7XQE
| Crystal Structure of human RORgamma (C455E) LBD in complex with compound XY039 | 分子名称: | 2,4-difluoro-N-(1-((4-(trifluoromethyl)benzyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)benzenesulfonamide, ETHANOL, GLYCEROL, ... | 著者 | Wu, X, Li, C, Zhang, Y, Xu, Y. | 登録日 | 2022-05-07 | 公開日 | 2023-05-31 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as ROR gamma inverse agonists against prostate cancer. Acta Pharmacol.Sin., 2024
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5NUC
| STAPHYLOCOCCAL NUCLEASE, 1-N-PENTANE THIOL DISULFIDE TO V23C VARIANT | 分子名称: | CALCIUM ION, STAPHYLOCOCCAL NUCLEASE, THYMIDINE-3',5'-DIPHOSPHATE | 著者 | Wynn, R, Harkins, P.C, Richards, F.M, Fox, R.O. | 登録日 | 1998-01-11 | 公開日 | 1998-04-29 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Mobile unnatural amino acid side chains in the core of staphylococcal nuclease. Protein Sci., 5, 1996
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6W6D
| Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with SGC6870 inhibitor | 分子名称: | (5R)-4-(5-bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Halabelian, L, Zeng, H, Dong, A, Jin, J, Shen, Y, Kaniskan, H.U, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2020-03-16 | 公開日 | 2020-04-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J.Med.Chem., 64, 2021
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5NS3
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5NU3
| Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM-CBP | 分子名称: | (R,R)-2,3-BUTANEDIOL, CREB-binding protein, SULFATE ION, ... | 著者 | Huegle, M, Wohlwend, D. | 登録日 | 2017-04-28 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56, 2017
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1F8V
| THE STRUCTURE OF PARIACOTO VIRUS REVEALS A DODECAHEDRAL CAGE OF DUPLEX RNA | 分子名称: | CALCIUM ION, MATURE CAPSID PROTEIN BETA, MATURE CAPSID PROTEIN GAMMA, ... | 著者 | Tang, L, Johnson, K.N, Ball, L.A, Lin, T, Yeager, M, Johnson, J.E. | 登録日 | 2000-07-05 | 公開日 | 2000-12-06 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The structure of pariacoto virus reveals a dodecahedral cage of duplex RNA. Nat.Struct.Biol., 8, 2001
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8OID
| Cryo-EM structure of ADP-bound, filamentous beta-actin harboring the N111S mutation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Oosterheert, W, Blanc, F.E.C, Roy, A, Belyy, A, Hofnagel, O, Hummer, G, Bieling, P, Raunser, S. | 登録日 | 2023-03-22 | 公開日 | 2023-08-09 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments. Nat.Struct.Mol.Biol., 30, 2023
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5PZR
| Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[3-[3-[(3-chlorophenyl)sulfonylcarbamoylamino]propoxy]propyl]urea | 分子名称: | Fructose-1,6-bisphosphatase 1, N,N'-{oxybis[(propane-3,1-diyl)carbamoyl]}bis(3-chlorobenzene-1-sulfonamide) | 著者 | Ruf, A, Joseph, C, Alker, A, Banner, D, Tetaz, T, Benz, J, Kuhn, B, Rudolph, M.G, Yang, H, Shao, C, Burley, S.K. | 登録日 | 2017-04-11 | 公開日 | 2019-01-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the
allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[3-[3-[(3-chlorophenyl)sulfonylcarbamoylamino]propoxy]propyl]urea To be published
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5Q09
| Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-[4-bromo-6-(carbamoylamino)pyridin-2-yl]-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea | 分子名称: | Fructose-1,6-bisphosphatase 1, N-{[4-bromo-6-(carbamoylamino)pyridin-2-yl]carbamoyl}-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide | 著者 | Ruf, A, Joseph, C, Alker, A, Banner, D, Tetaz, T, Benz, J, Kuhn, B, Rudolph, M.G, Yang, H, Shao, C, Burley, S.K. | 登録日 | 2017-04-16 | 公開日 | 2019-01-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the
allosteric inhibitor 1-[4-bromo-6-(carbamoylamino)pyridin-2-yl]-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea To be published
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5NTU
| Crystal Structure of human Pro-myostatin Precursor at 2.6 A Resolution | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Growth/differentiation factor 8 | 著者 | Cotton, T.R, Fischer, G, Hyvonen, M. | 登録日 | 2017-04-28 | 公開日 | 2018-01-17 | 最終更新日 | 2018-02-21 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Structure of the human myostatin precursor and determinants of growth factor latency. EMBO J., 37, 2018
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8OLT
