4GPJ
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![BU of 4gpj by Molmil](/molmil-images/mine/4gpj) | Crystal Structure of the first bromodomain of human BRD4 in complex with a isoxazolylbenzimidazole ligand | 分子名称: | (1R)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-phenyl-2,3-dihydro-1H-inden-1-ol, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, Heightman, T.D, Brennan, P, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2012-08-21 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains. Medchemcomm, 4, 2013
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4HBW
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![BU of 4hbw by Molmil](/molmil-images/mine/4hbw) | Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazoline ligand | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-ethyl-3-methyl-2-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide, ... | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Fish, P.V, Bunnage, M.E, Cook, A.S, Owen, D.R, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2012-09-28 | 公開日 | 2012-10-31 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit. J.Med.Chem., 55, 2012
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5EH1
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![BU of 5eh1 by Molmil](/molmil-images/mine/5eh1) | Crystal structure of the extracellular part of receptor 2 of human interferon gamma | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, GLYCEROL, ... | 著者 | Kolenko, P, Mikulecky, P, Zahradnik, J, Dohnalek, J, Koval, T, Cerny, J, Necasova, I, Schneider, B. | 登録日 | 2015-10-27 | 公開日 | 2016-08-17 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of human interferon-gamma receptor 2 reveals the structural basis for receptor specificity. Acta Crystallogr D Struct Biol, 72, 2016
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4GQE
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![BU of 4gqe by Molmil](/molmil-images/mine/4gqe) | Structure of rat neuronal nitric oxide synthase heme domain in complex with (5E)-5-[(N-tert-butoxycarbamimidoyl)imino]-L-norvaline | 分子名称: | (5E)-5-[(N-tert-butoxycarbamimidoyl)imino]-L-norvaline, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | 著者 | Li, H, Poulos, T.L. | 登録日 | 2012-08-22 | 公開日 | 2013-05-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction Biochemistry, 52, 2013
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3BZ3
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![BU of 3bz3 by Molmil](/molmil-images/mine/3bz3) | |
3CS0
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![BU of 3cs0 by Molmil](/molmil-images/mine/3cs0) | Crystal structure of DegP24 | 分子名称: | Periplasmic serine endoprotease DegP, pentapeptide | 著者 | Krojer, T, Sawa, J, Schaefer, E, Saibil, H.R, Ehrmann, M, Clausen, T. | 登録日 | 2008-04-08 | 公開日 | 2008-05-27 | 最終更新日 | 2019-11-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for the regulated protease and chaperone function of DegP Nature, 453, 2008
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4HD7
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![BU of 4hd7 by Molmil](/molmil-images/mine/4hd7) | Crystal Structure of Tyrosinase from Bacillus megaterium V218G mutant soaked in CuSO4 | 分子名称: | COPPER (II) ION, Tyrosinase | 著者 | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | 登録日 | 2012-10-02 | 公開日 | 2013-01-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Influencing the monophenolase/diphenolase activity ratio in tyrosinase. Biochim.Biophys.Acta, 1834, 2013
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5EQG
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![BU of 5eqg by Molmil](/molmil-images/mine/5eqg) | Human GLUT1 in complex with inhibitor (2~{S})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide | 分子名称: | (2~{S})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide, Solute carrier family 2, facilitated glucose transporter member 1 | 著者 | Kapoor, K, Finer-Moore, J, Pedersen, B.P, Caboni, L, Waight, A.B, Hillig, R, Bringmann, P, Heisler, I, Muller, T, Siebeneicher, H, Stroud, R.M. | 登録日 | 2015-11-12 | 公開日 | 2016-04-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides. Proc.Natl.Acad.Sci.USA, 113, 2016
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5EQL
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![BU of 5eql by Molmil](/molmil-images/mine/5eql) | Isoform-specific inhibition of SUMO-dependent protein-protein interactions | 分子名称: | SUMO-Affirmer-S2D5, Small ubiquitin-related modifier 2 | 著者 | Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A. | 登録日 | 2015-11-13 | 公開日 | 2016-11-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology. Sci Signal, 10, 2017
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1PQN
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![BU of 1pqn by Molmil](/molmil-images/mine/1pqn) | dominant negative human hDim1 (hDim1 1-128) | 分子名称: | Spliceosomal U5 snRNP-specific 15 kDa protein | 著者 | Zhang, Y.Z, Cheng, H, Gould, K.L, Golemis, E.A, Roder, H. | 登録日 | 2003-06-18 | 公開日 | 2003-08-26 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure, stability and function of hDim1 investigated by NMR, circular
dichroism and mutational analysis Biochemistry, 42, 2003
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4GSY
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![BU of 4gsy by Molmil](/molmil-images/mine/4gsy) | |
8VJ6
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![BU of 8vj6 by Molmil](/molmil-images/mine/8vj6) | GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 1 | 分子名称: | 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline, Isoform Flip of Glutamate receptor 2 | 著者 | Hale, W.D, Montano Romero, A, Huganir, R.L, Twomey, E.C. | 登録日 | 2024-01-05 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Allosteric competition and inhibition in AMPA receptors. Nat.Struct.Mol.Biol., 2024
