PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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4HN5	GR DNA Binding Domain - TSLP nGRE Complex 分子名称: DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ... 著者 Hudson, W.H, Youn, C.E, Ortlund, E.A. 登録日 2012-10-18 公開日 2012-12-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.902 Å) 主引用文献 The structural basis of direct glucocorticoid-mediated transrepression. Nat.Struct.Mol.Biol., 20, 2013
6UBT	Full length Glycine receptor reconstituted in lipid nanodisc in Gly-bound desensitized conformation 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alphaZ1 著者 Kumar, A, Basak, S, Chakrapani, S. 登録日 2019-09-12 公開日 2020-07-29 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.55 Å) 主引用文献 Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs. Nat Commun, 11, 2020
4ZOP	Co-crystal Structure of Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor 分子名称: (2S,3R)-N~1~-(8-tert-butyl-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Knapp, M.S, Elling, R.A. 登録日 2015-05-06 公開日 2016-05-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Co-crystal Structure of the Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitorCo-crystal Structure of the Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor To Be Published
4QBX	Human Aldose Reductase complexed with a ligand with an IDD structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) at 0.98 A 分子名称: Aldose reductase, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Rechlin, C, Heine, A, Klebe, G. 登録日 2014-05-09 公開日 2015-07-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (0.98 Å) 主引用文献 Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation To be Published
6CRC	Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CCL2, beta, gamma dATP analogue 分子名称: 2'-deoxy-5'-O-[(R)-{[(R)-[dichloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]adenosine, DNA polymerase beta, Downstream Primer Strand, ... 著者 Batra, V.K, Wilson, S.H. 登録日 2018-03-16 公開日 2018-07-25 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry, 57, 2018
7P2Z	Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with cyclosulfamidate 4 分子名称: (3~{a}~{R},4~{S},5~{S},6~{S},7~{R},7~{a}~{S})-7-(hydroxymethyl)-2,2-bis(oxidanylidene)-3~{a},4,5,6,7,7~{a}-hexahydro-3~{H}-benzo[d][1,2,3]oxathiazole-4,5,6-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Roig-Zamboni, V, Kok, K, Overkleeft, H, Artola, M, Sulzenbacher, G. 登録日 2021-07-06 公開日 2022-07-13 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 1,6- epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal alpha-Glucosidase Stabilizer for the Treatment of Pompe Disease. J.Am.Chem.Soc., 144, 2022
2A3B	Crystal structure of Aspergillus fumigatus chitinase B1 in complex with caffeine 分子名称: CAFFEINE, SULFATE ION, chitinase 著者 Rao, F.V, Andersen, O.A, Vora, K.A, DeMartino, J.A, van Aalten, D.M.F. 登録日 2005-06-24 公開日 2005-09-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes. Chem.Biol., 12, 2005
6CS1	SARS Spike Glycoprotein, Trypsin-cleaved, Stabilized variant, two S1 CTDs in an upwards conformation 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ... 著者 Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B. 登録日 2018-03-19 公開日 2018-04-11 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis. Sci Rep, 8, 2018
4Q99	Crystal structure of 2-mercapto-4-methylphenol bound to human carbonic anhydrase II 分子名称: 4-methyl-2-sulfanylphenol, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Martin, D.P, Cohen, S.M. 登録日 2014-04-29 公開日 2015-03-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Exploring the influence of the protein environment on metal-binding pharmacophores. J.Med.Chem., 57, 2014
6CSW	Crystal Structure of the Human vaccinia-related kinase bound to a N-methyl-N-propyl-dihydropteridine inhibitor 分子名称: (7R)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-7,8-dihydropteridin-6(5H)-one, ACETATE ION, CHLORIDE ION, ... 著者 dos Reis, C.V, de Souza, G.P, Counago, R.M, Chiodi, C.G, Azevedo, A, Guimaraes, C, Mascarello, A, Gama, F, Ferreira, M, Massirer, K.B, Arruda, P, Edwards, A.M, Elkins, J.M, Structural Genomics Consortium (SGC) 登録日 2018-03-21 公開日 2018-04-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal Structure of the Human vaccinia-related kinase bound to a N-methyl-N-propyl-dihydropteridine inhibitor To Be Published
6CTP	Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CH2, beta, gamma dTTP analogue 分子名称: CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2018-03-23 公開日 2018-06-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry, 57, 2018
6CMM	Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine inhibitor 分子名称: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... 著者 dos Reis, C.V, de Souza, G.P, Counago, R.M, Azevedo, A, Guimaraes, C, Mascarello, A, Gama, F, Ferreira, M, Massirer, K.B, Arruda, P, Edwards, A.M, Elkins, J.M, Structural Genomics Consortium (SGC) 登録日 2018-03-05 公開日 2018-03-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine inhibitor To Be Published
