7C3I
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![BU of 7c3i by Molmil](/molmil-images/mine/7c3i) | Structure of L-lysine oxidase D212A/D315A | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Kitagawa, M, Matsumoto, Y, Inagaki, K, Imada, K. | 登録日 | 2020-05-12 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis of strict substrate recognition of l-lysine alpha-oxidase from Trichoderma viride. Protein Sci., 29, 2020
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6TKH
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![BU of 6tkh by Molmil](/molmil-images/mine/6tkh) | Tsetse thrombin inhibitor in complex with human alpha-thrombin - orthorhombic form at 7keV | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SODIUM ION, ... | 著者 | Calisto, B.M, Ripoll-Rozada, J, de Sanctis, D, Pereira, P.J.B. | 登録日 | 2019-11-28 | 公開日 | 2020-11-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates. Cell Chem Biol, 28, 2021
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5M0S
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![BU of 5m0s by Molmil](/molmil-images/mine/5m0s) | Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors | 分子名称: | CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, GLYCEROL, ... | 著者 | Keune, W.-J, Heidebrecht, T, Perrakis, A. | 登録日 | 2016-10-05 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators. J. Med. Chem., 60, 2017
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6TA0
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![BU of 6ta0 by Molmil](/molmil-images/mine/6ta0) | Human NAMPT in complex with nicotinic acid and phosphoribosyl pyrophosphate | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, GLYCEROL, NICOTINIC ACID, ... | 著者 | Houry, D, Raasakka, A, Kursula, P, Ziegler, M. | 登録日 | 2019-10-29 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Identification of structural determinants of NAMPT activity and substrate selectivity To Be Published
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5LRL
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![BU of 5lrl by Molmil](/molmil-images/mine/5lrl) | CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003492875 | 分子名称: | 2-azanyl-5-chloranyl-~{N}-[(9~{R})-4-(1~{H}-imidazo[4,5-c]pyridin-2-yl)-9~{H}-fluoren-9-yl]pyrimidine-4-carboxamide, Heat shock protein HSP 90-alpha | 著者 | Vallee, F, Dupuy, A. | 登録日 | 2016-08-19 | 公開日 | 2017-08-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Estimation of Protein-Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations. J.Chem.Inf.Model., 59, 2019
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7C67
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![BU of 7c67 by Molmil](/molmil-images/mine/7c67) | Crystal structure of beta-glycosides-binding protein of ABC transporter in a closed state bound to cellotriose | 分子名称: | 1,2-ETHANEDIOL, CARBONATE ION, CHLORIDE ION, ... | 著者 | Kanaujia, S.P, Chandravanshi, M, Samanta, R. | 登録日 | 2020-05-21 | 公開日 | 2020-10-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Conformational Trapping of a beta-Glucosides-Binding Protein Unveils the Selective Two-Step Ligand-Binding Mechanism of ABC Importers. J.Mol.Biol., 432, 2020
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6TL3
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![BU of 6tl3 by Molmil](/molmil-images/mine/6tl3) | Crystal structure of an Estrogen Receptor alpha 8-mer phosphopeptide in complex with 14-3-3sigma stabilized by a Pyrrolidone1 derivative | 分子名称: | 14-3-3 protein sigma, 5-[(2~{S},3~{R})-3-[(~{R})-azanyl(phenyl)methyl]-2-(4-nitrophenyl)-4,5-bis(oxidanylidene)pyrrolidin-1-yl]-2-oxidanyl-benzoic acid, Estrogen receptor | 著者 | Andrei, S.A, Bosica, F, Ottmann, C, O'Mahony, G. | 登録日 | 2019-11-30 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.455 Å) | 主引用文献 | Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization. Chemistry, 26, 2020
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5M17
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![BU of 5m17 by Molmil](/molmil-images/mine/5m17) | Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-1,2-dideoxymannose | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Glycosyl hydrolase family 71, ... | 著者 | Petricevic, M, Sobala, L.F, Fernandes, P.Z, Raich, L, Thompson, A.J, Bernardo-Seisdedos, G, Millet, O, Zhu, S, Sollogoub, M, Rovira, C, Jimenez-Barbero, J, Davies, G.J, Williams, S.J. | 登録日 | 2016-10-07 | 公開日 | 2017-01-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-alpha-1,2-Mannanase. J. Am. Chem. Soc., 139, 2017
