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6AH4
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Structure of human P2X3 receptor in complex with ATP and Ca2+ ion
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Hattori, M.
登録日2018-08-16
公開日2019-06-12
最終更新日2020-12-23
実験手法X-RAY DIFFRACTION (3.296 Å)
主引用文献Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.
Elife, 8, 2019
5MQ0
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Structure of a spliceosome remodeled for exon ligation
分子名称: 3'-EXON OF UBC4 PRE-MRNA, BOUND BY PRP22 HELICASE, 5'-EXON OF UBC4 PRE-MRNA, ...
著者Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K.
登録日2016-12-19
公開日2017-01-18
最終更新日2020-10-07
実験手法ELECTRON MICROSCOPY (4.17 Å)
主引用文献Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
8RGQ
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Open Complex I from murine liver
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
著者Vercellino, I, Sazanov, L.A.
登録日2023-12-14
公開日2024-04-24
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献SCAF1 drives the compositional diversity of mammalian respirasomes.
Nat.Struct.Mol.Biol., 31, 2024
8RGT
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Open Complex I from murine brain
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
著者Vercellino, I, Sazanov, L.A.
登録日2023-12-14
公開日2024-04-24
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献SCAF1 drives the compositional diversity of mammalian respirasomes.
Nat.Struct.Mol.Biol., 31, 2024
8RGR
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Closed Complex I from murine liver
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
著者Vercellino, I, Sazanov, L.A.
登録日2023-12-14
公開日2024-04-24
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献SCAF1 drives the compositional diversity of mammalian respirasomes.
Nat.Struct.Mol.Biol., 31, 2024
5N1Q
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METHYL-COENZYME M REDUCTASE III FROM METHANOTHERMOCOCCUS THERMOLITHOTROPHICUS AT 1.9 A RESOLUTION
分子名称: 1-THIOETHANESULFONIC ACID, Coenzyme B, FACTOR 430, ...
著者Wagner, T, Wegner, C.E, Ermler, U, Shima, S.
登録日2017-02-06
公開日2017-06-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Phylogenetic and Structural Comparisons of the Three Types of Methyl Coenzyme M Reductase from Methanococcales and Methanobacteriales.
J.Bacteriol., 199, 2017
6ECI
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BU of 6eci by Molmil
Structure of the FAD binding protein MSMEG_5243 from Mycobacterium smegmatis
分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Pyridoxamine 5'-phosphate oxidase-related, ...
著者Ahmed, F.H, Antoney, J, Carr, P.D, Jackson, C.J.
登録日2018-08-07
公開日2018-12-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress.
J. Biol. Chem., 294, 2019
5N5K
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Human catalytic MMP-12 in complex with 5-(1,2-dithiolan-3-yl)-N-(3-hydroxypropyl)pentanamide
分子名称: 5-[(3~{S})-1,2-dithiolan-3-yl]-~{N}-(3-oxidanylpropyl)pentanamide, ACETOHYDROXAMIC ACID, CALCIUM ION, ...
著者Calderone, V.
登録日2017-02-14
公開日2017-11-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).
J. Med. Chem., 60, 2017
5N86
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Crystal structure of FAS1 domain of hyaluronic acid receptor stabilin-2
分子名称: Stabilin-2
著者Twarda-Clapa, A, Labuzek, B, Grudnik, P, Dubin, G, Holak, T.A.
登録日2017-02-23
公開日2018-06-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.484 Å)
主引用文献Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2.
Acta Crystallogr D Struct Biol, 74, 2018
6B3E
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Crystal structure of human CDK12/CyclinK in complex with an inhibitor
分子名称: 1,2-ETHANEDIOL, 2-[(2S)-1-(6-{[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]amino}-9-ethyl-9H-purin-2-yl)piperidin-2-yl]ethan-1-ol, Cyclin-K, ...
著者Ferguson, A.D.
登録日2017-09-21
公開日2017-12-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Structure-Based Design of Selective Noncovalent CDK12 Inhibitors.
ChemMedChem, 13, 2018
5CFV
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BU of 5cfv by Molmil
Fusion of Maltose-binding Protein and PilA from Acinetobacter nosocomialis M2
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, MAGNESIUM ION, ...
著者Piepenbrink, K.H, Sundberg, E.J.
登録日2015-07-08
公開日2016-07-13
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Diversity in the Type IV Pili of Multidrug-resistant Acinetobacter.
J.Biol.Chem., 291, 2016
8RGP
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Closed Complex I from murine brain
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
著者Vercellino, I, Sazanov, L.A.
