4AT4
 
 | | CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH EX429 | | 分子名称: | 1-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea, BDNF/NT-3 GROWTH FACTORS RECEPTOR | | 著者 | Bertrand, T, Kothe, M, Liu, J, Dupuy, A, Rak, A, Berne, P.F, Davis, S, Gladysheva, T, Valtre, C, Crenne, J.Y, Mathieu, M. | | 登録日 | 2012-05-03 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | The Crystal Structures of Trka and Trkb Suggest Key Regions for Achieving Selective Inhibition.
J.Mol.Biol., 423, 2012
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4AZF
 | | Human DYRK2 in complex with Leucettine L41 | | 分子名称: | 1,2-ETHANEDIOL, 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, DYRK2 DUAL-SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASE 2, ... | | 著者 | Elkins, J.M, Soundararajan, M, Muniz, J.R.C, Tahtouh, T, Burgy, G, Durieu, E, Lozach, O, Cochet, C, Schmid, R.S, Lo, D.C, Delhommel, F, Carreaux, F, Bazureau, J.P, Meijer, L, Edwards, A, Bountra, C, Knapp, S. | | 登録日 | 2012-06-25 | | 公開日 | 2012-09-05 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.
J.Med.Chem., 55, 2012
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3H5K
 | | Crystal structure of the ribosome inactivating protein PDL1 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Ribosome-inactivating protein PD-L1/PD-L2 | | 著者 | Ruggiero, A, Di Maro, A, Severino, V, Chambery, A, Berisio, R. | | 登録日 | 2009-04-22 | | 公開日 | 2009-10-13 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. Leaves with the property to induce DNA cleavage
Biopolymers, 91, 2009
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9ED4
 | | A composite map of mTORC1-Rag-Ragultor-4EBP1 on membrane | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, GTP-binding protein Rheb, ... | | 著者 | Cui, Z, Hurley, J. | | 登録日 | 2024-11-15 | | 公開日 | 2025-09-10 | | 最終更新日 | 2025-10-01 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Structural basis for mTORC1 activation on the lysosomal membrane.
Nature, 2025
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4N4T
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4HUT
 | | Structure of ATP:co(I)rrinoid adenosyltransferase (CobA) from Salmonella enterica in complex with four and five-coordinate cob(II)alamin and ATP | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, COBALAMIN, ... | | 著者 | Moore, T.C, Newmister, S.A, Rayment, I, Escalante-Semerena, J.C. | | 登録日 | 2012-11-04 | | 公開日 | 2013-01-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural Insights into the Mechanism of Four-Coordinate Cob(II)alamin Formation in the Active Site of the Salmonella enterica ATP:Co(I)rrinoid Adenosyltransferase Enzyme: Critical Role of Residues Phe91 and Trp93.
Biochemistry, 51, 2012
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4N6Y
 | | Pim1 Complexed with a phenylcarboxamide | | 分子名称: | 2-(acetylamino)-N-[2-(piperidin-1-yl)phenyl]-1,3-thiazole-4-carboxamide, Serine/threonine-protein kinase pim-1 | | 著者 | Bellamacina, C.R, Le, V, Shu, W, Burger, M.T, Bussiere, D. | | 登録日 | 2013-10-14 | | 公開日 | 2013-11-06 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
ACS Med Chem Lett, 4, 2013
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6BV9
 | | Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana after overnight soak with juglone | | 分子名称: | 5-hydroxynaphthalene-1,4-dione, CHLORIDE ION, Proteinaceous RNase P 1, ... | | 著者 | Karasik, A, Wu, N, Fierke, C.A, Koutmos, M. | | 登録日 | 2017-12-12 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Inhibition of protein-only RNase P with Gambogic acid and Juglone
To Be Published
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8OXD
 | | Structure of the human LYVE-1 (lymphatic vessel endothelial receptor-1) hyaluronan binding domain bound with decasaccharide hyaluronan. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, Lymphatic vessel endothelial hyaluronic acid receptor 1 | | 著者 | Ni, T, Banerji, N, Jackson, D.J, Gilbert, R.J.C. | | 登録日 | 2023-05-01 | | 公開日 | 2024-11-13 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Structure of the murine LYVE-1 (lymphatic vessel endothelial receptor-1) hyaluronan binding domain in an unliganded state
Nature Communications, 2025
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9N3N
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9N3O
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6BZ3
 | | Complex structure of FAK FAT domain and DCC P3 motif | | 分子名称: | CALCIUM ION, Focal adhesion kinase 1, Netrin receptor DCC | | 著者 | Xu, S, Wang, J.-H. | | 登録日 | 2017-12-22 | | 公開日 | 2018-04-04 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | | 主引用文献 | The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction.
