PDB: 230764 件ウェブページステータス検索Chemie searchBIRD

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4CWR	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 分子名称: 5-(1,3-benzodioxol-5-ylmethyl)-10-fluoro[1,2,4]triazolo[1,5-c]quinazolin-2-amine, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Casale, E, Amboldi, N, Brasca, G, Caronni, D, Colombo, N, Dalvit, C, Felder, E.R, Fogliatto, G, Isacchi, A, Mantegani, S, Polucci, P, Riceputi, L, Sola, F, Visco, C, Zuccotto, F, Casuscelli, F. 登録日 2014-04-03 公開日 2014-07-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors. Bioorg.Med.Chem., 22, 2014
4CWS	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 分子名称: 2-{[2-amino-5-(1,3-benzodioxol-5-ylmethyl)[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino}ethanol, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Casale, E, Amboldi, N, Brasca, G, Caronni, D, Colombo, N, Dalvit, C, Felder, E.R, Fogliatto, G, Isacchi, A, Mantegani, S, Polucci, P, Riceputi, L, Sola, F, Visco, C, Zuccotto, F, Casuscelli, F. 登録日 2014-04-03 公開日 2014-07-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors. Bioorg.Med.Chem., 22, 2014
9BKD	The structure of human Pdcd4 bound to the 40S small ribosomal subunit 分子名称: 18S rRNA, 40S ribosomal protein S12, 40S ribosomal protein S13, ... 著者 Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Albacete-Albacete, L, Ramakrishnan, V, S.Fraser, C. 登録日 2024-04-27 公開日 2024-09-04 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit. Nat Commun, 15, 2024
4V5B	Structure of PDF binding helix in complex with the ribosome. 分子名称: 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... 著者 Bingel-Erlenmeyer, R, Kohler, R, Kramer, G, Sandikci, A, Antolic, S, Maier, T, Schaffitzel, C, Wiedmann, B, Bukau, B, Ban, N. 登録日 2007-11-22 公開日 2014-07-09 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (3.74 Å) 主引用文献 A Peptide Deformylase-Ribosome Complex Reveals Mechanism of Nascent Chain Processing. Nature, 452, 2008
4CWF	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 分子名称: 5-propyl[1,2,4]triazolo[1,5-c]quinazolin-2-amine, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Casale, E, Amboldi, N, Brasca, G, Caronni, D, Colombo, N, Dalvit, C, Felder, E.R, Fogliatto, G, Isacchi, A, Mantegani, S, Polucci, P, Riceputi, L, Sola, F, Visco, C, Zuccotto, F, Casuscelli, F. 登録日 2014-04-02 公開日 2014-07-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors. Bioorg.Med.Chem., 22, 2014
4CWT	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 分子名称: 2-{[(2Z)-5-(1,3-benzodioxol-5-ylmethyl)-8-fluoro-2-imino-2,3-dihydro[1,2,4]triazolo[1,5-c]quinazolin-10-yl]amino}ethanol, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Casale, E, Amboldi, N, Brasca, G, Caronni, D, Colombo, N, Dalvit, C, Felder, E.R, Fogliatto, G, Isacchi, A, Mantegani, S, Polucci, P, Riceputi, L, Sola, F, Visco, C, Zuccotto, F, Casuscelli, F. 登録日 2014-04-03 公開日 2014-07-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors. Bioorg.Med.Chem., 22, 2014
8RO1	Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'') 分子名称: CWF19-like protein 1 homolog, CWF19-like protein 2 homolog, Cell division cycle 5-like protein, ... 著者 Vorlaender, M.K, Rothe, P, Plaschka, C. 登録日 2024-01-11 公開日 2024-08-07 最終更新日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Mechanism for the initiation of spliceosome disassembly. Nature, 632, 2024