6CN8	High-resolution structure of ClpC1-NTD binding to Rufomycin-I 分子名称: ATP-dependent Clp protease ATP-binding subunit ClpC1, CHLORIDE ION, PHOSPHATE ION, ... 著者 Abad-Zapatero, C, Wolf, N.W. 登録日 2018-03-07 公開日 2019-06-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads. Acs Infect Dis., 5, 2019
6UHS	Open-form Crystal Structure of Chimera Bt-hRyR_12 from Bacteroides thetaiotaomicron /human 分子名称: Ryanodine receptor 1 chimera 著者 Wu, R, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2019-09-27 公開日 2020-09-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Open-form Crystal Structure of Chimera Bt-hRyR_12 from Bacteroides thetaiotaomicron /human To Be Published
6CNC	Yeast RNA polymerase III open complex 分子名称: DNA (71-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... 著者 Han, Y, He, Y. 登録日 2018-03-08 公開日 2018-08-22 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural visualization of RNA polymerase III transcription machineries. Cell Discov, 4, 2018
4QDE	Dcps in complex with covalent inhibitor 分子名称: 2-{[(2,4-diaminoquinazolin-5-yl)oxy]methyl}benzenesulfonic acid, PHOSPHATE ION, m7GpppX diphosphatase 著者 Liu, S. 登録日 2014-05-13 公開日 2015-05-13 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Dcps in complex with covalent inhibitors To be Published
6CR9	Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CFCL, beta, gamma dATP analogue 分子名称: 9-{5-O-[(R)-{[(R)-[(S)-chloro(fluoro)phosphonomethyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-deoxy-alpha-D-threo-pentofuranosyl}-9H-purin-6-amine, CHLORIDE ION, DNA polymerase beta, ... 著者 Batra, V.K, Wilson, S.H. 登録日 2018-03-16 公開日 2018-07-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry, 57, 2018
7P32	Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with cyclosulfamidate 6 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Roig-Zamboni, V, Kok, K, Overkleeft, H, Artola, M, Sulzenbacher, G. 登録日 2021-07-06 公開日 2022-07-13 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 1,6- epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal alpha-Glucosidase Stabilizer for the Treatment of Pompe Disease. J.Am.Chem.Soc., 144, 2022
4QF3	Crystal structure of human BAZ2B PHD zinc finger in the free form 分子名称: Bromodomain adjacent to zinc finger domain protein 2B, ZINC ION 著者 Tallant, C, Van Molle, I, Chirgadze, D.Y, Ciulli, A. 登録日 2014-05-19 公開日 2014-07-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC. Structure, 23, 2015
7RZN	Crystal Structure of Ferritin grown by microbatch method in presence of agarose and electric field 2.1KV 分子名称: CADMIUM ION, Ferritin light chain, SULFATE ION 著者 Aditya, S, Priyadharshine, R, Maham, I, Miller, J.D, Stojanoff, V. 登録日 2021-08-27 公開日 2022-11-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Crystal Structure of Ferritin grown by microbatch method in presence of agarose and electric field 2.1KV To Be Published
6CYV	E. coli DHFR ternary complex with NADP and dihydrofolate 分子名称: DIHYDROFOLIC ACID, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. 登録日 2018-04-06 公開日 2019-01-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release. Commun Biol, 1, 2018
6ULO	Structure of an N-terminally truncated uncharacterized protein from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Copenhageni (strain Fiocruz L1-130) 分子名称: CHLORIDE ION, Uncharacterized protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2019-10-08 公開日 2019-10-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure of an N-terminally truncated uncharacterized protein from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Copenhageni (strain Fiocruz L1-130) to be published
6TX8	CRYSTAL STRUCTURE OF HUMAN FKBP51 FK1 DOMAIN A19T MUTANT IN COMPLEX WITH IMIDAZOLE 分子名称: CHLORIDE ION, IMIDAZOLE, Peptidyl-prolyl cis-trans isomerase FKBP5, ... 著者 Fiegen, D, Draxler, S.W. 登録日 2020-01-13 公開日 2020-05-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Hybrid Screening Approach for Very Small Fragments: X-ray and Computational Screening on FKBP51. J.Med.Chem., 63, 2020
7RYW	Crystal structure of Ferritin grown by the microbatch method in the presence of Agarose 分子名称: CADMIUM ION, Ferritin light chain, SULFATE ION 著者 Aditya, S, Priyadharshine, R, Maham, I, Miller, D.J, Stojanoff, V. 登録日 2021-08-26 公開日 2022-11-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Crystal structure of Ferritin grown by microbatch method in the presence of agarose To Be Published
7RZX	Crystal Structure of Ferritin grown by microbatch method in presence of agarose and electric field 4.3KV 分子名称: CADMIUM ION, Ferritin light chain, SULFATE ION 著者 Aditya, S, Priyadharshine, R, Maham, I, Miller, J.D, Stojanoff, V. 登録日 2021-08-27 公開日 2022-11-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Crystal Structure of Ferritin grown by microbatch method in presence of agarose and electric field 4.3KV To Be Published

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