Cell Discov, 4, 2018
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1KYX
 | | Lumazine Synthase from S.pombe bound to carboxyethyllumazine | | 分子名称: | 3-[8-((2S,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL)-2,4,7-TRIOXO-1,3,8-TRIHYDROPTERIDIN-6-YL]PROPANOIC ACID, 6,7-Dimethyl-8-ribityllumazine Synthase, PHOSPHATE ION | | 著者 | Gerhardt, S, Haase, I, Steinbacher, S, Kaiser, J.T, Cushman, M, Bacher, A, Huber, R, Fischer, M. | | 登録日 | 2002-02-06 | | 公開日 | 2002-07-24 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase.
J.Mol.Biol., 318, 2002
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4ZSA
 | | Crystal structure of FGFR1 kinase domain in complex with 7n | | 分子名称: | 4-(4-ethylpiperazin-1-yl)-N-[6-(3-methoxyphenyl)-2H-indazol-3-yl]benzamide, Fibroblast growth factor receptor 1 | | 著者 | Liu, Q.F, Xu, Y.C. | | 登録日 | 2015-05-13 | | 公開日 | 2015-06-17 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold.
Org.Biomol.Chem., 13, 2015
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5G4S
 | | BROMODOMAIN OF HUMAN BRPF1 WITH N-1,3-dimethyl-6-2R-2- methylpiperazin-1-yl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl-N- ethyl-2-methoxybenzamide | | 分子名称: | 1,2-ETHANEDIOL, N-[1,3-dimethyl-6-[(2R)-2-methylpiperazin-1-yl]-2-oxidanylidene-benzimidazol-5-yl]-N-ethyl-2-methoxy-benzamide, PEREGRIN | | 著者 | Chung, C. | | 登録日 | 2016-05-16 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Gsk6853, a Chemical Probe for Inhibition of the Brpf1 Bromodomain.
Acs Med.Chem.Lett., 7, 2016
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3BMX
 | | Beta-N-hexosaminidase (YbbD) from Bacillus subtilis | | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ACETATE ION, SODIUM ION, ... | | 著者 | Fischer, S. | | 登録日 | 2007-12-13 | | 公開日 | 2008-12-16 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural and kinetic analysis of Bacillus subtilis N-acetylglucosaminidase reveals a unique Asp-His dyad mechanism
J.Biol.Chem., 285, 2010
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7V0T
 | | Local refinement of Band 3-I cytoplasmic domains, class 1 of erythrocyte ankyrin-1 complex | | 分子名称: | Band 3 anion transport protein | | 著者 | Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B. | | 登録日 | 2022-05-11 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022
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4NP1
 | | NITROPHORIN 1 COMPLEX WITH NITRIC OXIDE | | 分子名称: | NITRIC OXIDE, NITROPHORIN 1, PHOSPHATE ION, ... | | 著者 | Weichsel, A, Andersen, J.F, Walker, F.A, Montfort, W.R. | | 登録日 | 1998-06-26 | | 公開日 | 1998-11-11 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Nitric Oxide Binding to the Ferri-and Ferroheme States of Nitrophorin 1, a Reversible No-Binding Heme Protein from the Saliva of the Blood-Sucking Insect, Rhodnius Prolixus
To be Published
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7V0Y
 | | Local refinement of Band 3-III cytoplasmic domains, class 1 of erythrocyte ankyrin-1 complex | | 分子名称: | Band 3 anion transport protein | | 著者 | Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B. | | 登録日 | 2022-05-11 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022
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1OM0
 | | crystal structure of xylanase inhibitor protein (XIP-I) from wheat | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Xylanase Inhibitor Protein I | | 著者 | Payan, F, Flatman, R, Porciero, S, Williamson, G, Juge, N, Roussel, A. | | 登録日 | 2003-02-24 | | 公開日 | 2003-06-03 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural analysis of xylanase inhibitor protein I (XIP-I), a proteinaceous xylanase inhibitor from wheat (Triticum aestivum, var. Soisson).
Biochem.J., 372, 2003
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8UWA
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7V0U
 | | Local refinement of Band 3-II cytoplasmic domains, class 1 of erythrocyte ankyrin-1 complex | | 分子名称: | Band 3 anion transport protein | | 著者 | Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B. | | 登録日 | 2022-05-11 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022
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6SHJ
 | | Escherichia coli AGPase in complex with FBP. Symmetry applied C2 | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, Glucose-1-phosphate adenylyltransferase | | 著者 | Cifuente, J.O, Comino, N, D'Angelo, C, Marina, A, Gil-Carton, D, Albesa-Jove, D, Guerin, M.E. | | 登録日 | 2019-08-07 | | 公開日 | 2020-02-05 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM.
Curr Res Struct Biol, 2, 2020
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5VE7
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2IU8
 | | Chlamydia trachomatis LpxD with 25mM UDPGlcNAc (Complex I) | | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, PALMITIC ACID, ... | | 著者 | Buetow, L, Smith, T.K, Dawson, A, Fyffe, S, Hunter, W.N. | | 登録日 | 2006-05-30 | | 公開日 | 2007-02-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure and Reactivity of Lpxd, the N-Acyltransferase of Lipid a Biosynthesis
Proc.Natl.Acad.Sci.USA, 104, 2007
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