8K7I
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![BU of 8k7i by Molmil](/molmil-images/mine/8k7i) | Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2-(hydroxymethyl)-5-((methylamino)methyl)pyrrolidine-3,4-diol | 分子名称: | (2~{R},3~{S},4~{R},5~{R})-2-(hydroxymethyl)-5-(methylaminomethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. | 登録日 | 2023-07-26 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024
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8K77
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![BU of 8k77 by Molmil](/molmil-images/mine/8k77) | Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and brivaracetam | 分子名称: | (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yamagata, A. | 登録日 | 2023-07-26 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15, 2024
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8K73
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![BU of 8k73 by Molmil](/molmil-images/mine/8k73) | Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((1-(phenylsulfonyl)pyrrolidine-3-carbonyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid | 分子名称: | 2-[(2~{Z})-3-oxidanyl-2-[(3~{R})-1-(phenylsulfonyl)pyrrolidin-3-yl]carbonylimino-1,3-thiazol-4-yl]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... | 著者 | Nakashima, Y, Corner, T.P, Teo, R.Z.R, Brewitz, L, Schofield, C.J. | 登録日 | 2023-07-26 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-alpha. Chem Sci, 14, 2023
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8K72
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![BU of 8k72 by Molmil](/molmil-images/mine/8k72) | Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((3-(phenylsulfonamido)propanoyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid | 分子名称: | 2-[(2~{Z})-3-oxidanyl-2-[3-(phenylsulfonylamino)propanoylimino]-1,3-thiazol-4-yl]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... | 著者 | Nakashima, Y, Corner, T.P, Teo, R.Z.R, Brewitz, L, Schofield, C.J. | 登録日 | 2023-07-26 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-alpha. Chem Sci, 14, 2023
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8K71
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![BU of 8k71 by Molmil](/molmil-images/mine/8k71) | Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((2-((naphthalen-2-ylmethyl)sulfonyl)acetyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid | 分子名称: | 2-[(2~{Z})-2-[2-(naphthalen-2-ylmethylsulfonyl)ethanoylimino]-3-oxidanyl-1,3-thiazol-4-yl]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... | 著者 | Nakashima, Y, Corner, T.P, Teo, R.Z.R, Brewitz, L, Schofield, C.J. | 登録日 | 2023-07-26 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-alpha. Chem Sci, 14, 2023
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8K70
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8K6Z
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![BU of 8k6z by Molmil](/molmil-images/mine/8k6z) | NMR structure of human leptin | 分子名称: | Leptin | 著者 | Fan, X, Qin, R, Yuan, W, Fan, J, Huang, W, Lin, Z. | 登録日 | 2023-07-26 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of human leptin reveals a conformational plasticity important for receptor recognition. Structure, 32, 2024
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8K6Y
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![BU of 8k6y by Molmil](/molmil-images/mine/8k6y) | Serial femtosecond crystallography structure of photo dissociated CO from ba3- type cytochrome c oxidase determined by extrapolation method | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CARBON MONOXIDE, COPPER (II) ION, ... | 著者 | Safari, C, Ghosh, S, Andersson, R, Johannesson, J, Donoso, A.V, Zoric, D, Sandelin, E, Iwata, S, Neutze, R, Branden, G. | 登録日 | 2023-07-25 | 公開日 | 2023-11-15 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase. Sci Adv, 9, 2023
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8K6T
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![BU of 8k6t by Molmil](/molmil-images/mine/8k6t) | The minor pilin structure of FctB3 in Streptococcus | 分子名称: | FctB3, GLYCEROL | 著者 | Takebe, K, Sangawa, T, Suzuki, M, Nakata, M. | 登録日 | 2023-07-25 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms. Arch.Microbiol., 206, 2023
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8K6Q
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![BU of 8k6q by Molmil](/molmil-images/mine/8k6q) | Crystal structure of HOIL-1L LTM domain | 分子名称: | RanBP-type and C3HC4-type zinc finger-containing protein 1 | 著者 | Yan, Z, Pan, L.F. | 登録日 | 2023-07-25 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN. Biochem.Biophys.Res.Commun., 689, 2023
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8K6P
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8K6K
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![BU of 8k6k by Molmil](/molmil-images/mine/8k6k) | Cryo-EM Structure of Membrane-bound Fructose Dehydrogenase from Gluconobacter japonicus variant-N1146A | 分子名称: | FE3-S4 CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, Fructose dehydrogenase (N1146A) large subunit, ... | 著者 | Fukawa, E, Miyata, T, Makino, F, Adachi, T, Suzuki, Y, Tanaka, H, Namba, K, Sowa, K, Kitazumi, Y, Shirai, O. | 登録日 | 2023-07-25 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural and electrochemical elucidation of biocatalytic mechanisms in direct electron transfer-type D-fructose dehydrogenase. Electrochim Acta, 490, 2024
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8K6J
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![BU of 8k6j by Molmil](/molmil-images/mine/8k6j) | Cryo-EM Structure of Membrane-bound Fructose Dehydrogenase from Gluconobacter japonicus variant-H1147A | 分子名称: | FE3-S4 CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, Fructose dehydrogenase (H1147A) large subunit, ... | 著者 | Fukawa, E, Miyata, T, Makino, F, Adachi, T, Suzuki, Y, Tanaka, H, Namba, K, Sowa, K, Kitazumi, Y, Shirai, O. | 登録日 | 2023-07-25 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structural and electrochemical elucidation of biocatalytic mechanisms in direct electron transfer-type D-fructose dehydrogenase. Electrochim Acta, 490, 2024
