PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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6W52	Prefusion RSV F bound by neutralizing antibody RSB1 分子名称: Fusion glycoprotein F0, Fusion glycoprotein F1 fused with Fibritin trimerization domain, RSB1 Fab Heavy Chain, ... 著者 Harshbarger, W, Chandramouli, S, Malito, M. 登録日 2020-03-12 公開日 2020-11-11 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (3.74 Å) 主引用文献 Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F. Plos Pathog., 16, 2020
1ZN8	Human Adenine Phosphoribosyltransferase Complexed with AMP, in Space Group P1 at 1.76 A Resolution 分子名称: ADENOSINE MONOPHOSPHATE, Adenine phosphoribosyltransferase, CHLORIDE ION 著者 Iulek, J, Silva, M, Tomich, C.H.T.P, Thiemann, O.H. 登録日 2005-05-11 公開日 2006-04-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structural Complexes of Human Adenine Phosphoribosyltransferase Reveal Novel Features of the APRT Catalytic Mechanism J.Biomol.Struct.Dyn., 25, 2008
7SK6	Cryo-EM structure of human ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ and an intracellular Fab 分子名称: Atypical chemokine receptor 3, CID24 Fab heavy chain, CID24 Fab light chain, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 最終更新日 2024-11-20 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7JFQ	The crystal structure of 3CL MainPro of SARS-CoV-2 with de-oxidized C145 分子名称: 1,2-ETHANEDIOL, 3C-like proteinase, FORMIC ACID 著者 Tan, K, Maltseva, N.I, Welk, L.F, Jedrzejczak, R.P, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2020-07-17 公開日 2020-07-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 The crystal structure of 3CL MainPro of SARS-CoV-2 with de-oxidized C145 To Be Published
7SK3	Cryo-EM structure of ACKR3 in complex with CXCL12, an intracellular Fab, and an extracellular Fab 分子名称: Atypical chemokine receptor 3, CHOLESTEROL, CID24 Fab heavy chain, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7SK8	Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, an extracellular Fab, and an intracellular Fab 分子名称: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Atypical chemokine receptor 3, CHOLESTEROL, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
6DDD	Structure of the 50S ribosomal subunit from Methicillin Resistant Staphylococcus aureus in complex with the oxazolidinone antibiotic LZD-5 分子名称: 2,2-dichloro-N-({(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide, 23S rRNA, 50S ribosomal protein L13, ... 著者 Belousoff, M.J, Venugopal, H, Bamert, R.S, Lithgow, T. 登録日 2018-05-10 公開日 2019-03-20 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 cryoEM-Guided Development of Antibiotics for Drug-Resistant Bacteria. ChemMedChem, 14, 2019
6DIM	Crystal structure of Tdp1 catalytic domain in complex with Zenobia fragment ZT1982 from cocktail soak 分子名称: 1,2-ETHANEDIOL, 4-hydroxyquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 著者 Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. 登録日 2018-05-23 公開日 2019-05-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019
7SK7	Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, and an extracellular Fab 分子名称: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Anti-Fab nanobody, Atypical chemokine receptor 3, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 最終更新日 2024-11-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7SK5	Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab 分子名称: Anti-Fab nanobody, Atypical chemokine receptor 3, CHOLESTEROL, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 最終更新日 2025-06-04 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
4RAZ	Crystal structure of Magnetospirillum gryphiswaldense MSR-1 holo-Fur 分子名称: 1,2-ETHANEDIOL, DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport(Fur family), MANGANESE (II) ION 著者 Deng, Z, Wang, Q, Chen, Z. 登録日 2014-09-12 公開日 2015-07-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Nat Commun, 6
7JHP	Crystal structure of HRas in complex with the Ras-binding and cysteine-rich domains of CRaf-kinase 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Cookis, T, Mattos, C. 登録日 2020-07-21 公開日 2020-08-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.766 Å) 主引用文献 Crystal Structure Reveals the Full Ras-Raf Interface and Advances Mechanistic Understanding of Raf Activation. Biomolecules, 11, 2021
