PDB: 46188 件ウェブページステータス検索Chemie searchBIRD

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4QP1	Crystal structure of ERK2 in complex with N-cyclohexyl-9H-purin-6-amine 分子名称: IMIDAZOLE, Mitogen-activated protein kinase 1, N-BENZYL-9H-PURIN-6-AMINE 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2015-12-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4PX9	DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X 著者 Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. 登録日 2014-03-22 公開日 2015-03-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis. J.Mol.Biol., 427, 2015
4QP9	Crystal Structure of ERK2 in complex with 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine 分子名称: 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
7P0B	Human mitochondrial Lon protease without substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Valentin Gese, G, Shahzad, S, Hallberg, B.M. 登録日 2021-06-29 公開日 2021-08-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.11 Å) 主引用文献 A dual allosteric pathway drives human mitochondrial Lon To Be Published
7P0M	Human mitochondrial Lon protease with substrate in the ATPase and protease domains 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Valentin Gese, G, Shahzad, S, Hallberg, B.M. 登録日 2021-06-30 公開日 2021-08-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.75 Å) 主引用文献 A dual allosteric pathway drives human mitochondrial Lon To Be Published
7P09	Human mitochondrial Lon protease with substrate in the ATPase domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Valentin Gese, G, Shahzad, S, Hallberg, B.M. 登録日 2021-06-29 公開日 2021-08-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 A dual allosteric pathway drives human mitochondrial Lon To Be Published
4Q0V	Crystal structure of Acinetobacter sp. DL28 L-ribose isomerase mutant E204Q in complex with L-ribulose 分子名称: COBALT (II) ION, COBALT HEXAMMINE(III), L-Ribose isomerase, ... 著者 Yoshida, H, Yoshihara, A, Teraoka, M, Izumori, K, Kamitori, S. 登録日 2014-04-02 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 X-ray structure of a novel L-ribose isomerase acting on a non-natural sugar L-ribose as its ideal substrate. Febs J., 281, 2014
4IA2	Diastereotopic and Deuterium Effects in Gemini 分子名称: 21-NOR-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, 20-(4-HYDROXY-4-METHYLPENTYL)-, (1A,3B,5Z,7E), ... 著者 Maehr, H, Rochel, N, Suh, N, Uskokovic, M. 登録日 2012-12-06 公開日 2013-04-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Diastereotopic and deuterium effects in gemini. J.Med.Chem., 56, 2013
2NN6	Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40 分子名称: 3'-5' exoribonuclease CSL4 homolog, Exosome complex exonuclease RRP4, Exosome complex exonuclease RRP40, ... 著者 Lima, C.D. 登録日 2006-10-23 公開日 2006-12-26 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell(Cambridge,Mass.), 127, 2006
4MR1	X-ray structure of the adduct between hen egg white lysozyme and cis-diamminediiodoplatinum(II) 分子名称: CHLORIDE ION, Lysozyme C, SODIUM ION, ... 著者 Merlino, A. 登録日 2013-09-17 公開日 2014-06-04 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Peculiar features in the crystal structure of the adduct formed between cis-PtI2(NH3)2 and hen egg white lysozyme. Inorg.Chem., 52, 2013
3KDF	X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression 分子名称: 1,2-ETHANEDIOL, Replication protein A 14 kDa subunit, Replication protein A 32 kDa subunit 著者 Burgie, E.S, Bingman, C.A, Phillips Jr, G.N, Fox, B.G, Makino, S.-I, Center for Eukaryotic Structural Genomics (CESG) 登録日 2009-10-22 公開日 2009-12-01 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (1.975 Å) 主引用文献 X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression To be Published
6Z6F	HDAC-PC 分子名称: HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... 著者 Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. 登録日 2020-05-28 公開日 2021-02-17 実験手法 ELECTRON MICROSCOPY (3.11 Å) 主引用文献 Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
6Z6H	HDAC-DC 分子名称: HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... 著者 Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. 登録日 2020-05-28 公開日 2021-02-17 実験手法 ELECTRON MICROSCOPY (8.55 Å) 主引用文献 Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