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8K6B
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8K65
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![BU of 8k65 by Molmil](/molmil-images/mine/8k65) | Serial femtosecond crystallography structure of CO bound ba3- type cytochrome c oxidase without pump laser irradiation | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CARBON MONOXIDE, COPPER (II) ION, ... | 著者 | Safari, C, Ghosh, S, Andersson, R, Johannesson, J, Donoso, A.V, Bath, P, Zoric, D, Sandelin, E, Nango, E, Tanaka, R, Iwata, S, Neutze, R, Branden, G. | 登録日 | 2023-07-25 | 公開日 | 2023-11-15 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase. Sci Adv, 9, 2023
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8K5Y
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![BU of 8k5y by Molmil](/molmil-images/mine/8k5y) | Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor | 分子名称: | (3-azanyl-4-fluoranyl-5,7,8,9-tetrahydropyrido[4,3-c]azepin-6-yl)-[6-(2-oxidanylpropan-2-yl)-1H-indol-2-yl]methanone, CALCIUM ION, DIHYDROGENPHOSPHATE ION, ... | 著者 | Kamitani, M, Mima, M, Nishikawa-Shimono, R. | 登録日 | 2023-07-24 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation. Bioorg.Med.Chem.Lett., 97, 2023
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8K5R
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![BU of 8k5r by Molmil](/molmil-images/mine/8k5r) | CDK9/cyclin T1 in complex with KB-0742 | 分子名称: | (1S,3S)-N3-(5-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine, Cyclin-T1, Cyclin-dependent kinase 9 | 著者 | Zhou, M, Li, H, Gao, H, Trotter, B.W, Freeman, D. | 登録日 | 2023-07-24 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.751 Å) | 主引用文献 | Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers. J.Med.Chem., 66, 2023
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8K5O
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![BU of 8k5o by Molmil](/molmil-images/mine/8k5o) | Cryo-EM structure of the RC-LH core comples from Halorhodospira halochloris | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-O-octyl-beta-D-glucopyranose, ... | 著者 | Wang, G.-L, Qi, C.-H, Yu, L.-J. | 登録日 | 2023-07-22 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | 主引用文献 | Structural insights into the unusual core photocomplex from a triply extremophilic purple bacterium, Halorhodospira halochloris. J Integr Plant Biol, 2024
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8K5K
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![BU of 8k5k by Molmil](/molmil-images/mine/8k5k) | The structure of SenA | 分子名称: | FE (III) ION, GLYCEROL, selenoneine synthase SenA | 著者 | Liu, M, Yang, Y, Huang, J.-W, Chen, C.-C, Guo, R.-T. | 登録日 | 2023-07-21 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural insights into a novel nonheme iron-dependent oxygenase in selenoneine biosynthesis. Int.J.Biol.Macromol., 256, 2023
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8K5J
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![BU of 8k5j by Molmil](/molmil-images/mine/8k5j) | The structure of SenA in complex with N,N,N-trimethyl-histidine | 分子名称: | FE (III) ION, GLYCEROL, N,N,N-trimethyl-histidine, ... | 著者 | Liu, M, Yang, Y, Huang, J.-W, Chen, C.-C, Guo, R.-T. | 登録日 | 2023-07-21 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structural insights into a novel nonheme iron-dependent oxygenase in selenoneine biosynthesis. Int.J.Biol.Macromol., 256, 2023
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8K5I
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![BU of 8k5i by Molmil](/molmil-images/mine/8k5i) | The structure of SenA in complex with N,N,N-trimethyl-histidine and thioglucose | 分子名称: | 1-thio-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, FE (III) ION, ... | 著者 | Liu, M, Yang, Y, Huang, J.-W, Chen, C.-C, Guo, R.-T. | 登録日 | 2023-07-21 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural insights into a novel nonheme iron-dependent oxygenase in selenoneine biosynthesis. Int.J.Biol.Macromol., 256, 2023
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8K5H
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![BU of 8k5h by Molmil](/molmil-images/mine/8k5h) | Structure of the SARS-CoV-2 BA.1 spike with UT28-RD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Chen, L, Kita, S, Anraku, Y, Maenaka, K. | 登録日 | 2023-07-21 | 公開日 | 2023-12-27 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1. Structure, 32, 2024
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8K5G
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![BU of 8k5g by Molmil](/molmil-images/mine/8k5g) | Structure of the SARS-CoV-2 BA.1 RBD with UT28-RD | 分子名称: | Spike protein S1, UT28K-RD Fab Heavy chain, UT28K-RD Fab Light chain | 著者 | Chen, L, Kita, S, Anraku, Y, Maenaka, K. | 登録日 | 2023-07-21 | 公開日 | 2023-12-27 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1. Structure, 32, 2024
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8K4Z
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8K4R
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![BU of 8k4r by Molmil](/molmil-images/mine/8k4r) | Structure of VinM-VinL complex | 分子名称: | Acyl-carrier-protein, Non-ribosomal peptide synthetase, SODIUM ION, ... | 著者 | Miyanaga, A, Nagata, K, Nakajima, J, Chisuga, T, Kudo, F, Eguchi, T. | 登録日 | 2023-07-20 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis of Amide-Forming Adenylation Enzyme VinM in Vicenistatin Biosynthesis. Acs Chem.Biol., 18, 2023
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