8OXD

Structure of the human LYVE-1 (lymphatic vessel endothelial receptor-1) hyaluronan binding domain bound with decasaccharide hyaluronan.

Summary for 8OXD

• Entry DOI: 10.2210/pdb8oxd/pdb
• Descriptor: Lymphatic vessel endothelial hyaluronic acid receptor 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: hyaluronan binding, cell migration, lymphatic system, cell adhesion
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 17922.30

Authors

Ni, T.,Banerji, N.,Jackson, D.J.,Gilbert, R.J.C. (deposition date: 2023-05-01, release date: 2024-11-13, Last modification date: 2025-03-26)

• Primary citation: Bano, F.,Banerji, S.,Ni, T.,Green, D.E.,DeAngelis, P.L.,Paci, E.,Lepsik, M.,Jackson, D.J.,Gilbert, R.J.C.; Structure of the murine LYVE-1 (lymphatic vessel endothelial receptor-1) hyaluronan binding domain in an unliganded state; Nature Communications, 2025

Experimental method

X-RAY DIFFRACTION (1.32 Å)