7P32
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with cyclosulfamidate 6
This is a non-PDB format compatible entry.
Summary for 7P32
| Entry DOI | 10.2210/pdb7p32/pdb |
| Related | 7P2Z |
| Descriptor | Lysosomal alpha-glucosidase, GLYCEROL, 1,2-ETHANEDIOL, ... (13 entities in total) |
| Functional Keywords | alpha-glycosidase, lysosomal, pompe disease, pharmacological chaperone, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 100880.06 |
| Authors | Roig-Zamboni, V.,Kok, K.,Overkleeft, H.,Artola, M.,Sulzenbacher, G. (deposition date: 2021-07-06, release date: 2022-07-13, Last modification date: 2024-01-31) |
| Primary citation | Kok, K.,Kuo, C.L.,Katzy, R.E.,Lelieveld, L.T.,Wu, L.,Roig-Zamboni, V.,van der Marel, G.A.,Codee, J.D.C.,Sulzenbacher, G.,Davies, G.J.,Overkleeft, H.S.,Aerts, J.M.F.G.,Artola, M. 1,6- epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal alpha-Glucosidase Stabilizer for the Treatment of Pompe Disease. J.Am.Chem.Soc., 144:14819-14827, 2022 Cited by PubMed: 35917590DOI: 10.1021/jacs.2c05666 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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