4N4T
Co-crystal structure of tankyrase 1 with compound 3 [(4S)-3-{4-[6-amino-5-(pyrimidin-2-yl)pyridin-3-yl]phenyl}-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one]
Summary for 4N4T
Entry DOI | 10.2210/pdb4n4t/pdb |
Related | 4K4F 4N3R 4N4V |
Descriptor | Tankyrase-1, ZINC ION, (4S)-3-{4-[6-amino-5-(pyrimidin-2-yl)pyridin-3-yl]phenyl}-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one, ... (4 entities in total) |
Functional Keywords | tankyrase, parp, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (mouse) |
Cellular location | Cytoplasm (By similarity): Q6PFX9 |
Total number of polymer chains | 2 |
Total formula weight | 51088.47 |
Authors | Huang, X. (deposition date: 2013-10-08, release date: 2013-12-11, Last modification date: 2024-02-28) |
Primary citation | Huang, H.,Guzman-Perez, A.,Acquaviva, L.,Berry, V.,Bregman, H.,Dovey, J.,Gunaydin, H.,Huang, X.,Huang, L.,Saffran, D.,Serafino, R.,Schneider, S.,Wilson, C.,DiMauro, E.F. Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors. ACS Med Chem Lett, 4:1218-1223, 2013 Cited by PubMed: 24900633DOI: 10.1021/ml4003315 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.315 Å) |
Structure validation
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