4CWQ	Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 分子名称: 2-amino-5-(1,3-benzodioxol-5-ylmethyl)[1,2,4]triazolo[1,5-c]quinazoline-8-sulfonamide, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Casale, E, Amboldi, N, Brasca, G, Caronni, D, Colombo, N, Dalvit, C, Felder, E.R, Fogliatto, G, Isacchi, A, Mantegani, S, Polucci, P, Riceputi, L, Sola, F, Visco, C, Zuccotto, F, Casuscelli, F. 登録日 2014-04-03 公開日 2014-07-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors. Bioorg.Med.Chem., 22, 2014
1TNP	STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH 分子名称: TROPONIN-C (APO) 著者 Gagne, S.M, Sykes, B.D. 登録日 1995-07-07 公開日 1995-10-15 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structures of the troponin C regulatory domains in the apo and calcium-saturated states. Nat.Struct.Biol., 2, 1995
5CZB	HCV NS5B IN COMPLEX WITH LIGAND IDX17119-5 分子名称: 1-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-3-{[(R)-(2,4-dimethylphenyl)(methoxy)phosphoryl]amino}-1H-pyrazole-4-carboxylic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... 著者 Pierra, C, Dousson, C, Augustin, M. 登録日 2015-07-31 公開日 2016-06-15 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase. Bioorg.Med.Chem.Lett., 26, 2016
7QPB	Catalytic C-lobe of the HECT-type ubiquitin ligase E6AP in complex with a hybrid foldamer-peptide macrocycle 分子名称: Isoform I of Ubiquitin-protein ligase E3A, hybrid foldamer-peptide macrocycle 著者 Dengler, S, Howard, R.T, Morozov, V, Tsiamantas, C, Douat, C, Suga, H, Huc, I. 登録日 2022-01-03 公開日 2023-09-27 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.342 Å) 主引用文献 Display Selection of a Hybrid Foldamer-Peptide Macrocycle. Angew.Chem.Int.Ed.Engl., 62, 2023
4UWU	Lysozyme soaked with a ruthenium based CORM with a pyridine ligand (complex 7) 分子名称: CARBON MONOXIDE, CHLORIDE ION, FORMIC ACID, ... 著者 Santos, M.F.A, Mukhopadhyay, A, Romao, M.J, Romao, C.C, Santos-Silva, T. 登録日 2014-08-14 公開日 2014-12-10 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 A Contribution to the Rational Design of Ru(Co)3Cl2L Complexes for in Vivo Delivery of Co. Dalton Trans, 44, 2015
1U97	Solution Structure of Apo Yeast Cox17 分子名称: Cytochrome c oxidase copper chaperone 著者 Abajian, C, Yatsunyk, L.A, Ramirez, B.E, Rosenzweig, A.C. 登録日 2004-08-09 公開日 2004-10-05 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Yeast cox17 solution structure and Copper(I) binding. J.Biol.Chem., 279, 2004
5CXH	SYK catalytic domain complexed with a potent orally bioavailable thiazole inhibitor 分子名称: (4R)-4-[(1R)-1-{[6-(3,4-dimethoxyphenyl)[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy}ethyl]pyrrolidin-2-one, Tyrosine-protein kinase SYK 著者 Lee, C.C. 登録日 2015-07-29 公開日 2015-09-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg.Med.Chem.Lett., 25, 2015
1U7L	Crystal Structure of subunit C (vma5p) of the yeast V-ATPase 分子名称: L(+)-TARTARIC ACID, Vacuolar ATP synthase subunit C 著者 Nelson, N, Frolow, F, Drory, O. 登録日 2004-08-04 公開日 2004-11-23 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structure of yeast V-ATPase subunit C reveals its stator function Embo Rep., 5, 2004
4V3R	Designed armadillo repeat protein with 5 internal repeats, 2nd generation C-cap and 3rd generation N-cap. 分子名称: MAGNESIUM ION, YIII_M5_AII 著者 Reichen, C, Madhurantakam, C, Pluckthun, A, Mittl, P. 登録日 2014-10-20 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects Acta Crystallogr.,Sect.D, 72, 2016
1L6T	STRUCTURE OF ALA24/ASP61 TO ASP24/ASN61 SUBSTITUTED SUBUNIT C OF ESCHERICHIA COLI ATP SYNTHASE 分子名称: ATP SYNTHASE C CHAIN 著者 Dmitriev, O.Y, Abildgaard, F, Markley, J.L, Fillingame, R.H. 登録日 2002-03-13 公開日 2002-07-24 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure of Ala24/Asp61 --> Asp24/Asn61 substituted subunit c of Escherichia coli ATP synthase: implications for the mechanism of proton transport and rotary movement in the F0 complex. Biochemistry, 41, 2002