登録日2023-12-14
公開日2024-04-24
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献SCAF1 drives the compositional diversity of mammalian respirasomes.
Nat.Struct.Mol.Biol., 31, 2024
2J4F
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BU of 2j4f by Molmil
Torpedo acetylcholinesterase - Hg heavy-atom derivative
分子名称: ACETYLCHOLINESTERASE, MERCURY (II) ION
著者Kreimer, D.I, Dolginova, E.A, Raves, M, Sussman, J.L, Silman, I, Weiner, L.
登録日2006-08-30
公開日2006-09-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A Metastable State of Torpedo Californica Acetylcholinesterase Generated by Modification with Organomercurials
Biochemistry, 33, 1994
8K3J
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Structure of human CNTN2 immunoglobulin domains 1-6 homo-dimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-2, ...
著者Zhang, Z.Z.
登録日2023-07-16
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of human CNTN2 immunoglobulin domains 1-6 homo-dimer
To Be Published
6F6O
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BU of 6f6o by Molmil
Structure of Adenovirus 3 fiber head V239D mutant
分子名称: Fiber protein
著者Zubieta, C, Fender, P, Stermann, E, Lieber, A.
登録日2017-12-05
公開日2018-12-19
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin.
Mol Ther Methods Clin Dev, 2, 2015
4IUY
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BU of 4iuy by Molmil
Crystal structure of short-chain dehydrogenase/reductase (apo-form) from A. baumannii clinical strain WM99C
分子名称: Short chain dehydrogenase/reductase
著者Shah, B.S, Tetu, S.G, Harrop, S.J, Paulsen, I.T, Mabbutt, B.C.
登録日2013-01-21
公開日2013-03-06
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.385 Å)
主引用文献Structure of a short-chain dehydrogenase/reductase (SDR) within a genomic island from a clinical strain of Acinetobacter baumannii.
Acta Crystallogr.,Sect.F, 70, 2014
6F1T
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BU of 6f1t by Molmil
Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ...
著者Urnavicius, L, Lau, C.K, Elshenawy, M.M, Morales-Rios, E, Motz, C, Yildiz, A, Carter, A.P.
登録日2017-11-23
公開日2018-01-17
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Nature, 554, 2018
6FF7
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human Bact spliceosome core structure
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, BUD13 homolog, ...
著者Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H.
登録日2018-01-03
公開日2019-03-13
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
8RO1
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BU of 8ro1 by Molmil
Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'')
分子名称: CWF19-like protein 1 homolog, CWF19-like protein 2 homolog, Cell division cycle 5-like protein, ...
著者Vorlaender, M.K, Rothe, P, Plaschka, C.
登録日2024-01-11
公開日2024-08-07
最終更新日2024-08-21
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
8RO0
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Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS')
分子名称: Cell division cycle 5-like protein, Coiled-coil domain-containing protein 12, GCF C-terminal domain-containing protein, ...
著者Vorlaender, M.K, Rothe, P, Plaschka, C.
登録日2024-01-11
公開日2024-08-07
最終更新日2024-08-21
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
6F3A
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BU of 6f3a by Molmil
Cryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ...
著者Urnavicius, L, Lau, C.K, Elshenawy, M.M, Morales-Rios, E, Motz, C, Yildiz, A, Carter, A.P.
登録日2017-11-28
公開日2018-01-17
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (8.2 Å)
主引用文献Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Nature, 554, 2018
1XX5
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BU of 1xx5 by Molmil
Crystal Structure of Natrin from Naja atra snake venom
分子名称: ETHANOL, Natrin 1
著者Wang, J, Shen, B, Lou, X.H, Guo, M, Teng, M.K, Niu, L.W.
登録日2004-11-04
公開日2005-06-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from Naja atra venom that targets the BKCa channel
Biochemistry, 44, 2005
6EWG
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Oreochromis niloticus CEP120 second C2 domain (C2B)
分子名称: Centrosomal protein 120
著者van Breugel, M.
登録日2017-11-04
公開日2018-05-02
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis.
Cell Rep, 23, 2018
8RO2
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Integrative Structure of the human intron lariat Spliceosome (ILS'')
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, ATP-dependent RNA helicase DHX15, CWF19-like protein 1, ...
著者Rothe, P, Vorlaender, M.K, Plaschka, C.
登録日2024-01-11
公開日2024-09-18
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
6F29
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Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2-Amino-2-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.6A
分子名称: (2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, Glutamate receptor ionotropic, ...
著者Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
登録日2017-11-23
公開日2018-02-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.
J. Med. Chem., 61, 2018

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