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6TAB
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![BU of 6tab by Molmil](/molmil-images/mine/6tab) | Bd0314 DslA wild-type form 2 | 分子名称: | SLT domain-containing protein, SULFATE ION | 著者 | Lovering, A.L, Harding, C.J. | 登録日 | 2019-10-29 | 公開日 | 2020-07-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator Bdellovibrio bacteriovorus. Nat Commun, 11, 2020
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6TLB
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![BU of 6tlb by Molmil](/molmil-images/mine/6tlb) | Plasmodium falciparum lipocalin (PF3D7_0925900) | 分子名称: | GLYCEROL, SODIUM ION, Serine/threonine protein kinase | 著者 | Burda, P.C, Crosskey, T.D, Lauk, K, Wilmanns, M, Gilberger, T.W. | 登録日 | 2019-12-02 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | SOLUTION SCATTERING (2.85 Å), X-RAY DIFFRACTION | 主引用文献 | Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum. Cell Rep, 31, 2020
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5LRM
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![BU of 5lrm by Molmil](/molmil-images/mine/5lrm) | Structure of di-zinc MCR-1 in P41212 space group | 分子名称: | GLYCEROL, ZINC ION, phosphatidylethanolamine transferase Mcr-1 | 著者 | Hinchliffe, P, Spencer, J. | 登録日 | 2016-08-19 | 公開日 | 2016-12-07 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1. Sci Rep, 7, 2017
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6TLQ
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![BU of 6tlq by Molmil](/molmil-images/mine/6tlq) | ROR(gamma)t ligand binding domain in complex with cholesterol and allosteric ligand Glenmark | 分子名称: | 4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic acid, CHOLESTEROL, GLYCEROL, ... | 著者 | de Vries, R.M.J.M, Meijer, F.A, Brunsveld, L. | 登録日 | 2019-12-03 | 公開日 | 2020-12-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.761 Å) | 主引用文献 | Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t. Proc.Natl.Acad.Sci.USA, 118, 2021
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5LRT
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![BU of 5lrt by Molmil](/molmil-images/mine/5lrt) | Structure of the Deamidase-Depupylase Dop of the Prokaryotic Ubiquitin-like Modification Pathway in Complex with ADP and Phosphate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, Depupylase, ... | 著者 | Bolten, M, Vahlensieck, C, Lipp, C, Leibundgut, M, Ban, N, Weber-Ban, E. | 登録日 | 2016-08-19 | 公開日 | 2017-02-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Depupylase Dop Requires Inorganic Phosphate in the Active Site for Catalysis. J. Biol. Chem., 292, 2017
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7C6F
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![BU of 7c6f by Molmil](/molmil-images/mine/7c6f) | Crystal structure of beta-glycosides-binding protein (W177X) of ABC transporter in an open state | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | 著者 | Kanaujia, S.P, Chandravanshi, M, Samanta, R. | 登録日 | 2020-05-21 | 公開日 | 2020-09-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Conformational Trapping of a beta-Glucosides-Binding Protein Unveils the Selective Two-Step Ligand-Binding Mechanism of ABC Importers. J.Mol.Biol., 432, 2020
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6TAI
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![BU of 6tai by Molmil](/molmil-images/mine/6tai) | Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase with an empty active site at 1.55 Angstrom resolution | 分子名称: | ACETATE ION, GLYCEROL, Orotate phosphoribosyltransferase | 著者 | Navas-Yuste, S, Lopez-Estepa, M, Gomez, S, Fernandez, F.J, Vega, M.C. | 登録日 | 2019-10-29 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.551 Å) | 主引用文献 | Elucidating the Catalytic Reaction Mechanism of Orotate Phosphoribosyltransferase by Means of X-ray Crystallography and Computational Simulations Acs Catalysis, 10, 2020
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7C6M
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![BU of 7c6m by Molmil](/molmil-images/mine/7c6m) | Crystal structure of beta-glycosides-binding protein (W177X) of ABC transporter in a closed state bound to cellotetraose (Form I) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Kanaujia, S.P, Chandravanshi, M, Samanta, R. | 登録日 | 2020-05-21 | 公開日 | 2020-09-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Conformational Trapping of a beta-Glucosides-Binding Protein Unveils the Selective Two-Step Ligand-Binding Mechanism of ABC Importers. J.Mol.Biol., 432, 2020
