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6TLQ

ROR(gamma)t ligand binding domain in complex with cholesterol and allosteric ligand Glenmark

Summary for 6TLQ
Entry DOI10.2210/pdb6tlq/pdb
DescriptorNuclear receptor ROR-gamma, CHOLESTEROL, 4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic acid, ... (5 entities in total)
Functional Keywordsnuclear receptor, allosteric, inverse agonist, inhibitor, gene regulation
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight31608.39
Authors
de Vries, R.M.J.M.,Meijer, F.A.,Brunsveld, L. (deposition date: 2019-12-03, release date: 2020-12-16, Last modification date: 2024-01-24)
Primary citationde Vries, R.M.J.M.,Meijer, F.A.,Doveston, R.G.,Leijten-van de Gevel, I.A.,Brunsveld, L.
Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.
Proc.Natl.Acad.Sci.USA, 118:-, 2021
Cited by
PubMed: 33536342
DOI: 10.1073/pnas.2021287118
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.761 Å)
Structure validation

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