3UMX

Crystal structure of Pim1 kinase in complex with inhibitor (Z)-2-[(1H-indol-3-yl)methylene]-7-(azepan-1-ylmethyl)-6-hydroxybenzofuran-3(2H)-one

Summary for 3UMX

• Entry DOI: 10.2210/pdb3umx/pdb
• Related: 3UIX 3UMW
• Descriptor: Proto-oncogene serine/threonine-protein kinase pim-1, (2Z)-7-(azepan-1-ylmethyl)-6-hydroxy-2-(1H-indol-3-ylmethylidene)-1-benzofuran-3(2H)-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: pim-1, kinase, p-loop, kinase inhibitor, rational drug design, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 1
• Total formula weight: 34672.25

Authors

Parker, L.J.,Handa, N.,Yokoyama, S. (deposition date: 2011-11-15, release date: 2012-08-08, Last modification date: 2023-11-01)

• Primary citation: Parker, L.J.,Watanabe, H.,Tsuganezawa, K.,Tomabechi, Y.,Handa, N.,Shirouzu, M.,Yuki, H.,Honma, T.,Ogawa, N.,Nagano, T.,Yokoyama, S.,Tanaka, A.; Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor; Acta Crystallogr.,Sect.F, 68:860-866, 2012; PubMed: 22869110; DOI: 10.1107/S1744309112027108

Experimental method

X-RAY DIFFRACTION (2.55 Å)