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6TLY
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![BU of 6tly by Molmil](/molmil-images/mine/6tly) | Crystal structure of the unconventional kinetochore protein Bodo saltans KKT2 central domain | 分子名称: | CHLORIDE ION, Protein kinase, putative, ... | 著者 | Marciano, G, Nerusheva, O, Ishii, M, Akiyoshi, B. | 登録日 | 2019-12-03 | 公開日 | 2019-12-25 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Kinetoplastid kinetochore proteins KKT2 and KKT3 have unique centromere localization domains. J.Cell Biol., 220, 2021
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7C71
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![BU of 7c71 by Molmil](/molmil-images/mine/7c71) | Crystal structure of beta-glycosides-binding protein (E117A) of ABC transporter in an open state | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFITE ION, ... | 著者 | Kanaujia, S.P, Chandravanshi, M, Samanta, R. | 登録日 | 2020-05-22 | 公開日 | 2020-09-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Conformational Trapping of a beta-Glucosides-Binding Protein Unveils the Selective Two-Step Ligand-Binding Mechanism of ABC Importers. J.Mol.Biol., 432, 2020
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6TAO
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![BU of 6tao by Molmil](/molmil-images/mine/6tao) | The cytotoxin MakE from Vibrio cholerae | 分子名称: | NICKEL (II) ION, Non-hemolytic enterotoxin lytic component L1, SULFATE ION | 著者 | Persson, K, Nagampalli, R, Heidler, T, Wai, S.N. | 登録日 | 2019-10-30 | 公開日 | 2020-11-18 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion. Proc.Natl.Acad.Sci.USA, 118, 2021
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5M1K
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![BU of 5m1k by Molmil](/molmil-images/mine/5m1k) | Crystal structure of the large terminase nuclease from thermophilic phage G20c with bound Magnesium | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, Phage terminase large subunit, ... | 著者 | Xu, R.G, Jenkins, H.T, Chechik, M, Blagova, E.V, Greive, S.J, Antson, A.A. | 登録日 | 2016-10-09 | 公開日 | 2016-10-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Viral genome packaging terminase cleaves DNA using the canonical RuvC-like two-metal catalysis mechanism. Nucleic Acids Res., 45, 2017
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7C6Y
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![BU of 7c6y by Molmil](/molmil-images/mine/7c6y) | Crystal structure of beta-glycosides-binding protein (W41A) of ABC transporter in an open state (Form II) | 分子名称: | 1,2-ETHANEDIOL, CARBON DIOXIDE, CHLORIDE ION, ... | 著者 | Kanaujia, S.P, Chandravanshi, M, Samanta, R. | 登録日 | 2020-05-22 | 公開日 | 2020-09-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Conformational Trapping of a beta-Glucosides-Binding Protein Unveils the Selective Two-Step Ligand-Binding Mechanism of ABC Importers. J.Mol.Biol., 432, 2020
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5M1P
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![BU of 5m1p by Molmil](/molmil-images/mine/5m1p) | Crystal structure of the large terminase nuclease from thermophilic phage G20c with bound Calcium | 分子名称: | CALCIUM ION, Terminase large subunit | 著者 | Xu, R.G, Jenkins, H.T, Chechik, M, Blagova, E.V, Greive, S.J, Antson, A.A. | 登録日 | 2016-10-09 | 公開日 | 2016-10-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Viral genome packaging terminase cleaves DNA using the canonical RuvC-like two-metal catalysis mechanism. Nucleic Acids Res., 45, 2017
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7C87
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![BU of 7c87 by Molmil](/molmil-images/mine/7c87) | |
6TBD
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![BU of 6tbd by Molmil](/molmil-images/mine/6tbd) | |
6TBI
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![BU of 6tbi by Molmil](/molmil-images/mine/6tbi) | Structure of a beta galactosidase with inhibitor | 分子名称: | (1S,2S,3S,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol, ACETATE ION, Beta-galactosidase, ... | 著者 | Offen, W, Davies, G. | 登録日 | 2019-11-01 | 公開日 | 2020-08-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C -5a-Substituted Derivatives of 4- epi -Isofagomine. Molecules, 25, 2020
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