6Z6O	HDAC-TC 分子名称: HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... 著者 Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. 登録日 2020-05-28 公開日 2021-02-17 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
3F2A	Crystal structure of human Pim-1 in complex with DAPPA 分子名称: (2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid, MAGNESIUM ION, Proto-oncogene serine/threonine-protein kinase Pim-1 著者 Qian, K. 登録日 2008-10-29 公開日 2009-03-10 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. J.Med.Chem., 52, 2009
3KLW	Crystal structure of primosomal replication protein n from Bordetella pertussis. northeast structural genomics consortium target ber132. 分子名称: Primosomal replication protein n 著者 Kuzin, A.P, Neely, H, Vorobiev, S.M, Seetharaman, J, Forouhar, F, Wang, H, Janjua, H, Maglaqui, M, Xiao, T, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) 登録日 2009-11-09 公開日 2009-11-24 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of primosomal replication protein n from Bordetella pertussis. northeast structural genomics consortium target ber132. To be Published
6EM5	State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes 分子名称: 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 25S ribosomal RNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... 著者 Kater, L, Cheng, J, Barrio-Garcia, C, Hurt, E, Beckmann, R. 登録日 2017-10-01 公開日 2017-12-27 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes. Cell, 171, 2017
3JUZ	Crystal structure of a mutant of RelB dimerization domain(M5) 分子名称: Transcription factor RelB 著者 Vu, D, Huang, D.B, Ghosh, G. 登録日 2009-09-15 公開日 2010-11-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Instability of the RelB dimerization domain is functionally important To be Published
7OXO	human LonP1, R-state, incubated in AMPPCP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Abrahams, J.P, Mohammed, I, Schmitz, K.A, Schenck, N, Maier, T. 登録日 2021-06-22 公開日 2021-12-22 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Catalytic cycling of human mitochondrial Lon protease. Structure, 30, 2022
2NRR	Crystal structure of the C-terminal RNAseH endonuclase domain of UvrC 分子名称: UvrABC system protein C 著者 Karakas, E, Truglio, J.J, Kisker, C. 登録日 2006-11-02 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Embo J., 26, 2007
2ICT	Crystal structure of the bacterial antitoxin HigA from Escherichia coli at pH 8.5. Northeast Structural Genomics TARGET ER390. 分子名称: antitoxin higa 著者 Arbing, M.A, Abashidze, M, Hurley, J.M, Zhao, L, Janjua, H, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Inouye, M, Woychik, N.A, Montelione, G.T, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) 登録日 2006-09-13 公開日 2006-09-26 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Crystal Structures of Phd-Doc, HigA, and YeeU Establish Multiple Evolutionary Links between Microbial Growth-Regulating Toxin-Antitoxin Systems. Structure, 18, 2010
3JBP	Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to E-tRNA 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ... 著者 Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J. 登録日 2015-09-16 公開日 2015-10-14 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (6.7 Å) 主引用文献 Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Res., 43, 2015
4L8R	Structure of mrna stem-loop, human stem-loop binding protein and 3'hexo ternary complex 分子名称: 3'-5' exoribonuclease 1, HISTONE MRNA STEM-LOOP, Histone RNA hairpin-binding protein 著者 Tan, D, Tong, L. 登録日 2013-06-17 公開日 2013-07-10 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of Histone Mrna Stem-Loop, Human Stem-Loop Binding Protein, and 3'Hexo Ternary Complex. Science, 339, 2013
3JY0	Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors 分子名称: 8-chloro-2-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}[1]benzothieno[3,2-d]pyrimidin-4(3H)-one, Proto-oncogene serine/threonine-protein kinase Pim-1 著者 Stoll, V.S. 登録日 2009-09-21 公開日 2009-11-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors To be Published
3DIK	Pseudo-atomic model of the HIV-1 CA hexameric lattice 分子名称: Capsid protein p24 著者 Ganser-Pornillos, B.K, Cheng, A, Yeager, M. 登録日 2008-06-20 公開日 2008-09-16 最終更新日 2024-02-21 実験手法 ELECTRON CRYSTALLOGRAPHY (9 Å) 主引用文献 Structure of full-length HIV-1 CA: a model for the mature capsid lattice Cell(Cambridge,Mass.), 131, 2007

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