PDB: 31489 件ウェブページステータス検索Chemie searchBIRD

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6HPY	Crystal structure of ENL (MLLT1) in complex with compound 12 分子名称: 1,2-ETHANEDIOL, 3-[4-[(4-~{tert}-butylphenyl)carbonylamino]phenyl]propanoic acid, Protein ENL, ... 著者 Heidenreich, D, Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2018-09-22 公開日 2018-11-28 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). J.Med.Chem., 61, 2018
6HQ6	Bacterial beta-1,3-oligosaccharide phosphorylase from GH149 分子名称: 1,2-ETHANEDIOL, BICINE, Bacterial beta-1,3-oligosaccharide phosphorylase, ... 著者 Kuhaudomlarp, S, Stevenson, C.E.M, Lawson, D.M, Field, R.A. 登録日 2018-09-24 公開日 2019-06-12 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The structure of a GH149 beta-(1 → 3) glucan phosphorylase reveals a new surface oligosaccharide binding site and additional domains that are absent in the disaccharide-specific GH94 glucose-beta-(1 → 3)-glucose (laminaribiose) phosphorylase. Proteins, 87, 2019
7MHE	Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7957 分子名称: 1,2-ETHANEDIOL, 4-{4-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]benzene-1-sulfonyl}morpholine, Fatty acid synthase 著者 Aleshin, A.E, Lambert, L, Liddington, R.C, Cosford, N. 登録日 2021-04-15 公開日 2022-04-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635 To Be Published
6HR6	Nitrocefin reacted with catalytic serine (Ser294) of penicillin-binding protein 3 from Pseudomonas aeruginosa 分子名称: Nitrocefin - open form, Peptidoglycan D,D-transpeptidase FtsI 著者 Bellini, D, Dowson, C.G. 登録日 2018-09-26 公開日 2019-10-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Nitrocefin acylation of single catalytic serine of penicillin-binding protein 3 from P. aeruginosa To Be Published
8TRP	Structure of a HEPES bound TRAP transporter substrate binding protein. 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Isethionate-binding periplasmic protein DctP 著者 Newton-Vesty, M.C, Dobson, R.C.J. 登録日 2023-08-10 公開日 2024-08-28 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structure of a HEPES bound TRAP transporter substrate binding protein. To Be Published
8BCT	X-ray crystal structure of a de novo selected helix-loop-helix heterodimer in a syn arrangement, 26alpha/26beta 分子名称: 26alpha, 26beta, ACETATE ION, ... 著者 Naudin, E.A, Mylemans, B, Smith, A.J, Savery, N.J, Woolfson, D.N. 登録日 2022-10-17 公開日 2023-06-07 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Design and Selection of Heterodimerizing Helical Hairpins for Synthetic Biology. Acs Synth Biol, 12, 2023
8BOQ	A. vinelandii Fe-nitrogenase FeFe protein 分子名称: 3-HYDROXY-3-CARBOXY-ADIPIC ACID, FE(8)-S(7) CLUSTER, Fe-only nitrogenase, ... 著者 Trncik, C, Detemple, F, Einsle, O. 登録日 2022-11-15 公開日 2023-06-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.547 Å) 主引用文献 Iron-only Fe-nitrogenase underscores common catalytic principles in biological nitrogen fixation Nat Catal, 2023
8TY5	MI-14 bound to Mpro of SARS-CoV-2 分子名称: (1R,2S,5S)-3-[(2,4-dichlorophenoxy)acetyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 著者 Blankenship, L.R, Liu, W.R. 登録日 2023-08-24 公開日 2024-08-28 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 MI-14 bound to SARS-CoV-2 Mpro To Be Published
8BDB	Ribulose-1,5-bisphosphate carboxylase/oxygenase from Griffithsia monilis 分子名称: 1,2-ETHANEDIOL, 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, BICARBONATE ION, ... 著者 Andersson, I, Gunn, L.H. 登録日 2022-10-19 公開日 2023-06-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Grafting Rhodobacter sphaeroides with red algae Rubisco to accelerate catalysis and plant growth. Nat.Plants, 9, 2023
6DOM	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 50 mM K+ for 120 s at 21 C 分子名称: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of cleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', 5'-R(P*CP*G)-3' portion of cleaved RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.425 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
8BI2	Syk kinase domain in complex with macrocyclic inhibitor 20a 分子名称: 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one, Tyrosine-protein kinase SYK 著者 Read, J.A, Patel, J. 登録日 2022-11-01 公開日 2023-06-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.508 Å) 主引用文献 Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors. Bioorg.Med.Chem.Lett., 91, 2023
6HYG	Heteromeric tandem IgG4/IgG1 Fc 分子名称: IgHG1 and IgHG4 hybrid, ZINC ION 著者 Casaletto, J.B, Geddie, M.L, Abu-Yousif, A.O, Masson, K, Fulgham, A, Boudot, A, Maiwald, T, Kearns, J.D, Kohli, N, Su, S, Razlog, M, Raue, A, Kalra, A, Hakansson, M, Logan, D.T, Welin, M, Chattopadhyay, S, Harms, B.D, Nielsen, U.B, Schoeberl, B, Lugovskoy, A.A, MacBeath, G. 登録日 2018-10-21 公開日 2019-03-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Proc.Natl.Acad.Sci.USA, 116, 2019
8BTW	Structure of D179N BlaC from Mycobacterium tuberculosis in complex with vaborbactam 分子名称: Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... 著者 Chikunova, A, Bruenle, S, Ubbink, M. 登録日 2022-12-02 公開日 2023-07-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis. Febs J., 290, 2023