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3C05
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![BU of 3c05 by Molmil](/molmil-images/mine/3c05) | Crystal structure of Acostatin from Agkistrodon Contortrix Contortrix | 分子名称: | Disintegrin acostatin alpha, Disintegrin acostatin-beta, SULFATE ION | 著者 | Moiseeva, N, Bau, R, Allaire, M. | 登録日 | 2008-01-18 | 公開日 | 2008-04-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of acostatin, a dimeric disintegrin from southern copperhead
(Agkistrodon contortrix contortrix) at 1.7 A resolution Acta Crystallogr.,Sect.D, 64, 2008
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1Q0W
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![BU of 1q0w by Molmil](/molmil-images/mine/1q0w) | Solution structure of Vps27 amino-terminal UIM-ubiquitin complex | 分子名称: | Ubiquitin, Vacuolar protein sorting-associated protein VPS27 | 著者 | Swanson, K.A, Kang, R.S, Stamenova, S.D, Hicke, L, Radhakrishnan, I. | 登録日 | 2003-07-17 | 公開日 | 2003-10-07 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of Vps27 UIM-Ubiquitin Complex Important for Endosomal Sorting and Receptor Downregulation Embo J., 22, 2003
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5AM1
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![BU of 5am1 by Molmil](/molmil-images/mine/5am1) | ligand complex structure of soluble epoxide hydrolase | 分子名称: | 4-oxidanylidene-N-[(1S,2R)-2-phenylcyclopropyl]spiro[3H-chromene-2,4'-piperidine]-1'-carboxamide, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... | 著者 | Oster, L, Tapani, S, Xue, Y, Kack, H. | 登録日 | 2015-03-08 | 公開日 | 2015-05-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
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3CU7
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![BU of 3cu7 by Molmil](/molmil-images/mine/3cu7) | Human Complement Component 5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ... | 著者 | Fredslund, F, Andersen, G.R. | 登録日 | 2008-04-16 | 公開日 | 2008-06-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.105 Å) | 主引用文献 | Structure of and influence of a tick complement inhibitor on human complement component 5 Nat.Immunol., 9, 2008
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2V2M
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![BU of 2v2m by Molmil](/molmil-images/mine/2v2m) | Mutant (E53,56,57,60Q) recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions | 分子名称: | CADMIUM ION, FERRITIN LIGHT CHAIN, GLYCEROL, ... | 著者 | De Val, N, Declercq, J.P. | 登録日 | 2007-06-06 | 公開日 | 2008-06-24 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural Analysis of Haemin Demetallation by L-Chain Apoferritins J.Inorg.Biochem., 112, 2012
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1Q2D
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![BU of 1q2d by Molmil](/molmil-images/mine/1q2d) | |
2UVU
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![BU of 2uvu by Molmil](/molmil-images/mine/2uvu) | |
1PTJ
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![BU of 1ptj by Molmil](/molmil-images/mine/1ptj) | Crystal structure analysis of the DI and DIII complex of transhydrogenase with a thio-nicotinamide nucleotide analogue | 分子名称: | GLYCEROL, NAD(P) transhydrogenase subunit alpha part 1, NAD(P) transhydrogenase subunit beta, ... | 著者 | Singh, A, Venning, J.D, Quirk, P.G, van Boxel, G.I, Rodrigues, D.J, White, S.A, Jackson, J.B. | 登録日 | 2003-06-23 | 公開日 | 2003-10-07 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Interactions between transhydrogenase and thio-nicotinamide analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation J.Biol.Chem., 278, 2003
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7R5W
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![BU of 7r5w by Molmil](/molmil-images/mine/7r5w) | Crystal structure of YTHDF2 with compound YLI_DF_029 | 分子名称: | 6-cyclopropyl-1H-pyrimidine-2,4-dione, CHLORIDE ION, GLYCEROL, ... | 著者 | Nai, F, Li, Y, Caflisch, A. | 登録日 | 2022-02-11 | 公開日 | 2022-03-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
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3C2W
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2UZZ
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![BU of 2uzz by Molmil](/molmil-images/mine/2uzz) | X-ray structure of N-methyl-L-tryptophan oxidase (MTOX) | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, N-METHYL-L-TRYPTOPHAN OXIDASE, SODIUM ION | 著者 | Ilari, A, Fiorillo, A, Franceschini, S, Bonamore, A, Colotti, G, Boffi, A. | 登録日 | 2007-05-03 | 公開日 | 2008-01-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The X-Ray Structure of N-Methyltryptophan Oxidase Reveals the Structural Determinants of Substrate Specificity. Proteins, 71, 2008
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5EEY
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![BU of 5eey by Molmil](/molmil-images/mine/5eey) | RADIATION DAMAGE TO THE TRAP-RNA COMPLEX: DOSE (DWD) 11.6 MGy | 分子名称: | (GAGUU)10GAG 53-NUCLEOTIDE RNA, TRYPTOPHAN, Transcription attenuation protein MtrB | 著者 | Bury, C.S, McGeehan, J.E, Garman, E.F, Shevtsov, M.B. | 登録日 | 2015-10-23 | 公開日 | 2016-05-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | RNA protects a nucleoprotein complex against radiation damage. Acta Crystallogr D Struct Biol, 72, 2016
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3CT6
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![BU of 3ct6 by Molmil](/molmil-images/mine/3ct6) | Crystal structure of DhaM of L. lactis | 分子名称: | PTS-dependent dihydroxyacetone kinase, phosphotransferase subunit dhaM | 著者 | Zurbriggen, A. | 登録日 | 2008-04-11 | 公開日 | 2008-10-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | X-ray Structures of the Three Lactococcus lactis Dihydroxyacetone Kinase Subunits and of a Transient Intersubunit Complex. J.Biol.Chem., 283, 2008
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