostatin-beta, SULFATE ION 著者 Moiseeva, N, Bau, R, Allaire, M. 登録日 2008-01-18 公開日 2008-04-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of acostatin, a dimeric disintegrin from southern copperhead (Agkistrodon contortrix contortrix) at 1.7 A resolution Acta Crystallogr.,Sect.D, 64, 2008
1Q0W	Solution structure of Vps27 amino-terminal UIM-ubiquitin complex 分子名称: Ubiquitin, Vacuolar protein sorting-associated protein VPS27 著者 Swanson, K.A, Kang, R.S, Stamenova, S.D, Hicke, L, Radhakrishnan, I. 登録日 2003-07-17 公開日 2003-10-07 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution Structure of Vps27 UIM-Ubiquitin Complex Important for Endosomal Sorting and Receptor Downregulation Embo J., 22, 2003
5AM1	ligand complex structure of soluble epoxide hydrolase 分子名称: 4-oxidanylidene-N-[(1S,2R)-2-phenylcyclopropyl]spiro[3H-chromene-2,4'-piperidine]-1'-carboxamide, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
3CU7	Human Complement Component 5 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ... 著者 Fredslund, F, Andersen, G.R. 登録日 2008-04-16 公開日 2008-06-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.105 Å) 主引用文献 Structure of and influence of a tick complement inhibitor on human complement component 5 Nat.Immunol., 9, 2008
2V2M	Mutant (E53,56,57,60Q) recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions 分子名称: CADMIUM ION, FERRITIN LIGHT CHAIN, GLYCEROL, ... 著者 De Val, N, Declercq, J.P. 登録日 2007-06-06 公開日 2008-06-24 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural Analysis of Haemin Demetallation by L-Chain Apoferritins J.Inorg.Biochem., 112, 2012
1Q2D	Crystal Structure of Tetrahymena GCN5 With Bound Coenzyme A and a 19-residue p53 peptide 分子名称: 19-mer peptide fragment from p53 Tumor Suppressor, COENZYME A, histone acetyltransferase GCN5 著者 Poux, A.N, Marmorstein, R. 登録日 2003-07-24 公開日 2004-08-03 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Molecular basis for GCN5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates Biochemistry, 42, 2003
2UVU	Crystal structures of mutant Dpo4 DNA polymerases with 8-oxoG containing DNA template-primer constructs 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*A)-3', 5'-D(*TP*CP*AP*CP*8OGP*GP*AP*AP*TP*CP *CP*TP*TP*CP*CP*CP*CP*C)-3', ... 著者 Irimia, A, Egli, M. 登録日 2007-03-14 公開日 2007-05-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Hydrogen Bonding of 7,8-Dihydro-8-Oxodeoxyguanosine with a Charged Residue in the Little Finger Domain Determines Miscoding Events in Sulfolobus Solfataricus DNA Polymerase Dpo4. J.Biol.Chem., 282, 2007
1PTJ	Crystal structure analysis of the DI and DIII complex of transhydrogenase with a thio-nicotinamide nucleotide analogue 分子名称: GLYCEROL, NAD(P) transhydrogenase subunit alpha part 1, NAD(P) transhydrogenase subunit beta, ... 著者 Singh, A, Venning, J.D, Quirk, P.G, van Boxel, G.I, Rodrigues, D.J, White, S.A, Jackson, J.B. 登録日 2003-06-23 公開日 2003-10-07 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Interactions between transhydrogenase and thio-nicotinamide analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation J.Biol.Chem., 278, 2003
7R5W	Crystal structure of YTHDF2 with compound YLI_DF_029 分子名称: 6-cyclopropyl-1H-pyrimidine-2,4-dione, CHLORIDE ION, GLYCEROL, ... 著者 Nai, F, Li, Y, Caflisch, A. 登録日 2022-02-11 公開日 2022-03-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
3C2W	Crystal structure of the photosensory core domain of P. aeruginosa bacteriophytochrome PaBphP in the Pfr state 分子名称: BILIVERDINE IX ALPHA, Bacteriophytochrome 著者 Yang, X, Kuk, J, Moffat, K. 登録日 2008-01-25 公開日 2008-09-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of Pseudomonas aeruginosa bacteriophytochrome: photoconversion and signal transduction. Proc.Natl.Acad.Sci.USA, 105, 2008
2UZZ	X-ray structure of N-methyl-L-tryptophan oxidase (MTOX) 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, N-METHYL-L-TRYPTOPHAN OXIDASE, SODIUM ION 著者 Ilari, A, Fiorillo, A, Franceschini, S, Bonamore, A, Colotti, G, Boffi, A. 登録日 2007-05-03 公開日 2008-01-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The X-Ray Structure of N-Methyltryptophan Oxidase Reveals the Structural Determinants of Substrate Specificity. Proteins, 71, 2008
5EEY	RADIATION DAMAGE TO THE TRAP-RNA COMPLEX: DOSE (DWD) 11.6 MGy 分子名称: (GAGUU)10GAG 53-NUCLEOTIDE RNA, TRYPTOPHAN, Transcription attenuation protein MtrB 著者 Bury, C.S, McGeehan, J.E, Garman, E.F, Shevtsov, M.B. 登録日 2015-10-23 公開日 2016-05-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 RNA protects a nucleoprotein complex against radiation damage. Acta Crystallogr D Struct Biol, 72, 2016
3CT6	Crystal structure of DhaM of L. lactis 分子名称: PTS-dependent dihydroxyacetone kinase, phosphotransferase subunit dhaM 著者 Zurbriggen, A. 登録日 2008-04-11 公開日 2008-10-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 X-ray Structures of the Three Lactococcus lactis Dihydroxyacetone Kinase Subunits and of a Transient Intersubunit Complex. J.Biol.Chem., 283, 2008

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