| Mitochondrial complex I from Mus musculus in the active state bound with piericidin A | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | 著者 | Grba, D.N, Chung, I, Bridges, H.R, Agip, A.N.A, Hirst, J. | 登録日 | 2023-03-30 | 公開日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I. Sci Adv, 9, 2023
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8OM1
| Mitochondrial complex I from Mus musculus in the active state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Grba, D.N, Chung, I, Bridges, H.R, Agip, A.N.A, Hirst, J. | 登録日 | 2023-03-31 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.39 Å) | 主引用文献 | Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I. Sci Adv, 9, 2023
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1GUZ
| Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases | 分子名称: | MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Dalhus, B, Sarinen, M, Sauer, U.H, Eklund, P, Johansson, K, Karlsson, A, Ramaswamy, S, Bjork, A, Synstad, B, Naterstad, K, Sirevag, R, Eklund, H. | 登録日 | 2002-02-04 | 公開日 | 2002-02-21 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases J.Mol.Biol., 318, 2002
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5YCA
| Crystal structure of inner membrane protein Bqt4 in complex with LEM2 | 分子名称: | Lap-Emerin-Man domain protein 2, Ubiquitin-like protein SMT3,Bouquet formation protein 4 | 著者 | Chen, Y, Hu, C. | 登録日 | 2017-09-07 | 公開日 | 2018-11-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast. Nucleic Acids Res., 47, 2019
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5PZS
| Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[6-[(3-chlorophenyl)sulfonylcarbamoylamino]hexyl]urea | 分子名称: | Fructose-1,6-bisphosphatase 1, N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) | 著者 | Ruf, A, Joseph, C, Alker, A, Banner, D, Tetaz, T, Benz, J, Kuhn, B, Rudolph, M.G, Yang, H, Shao, C, Burley, S.K. | 登録日 | 2017-04-11 | 公開日 | 2019-01-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.368 Å) | 主引用文献 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the
allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[6-[(3-chlorophenyl)sulfonylcarbamoylamino]hexyl]urea To be published
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5NWX
| Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6 | 分子名称: | Nuclear receptor coactivator 1, Signal transducer and activator of transcription 6 | 著者 | Russo, L, Giller, K, Pfitzner, E, Griesinger, C, Becker, S. | 登録日 | 2017-05-08 | 公開日 | 2017-12-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6. Sci Rep, 7, 2017
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5Q06
| Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(2-methyl-1,3-thiazol-4-yl)phenyl]sulfonylurea | 分子名称: | Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide | 著者 | Ruf, A, Joseph, C, Alker, A, Banner, D, Tetaz, T, Benz, J, Kuhn, B, Rudolph, M.G, Yang, H, Shao, C, Burley, S.K. | 登録日 | 2017-04-18 | 公開日 | 2019-01-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the
allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(2-methyl-1,3-thiazol-4-yl)phenyl]sulfonylurea To be published
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3UMX
| Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indol-3-yl)methylene]-7-(azepan-1-ylmethyl)-6-hydroxybenzofuran-3(2H)-one | 分子名称: | (2Z)-7-(azepan-1-ylmethyl)-6-hydroxy-2-(1H-indol-3-ylmethylidene)-1-benzofuran-3(2H)-one, Proto-oncogene serine/threonine-protein kinase pim-1, SULFATE ION | 著者 | Parker, L.J, Handa, N, Yokoyama, S. | 登録日 | 2011-11-15 | 公開日 | 2012-08-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor Acta Crystallogr.,Sect.F, 68, 2012
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5O55
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5NWM
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6W9H
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5O5A
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5NWN
| Deinococcus radiodurans BphP PAS-GAF-PHY Y263F mutant, dark | 分子名称: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome | 著者 | Takala, H, Westehoff, S, Ihalainen, J.A. | 登録日 | 2017-05-07 | 公開日 | 2018-04-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | On the (un)coupling of the chromophore, tongue interactions, and overall conformation in a bacterial phytochrome. J. Biol. Chem., 293, 2018
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5NXS
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5O97
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