6HYI	Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.4 A resolution in complex with inosine 分子名称: INOSINE, Protein kinase A regulatory subunit 著者 Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. 登録日 2018-10-22 公開日 2019-11-13 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.39944851 Å) 主引用文献 Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens. Elife, 12, 2024
6DP2	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 7.5 mM Mg2+ and 75 mM K+ for 40 s at 21 C 分子名称: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of uncleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', 5'-R(P*CP*G)-3' portion of uncleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.662 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
6HYQ	Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi bound to guanosine 分子名称: ACETATE ION, GUANOSINE, Protein kinase A regulatory subunit 著者 Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. 登録日 2018-10-22 公開日 2019-11-13 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi in complex with guanosine to be published
6DPO	Crystal Structure of Bacillus Halodurans Ribonuclease H1 E188A in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 200 mM K+ for 360 s at 21 C 分子名称: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of cleaved RNA 5'-R(*AP*CP*AP*UP*CP*G)-3', 5'-R(P*CP*G)-3' portion of cleaved RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
7MLK	Crystal structure of human PI3Ka (p110a subunit) with MMV085400 bound to the active site determined at 2.9 angstroms resolution 分子名称: 4-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]benzamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Krake, S.H, Martinez, P.D.G, Poggi, M.L, Ferreira, M.S, Aguiar, A.C.C, Souza, G.E, Wenlock, M, Jones, B, Steinbrecher, T, Day, T, McPhail, J, Burke, J, Yeo, T, Mok, S, Uhlemann, A.C, Fidock, D.A, Chen, P, Grodsky, N, Deng, Y.L, Guido, R.V.C, Campbell, S.F, Willis, P.A, Dias, L.C. 登録日 2021-04-28 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Discovery of 2,6-disubstituted pyrazines as potent PI4K inhibitors with antimalarial activity To Be Published
6I0P	Structure of quinolinate synthase in complex with 6-mercaptopyridine-2,3-dicarboxylic acid 分子名称: 6-mercaptopyridine-2,3-dicarboxylic acid, CHLORIDE ION, IRON/SULFUR CLUSTER, ... 著者 Volbeda, A, Fontecilla-Camps, J.C. 登録日 2018-10-26 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination. Chem.Commun.(Camb.), 55, 2019
8B1P	Crystal structure of SUDV VP40 CCS mutant 分子名称: Matrix protein VP40 著者 Werner, A.-D, Becker, S. 登録日 2022-09-11 公開日 2023-06-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The C-terminus of Sudan ebolavirus VP40 contains a functionally important CX n C motif, a target for redox modifications. Structure, 31, 2023
8B3X	High resolution crystal structure of dimeric SUDV VP40 分子名称: Matrix protein VP40 著者 Werner, A.-D, Norris, M, Saphire, E.O, Becker, S. 登録日 2022-09-17 公開日 2023-06-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.531 Å) 主引用文献 The C-terminus of Sudan ebolavirus VP40 contains a functionally important CX n C motif, a target for redox modifications. Structure, 31, 2023
6HVO	Crystal structure of human PCNA in complex with three peptides of p12 subunit of human polymerase delta 分子名称: DNA polymerase delta subunit 4, Proliferating cell nuclear antigen, SULFATE ION 著者 Gonzalez-Magana, A, Romano-Moreno, M, Rojas, A.L, Blanco, F.J, De Biasio, A. 登録日 2018-10-11 公開日 2019-01-23 最終更新日 2019-03-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The p12 subunit of human polymerase delta uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA). J.Biol.Chem., 294, 2019
8U1Y	E.coli DsbA in complex with N-(4-(thiophen-3-yl)benzyl)cyclohexanamine 分子名称: COPPER (II) ION, Thiol:disulfide interchange protein DsbA, ~{N}-[(4-thiophen-3-ylphenyl)methyl]cyclohexanamine 著者 Wang, G, Heras, B. 登録日 2023-09-04 公開日 2024-09-11 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Two-mode inhibition of DsbA: combination of two site-specific inhibitors enhances virulence inhibition in Salmonella enterica serovar Typhimurium To Be Published
8BAR	E. coli C7 DarT1 in complex with ADP-ribosylated ssDNA and nicotinamide 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5-DIPHOSPHORIBOSE, DNA (5'-D(*AP*AP*GP*AP*C)-3'), ... 著者 Schuller, M, Ariza, A. 登録日 2022-10-11 公開日 2023-07-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Molecular basis for the reversible ADP-ribosylation of guanosine bases. Mol.Cell, 83, 2023
8B1O	Crystal structure of SUDV VP40 C314S mutant 分子名称: Matrix protein VP40 著者 Werner, A.-D, Becker, S. 登録日 2022-09-11 公開日 2023-06-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The C-terminus of Sudan ebolavirus VP40 contains a functionally important CX n C motif, a target for redox modifications. Structure, 31, 2023

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