7JN0	Sheep Connexin-46 at 2.5 angstroms resolution, Lipid Class 2 分子名称: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Gap junction alpha-3 protein 著者 Flores, J.A, Haddad, B.G, Dolan, K.A, Myers, J.A, Yoshioka, C.C, Copperman, J, Zuckerman, D.M, Reichow, S.L. 登録日 2020-08-03 公開日 2020-09-09 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 angstrom. Nat Commun, 11, 2020
5BW9	Crystal Structure of Yeast V1-ATPase in the Autoinhibited Form 分子名称: V-type proton ATPase catalytic subunit A, V-type proton ATPase subunit B, V-type proton ATPase subunit D, ... 著者 Oot, R.A, Kane, P.M, Berry, E.A, Wilkens, S. 登録日 2015-06-06 公開日 2016-06-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (7 Å) 主引用文献 Crystal structure of yeast V1-ATPase in the autoinhibited state. Embo J., 35, 2016
6U81	Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*AP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*AP*TP*TP*AP*GP*CP*CP*CP*AP*TP*TP*AP*CP*GP*C)-3'), ... 著者 Shi, K, Aihara, H. 登録日 2019-09-04 公開日 2020-02-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD. Faseb J., 34, 2020
6U9S	Crystal structure of human CD81 large extracellular loop in complex with 5A6 Fab 分子名称: 5A6 FAB Heavy Chain, 5A6 FAB Light Chain, CD81 antigen, ... 著者 Susa, K.J, Seegar, T.C.M, Blacklow, S.C.B, Kruse, A.C. 登録日 2019-09-09 公開日 2020-05-13 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. Elife, 9, 2020
6UBS	Full length Glycine receptor reconstituted in lipid nanodisc in Apo/Resting conformation 分子名称: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1, ... 著者 Kumar, A, Basak, S, Chakrapani, S. 登録日 2019-09-12 公開日 2020-07-29 最終更新日 2024-11-20 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs. Nat Commun, 11, 2020
4JE3	An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation 分子名称: Central kinetochore subunit CHL4, Central kinetochore subunit IML3 著者 Hinshaw, S.M, Harrison, S.C. 登録日 2013-02-26 公開日 2013-10-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.282 Å) 主引用文献 An iml3-chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation. Cell Rep, 5, 2013
4RE9	Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-5-yl}methyl)benzamide, ... 著者 Liang, W.G, Deprez, R, Deprez, B, Tang, W.J. 登録日 2014-09-22 公開日 2015-09-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.908 Å) 主引用文献 Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun, 6, 2015
7QRW	Crystal structure of NHL domain of TRIM3 分子名称: GLYCEROL, Isoform 4 of Tripartite motif-containing protein 3, SULFATE ION 著者 Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2022-01-12 公開日 2022-05-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Comparative structural analyses of the NHL domains from the human E3 ligase TRIM-NHL family. Iucrj, 9, 2022
6YKK	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 15 分子名称: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... 著者 Pang, L, Strelkov, S.V, Weeks, S.D. 登録日 2020-04-06 公開日 2020-12-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.236 Å) 主引用文献 Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6YKV	Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound 11g 分子名称: 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... 著者 Pang, L, Strelkov, S.V, Weeks, S.D. 登録日 2020-04-06 公開日 2020-12-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors. Eur.J.Med.Chem., 211, 2021
6DAT	ETS1 in complex with synthetic SRR mimic 分子名称: Protein C-ets-1, SULFATE ION, serine-rich region (SRR) peptide 著者 Perez-Borrajero, C, Okon, M, Lin, C.S, Scheu, K, Murphy, M.E.P, Graves, B.J, McIntosh, L.P. 登録日 2018-05-02 公開日 2019-01-16 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.35002637 Å) 主引用文献 The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor. J. Mol. Biol., 431, 2019
6D84	Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer 分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... 著者 Buffalo, C.Z, Morris, K.L, Hurley, J.H. 登録日 2018-04-25 公開日 2018-08-08 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (6.72 Å) 主引用文献 HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell, 174, 2018
4QR6	Human Aldose Reductase complexed with a ligand with an IDD structure (2-[2-(1,3-benzothiazol-2-ylmethylcarbamoyl)-5-fluoro-phenoxy]acetic acid) at 1.05 A 分子名称: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {2-[(1,3-benzothiazol-2-ylmethyl)carbamoyl]-5-fluorophenoxy}acetic acid 著者 Rechlin, C, Heine, A, Klebe, G. 登録日 2014-06-30 公開日 2015-08-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation To be Published

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