PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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4ALV	Benzofuropyrimidinone Inhibitors of Pim-1 分子名称: 8-bromo-2-{2-chloro-4-[(piperidin-4-ylmethyl)amino]phenyl}[1]benzofuro[3,2-d]pyrimidin-4(3H)-one, IMIDAZOLE, SERINE/THREONINE-PROTEIN KINASE PIM-1 著者 Stout, T.J, Adams, L. 登録日 2012-03-05 公開日 2013-01-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 The Design, Synthesis, and Biological Evaluation of Pim Kinase Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
6KPB	The crystal structure of the JACKDAW/IDD10 bound to the homodimeric SCL3 分子名称: DI(HYDROXYETHYL)ETHER, Peptide from Zinc finger protein JACKDAW, Scarecrow-like protein 3 著者 Hirano, Y, Hakoshima, T. 登録日 2019-08-15 公開日 2020-09-02 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of the SCL3 homodimer bound to the BIRD/IDD transcription factor To Be Published
4XT9	RORgamma (263-509) complexed with GSK2435341A and SRC2 分子名称: LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, N-[4-(2,5-dichlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, ... 著者 Wang, Y, Ma, Y. 登録日 2015-01-23 公開日 2015-08-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists Bioorg.Med.Chem., 23, 2015
4XUH	PPARgamma ligand binding domain in complex with sulindac sulfide 分子名称: 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]ethanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Puhl, A.C, Polikaporv, I, Webb, P. 登録日 2015-01-25 公開日 2016-07-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs. Nucl Recept Signal, 13, 2015
7AXB	Crystal structure of the hPXR-LBD in complex with endosulfan 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, Nuclear receptor subfamily 1 group I member 2, ... 著者 Huet, T, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AXG	Crystal structure of the hPXR-LBD in complex with tributyltin 分子名称: Nuclear receptor subfamily 1 group I member 2, tributylstannanyl 著者 Delfosse, V, Huet, T, Blanc, P, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AHJ	Crystal structure of PPARgamma V290M mutant ligand binding domain in complex with farglitazar 分子名称: 2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID, Peroxisome proliferator-activated receptor gamma 著者 Schoenmakers, E, Schwabe, B.T.W, Fairall, L, Chatterjee, K, Schwabe, J.W.R. 登録日 2020-09-24 公開日 2020-10-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of PPARgamma V290M mutant ligand binding domain in complex with farglitazar To Be Published
7AX9	Crystal structure of the hPXR-LBD in complex with cis-chlordane 分子名称: (+)cis-chlordane, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Granell, M, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AXH	Crystal structure of the hPXR-LBD in complex with alpha-zearalanol 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ISOPROPYL ALCOHOL, Nuclear receptor subfamily 1 group I member 2, ... 著者 Huet, T, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
4XUM	PPARgamma ligand binding domain in complex with indomethacin 分子名称: INDOMETHACIN, Peroxisome proliferator-activated receptor gamma 著者 Puhl, A.C, Webb, P, Polikarpov, I. 登録日 2015-01-26 公開日 2015-11-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs. Nucl Recept Signal, 13, 2015
6L16	Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives 分子名称: 2-[4-[2-(7-chloranylpyrido[3,4-b][1,4]benzoxazin-5-yl)ethyl]piperidin-1-yl]ethanamine, Serine/threonine-protein kinase pim-1 著者 Zhang, W, Xie, Y, Cao, R, Huang, N, Zhou, Y. 登録日 2019-09-27 公開日 2020-05-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
7AXD	Crystal structure of the hPXR-LBD in complex with fipronil 分子名称: ISOPROPYL ALCOHOL, Nuclear receptor subfamily 1 group I member 2, fipronil 著者 Granell, M, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AXL	Crystal structure of the hPXR-LBD in complex with estradiol and heptachlor endo-epoxide 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ESTRADIOL, Nuclear receptor subfamily 1 group I member 2, ... 著者 Delfosse, V, Granell, M, Blanc, P, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AX8	Crystal structure of the hPXR-LBD in apo form (P43212 SG) 分子名称: 1,2-ETHANEDIOL, Nuclear receptor subfamily 1 group I member 2 著者 Delfosse, V, Huet, T, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AXE	Crystal structure of the hPXR-LBD in complex with oxadiazon 分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Nuclear receptor subfamily 1 group I member 2, ... 著者 Harrus, D, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AXK	Crystal structure of the hPXR-LBD in complex with estradiol and endosulfan 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ESTRADIOL, GLYCEROL, ... 著者 Huet, T, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
1YTA	Crystal Structure of Oligoribonuclease, the lone essential exoribonuclease in Escherichia coli 分子名称: CITRATE ANION, Oligoribonuclease 著者 Fiedler, T.J, Zuo, Y, Malhotra, A. 登録日 2005-02-10 公開日 2006-02-14 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of Oligoribonuclease, the lone essential exoribonuclease in Escherichia coli To be Published
7AXI	Crystal structure of the hPXR-LBD in complex with estradiol and cis-chlordane 分子名称: (+)cis-chlordane, (-)cis-chlordane, (4S)-2-METHYL-2,4-PENTANEDIOL, ... 著者 Huet, T, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
3PY7	Crystal structure of full-length Bovine Papillomavirus oncoprotein E6 in complex with LD1 motif of paxillin at 2.3A resolution 分子名称: ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, maltose-binding periplasmic protein,paxillin LD1,protein E6 chimera 著者 Cavarelli, J. 登録日 2010-12-12 公開日 2011-12-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.288 Å) 主引用文献 Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science, 339, 2013
7AXA	Crystal structure of the hPXR-LBD in complex with clotrimazole 分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Nuclear receptor subfamily 1 group I member 2 著者 Delfosse, V, Granell, M, Blanc, P, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AXF	Crystal structure of the hPXR-LBD in complex with pretilachlor 分子名称: ISOPROPYL ALCOHOL, Nuclear receptor subfamily 1 group I member 2, pretilachlor 著者 Harrus, D, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
4NED	Crystal STRUCTURE OF C-LOBE OF BOVINE LACTOFERRIN COMPLEXED WITH FENOPROFEN AT 2.1 ANGSTROM RESOLUTION 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, ... 著者 Gautam, L, Dube, D, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. 登録日 2013-10-29 公開日 2013-12-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal STRUCTURE OF C-LOBE OF BOVINE LACTOFERRIN COMPLEXED WITH FENOPROFEN AT 2.1 ANGSTROM RESOLUTION To be Published
4A7C	Crystal structure of PIM1 kinase with ETP46546 分子名称: ACETATE ION, IMIDAZOLE, N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethyloxy)phenyl]-[1,2,3]triazolo[4,5-b]pyridin-5-amine, ... 著者 Mazzorana, M, Montoya, G. 登録日 2011-11-12 公開日 2012-02-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Hit to Lead Evaluation of 1,2,3-Triazolo[4,5-B]Pyridines as Pim Kinase Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
6L17	Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives 分子名称: 7-chloranyl-5-[3-[(3~{S})-piperidin-3-yl]propyl]pyrido[3,4-b][1,4]benzoxazin-8-amine, Serine/threonine-protein kinase pim-1 著者 Zhang, W, Xie, Y, Cao, R, Huang, N, Zhou, Y. 登録日 2019-09-27 公開日 2020-09-02 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
4FV3	Crystal Structure of the ERK2 complexed with EK6 分子名称: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Kang, Y.N, Stuckey, J.A, Xie, X. 登録日 2012-06-29 公開日 2012-08-29 最終更新日 2014-09-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of the ERK2 complexed with EK6 TO BE PUBLISHED

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