7P32
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with cyclosulfamidate 6
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AAA) | Lysosomal alpha-glucosidase | polymer | 872 | 96978.6 | 1 | UniProt (P10253) Pfam (PF00088) Pfam (PF13802) Pfam (PF01055) Pfam (PF21365) | Homo sapiens (human) | Acid maltase,Aglucosidase alfa,Myozyme |
| 2 | B (BBB) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 3 | C (BcB) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D (BfB) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 5 | E (BiB) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 6 | F (AAA) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | G (AAA) | [(1R,2R,3R,4R,5S)-2-(hydroxymethyl)-3,4,5-tris(oxidanyl)cyclohexyl]sulfamic acid | non-polymer | 257.3 | 1 | Chemie (56I) | |||
| 8 | H, I, J, K, L (AAA) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 9 | M, N, O, P, Q... (AAA) | CHLORIDE ION | non-polymer | 35.5 | 9 | Chemie (CL) | |||
| 10 | V, W, X (AAA) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 11 | AA, BA, Y, Z (AAA) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 12 | CA (AAA) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 13 | DA (AAA) | water | water | 18.0 | 680 | Chemie (HOH) |
Sequence modifications
AAA: 81 - 952 (UniProt: P10253)
| PDB | External Database | Details |
|---|---|---|
| Arg 199 | His 199 | variant |
| His 223 | Arg 223 | variant |
| Ile 780 | Val 780 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 96978.6 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1948.8 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 1952.6 | |
| All* | Total formula weight | 100880.1 |