2V0N	ACTIVATED RESPONSE REGULATOR PLED IN COMPLEX WITH C-DIGMP AND GTP- ALPHA-S 分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), BERYLLIUM TRIFLUORIDE ION, CHLORIDE ION, ... 著者 Wassmann, P, Schirmer, T. 登録日 2007-05-15 公開日 2007-08-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Structure of Bef3--Modified Response Regulator Pled: Implications for Diguanylate Cyclase Activation, Catalysis, and Feedback Inhibition Structure, 15, 2007
3S67	Crystal structure of V57P mutant of human cystatin C 分子名称: ACETATE ION, CHLORIDE ION, Cystatin-C, ... 著者 Orlikowska, M, Szymanska, A, Borek, D, Otwinowski, Z, Skowron, P, Jankowska, E. 登録日 2011-05-25 公開日 2012-05-30 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein. Acta Crystallogr.,Sect.D, 69, 2013
8RO0	Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS') 分子名称: Cell division cycle 5-like protein, Coiled-coil domain-containing protein 12, GCF C-terminal domain-containing protein, ... 著者 Vorlaender, M.K, Rothe, P, Plaschka, C. 登録日 2024-01-11 公開日 2024-08-07 最終更新日 2024-11-20 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Mechanism for the initiation of spliceosome disassembly. Nature, 632, 2024
9BLN	The structure of human Pdcd4 bound to the 40S-eIF4A-eIF3-eIF1 complex 分子名称: 40S ribosomal protein S14, ACETIC ACID, Eukaryotic initiation factor 4A-I, ... 著者 Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Yifei, D, Albacete-Albacete, L, Ramakrishnan, V, S Fraser, C. 登録日 2024-04-30 公開日 2024-09-04 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit. Nat Commun, 15, 2024
3SJH	Crystal Structure of a chimera containing the N-terminal domain (residues 8-29) of drosophila Ciboulot and the C-terminal domain (residues 18-44) of bovine Thymosin-beta4, bound to G-actin-ATP-Latrunculin A 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... 著者 Renault, L, Husson, C, Carlier, M.F, Didry, D. 登録日 2011-06-21 公開日 2012-01-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 How a single residue in individual beta-thymosin/WH2 domains controls their functions in actin assembly Embo J., 31, 2012
4DAI	Crystal structure of B. anthracis DHPS with compound 23 分子名称: (7-amino-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)acetic acid, Dihydropteroate Synthase, SULFATE ION 著者 Hammoudeh, D, Lee, R.E, White, S.W. 登録日 2012-01-12 公開日 2012-03-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity. Chemmedchem, 7, 2012
1TRF	SOLUTION STRUCTURE OF THE TR1C FRAGMENT OF SKELETAL MUSCLE TROPONIN-C 分子名称: TROPONIN C 著者 Findlay, W.A, Soennichsen, F.D, Sykes, B.D. 登録日 1993-12-29 公開日 1994-10-15 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structure of the TR1C fragment of skeletal muscle troponin-C. J.Biol.Chem., 269, 1994
4UYP	High resolution structure of the third cohesin ScaC in complex with the ScaB dockerin with a mutation in the N-terminal helix (IN to SI) from Acetivibrio cellulolyticus displaying a type I interaction. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... 著者 Cameron, K, Alves, V.D, Bule, P, Ferreira, L.M.A, Fontes, C.M.G.A, Najmudin, S. 登録日 2014-09-02 公開日 2015-04-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Cell-surface Attachment of Bacterial Multienzyme Complexes Involves Highly Dynamic Protein-Protein Anchors. J. Biol. Chem., 290, 2015

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