7ZZP
 
 | | Structure of HDAC2 complexed with an inhibitory ligand | | 分子名称: | (2S)-2-HYDROXYPROPANOIC ACID, 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | | 著者 | Cleasby, A, Tisi, D. | | 登録日 | 2022-05-25 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
Acs Med.Chem.Lett., 13, 2022
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2ZWA
 | | Crystal structure of tRNA wybutosine synthesizing enzyme TYW4 | | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, Leucine carboxyl methyltransferase 2, ... | | 著者 | Suzuki, Y, Noma, A, Suzuki, T, Ishitani, R, Nureki, O. | | 登録日 | 2008-12-01 | | 公開日 | 2009-06-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.
Nucleic Acids Res., 37, 2009
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7ZZS
 | | HDAC2 complexed with an inhibitory ligand | | 分子名称: | (5~{S})-5-(4-chlorophenyl)pyrrolidin-2-one, 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, ... | | 著者 | Cleasby, A, Tisi, D. | | 登録日 | 2022-05-26 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
Acs Med.Chem.Lett., 13, 2022
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5C26
 | | Crystal structure of SYK in complex with compound 1 | | 分子名称: | 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzamide, GLU-VAL-PTR-GLU-SER-PRO, Tyrosine-protein kinase SYK | | 著者 | Han, S, Chang, J. | | 登録日 | 2015-06-15 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP).
Chemmedchem, 11, 2016
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6JZY
 | | Crystal structure of AAR with NADPH and stearyl in complex with ADO binding a long chain carbohydrate | | 分子名称: | Aldehyde decarbonylase, FE (II) ION, HEXADECAN-1-OL, ... | | 著者 | Zhang, H.M, Li, M, Gao, Y. | | 登録日 | 2019-05-04 | | 公開日 | 2020-04-01 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase.
Nat Commun, 11, 2020
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6DJ3
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6DPC
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6A9J
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5ZVR
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3KWR
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3KZX
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6MCK
 | | p97 D1D2 with CB5083 bound | | 分子名称: | 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide, Transitional endoplasmic reticulum ATPase | | 著者 | Xia, D, Tang, W.K. | | 登録日 | 2018-08-31 | | 公開日 | 2019-01-23 | | 最終更新日 | 2025-06-11 | | 実験手法 | X-RAY DIFFRACTION (3.77 Å) | | 主引用文献 | Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083.
Mol. Pharmacol., 95, 2019
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6A1D
 | | Crystal structure of a synthase 1 from Santalum album in complex with ligand | | 分子名称: | MAGNESIUM ION, SULFATE ION, Sesquisabinene B synthase 1, ... | | 著者 | Han, X, Ko, T.P, Liu, W.D, Chen, C.C, Guo, R.T. | | 登録日 | 2018-06-07 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Crystal structure of a synthase 1 from Santalum album in complex with ligand
To Be Published
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5FUB
 | | Crystal Structure of zebrafish Protein Arginine Methyltransferase 2 catalytic domain with SAH | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | | 著者 | Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J. | | 登録日 | 2016-01-22 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | | 主引用文献 | Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
FEBS J., 284, 2017
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6AGT
 | | Crystal structure of PfKRS complexed with chromone inhibitor | | 分子名称: | COBALT (II) ION, FORMIC ACID, LYSINE, ... | | 著者 | Yogavel, M, Sharma, A, Sharma, A, Baragana, B, Walpole, C. | | 登録日 | 2018-08-14 | | 公開日 | 2019-03-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | | 主引用文献 | Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6AIE
 | | Crystal structure of a new form of RsmD-like RNA methyl transferase from Mycobacterium tuberculosis determined at 1.74 A resolution | | 分子名称: | Putative methyltransferase | | 著者 | Venkataraman, S, Dhankar, A, Sinha, K.M, Manivasakan, P, Iqbal, N, Singh, T.P, Prasad, B.V.L.S. | | 登録日 | 2018-08-22 | | 公開日 | 2018-09-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Crystal structure of a new form of RsmD-like RNA methyl transferase from Mycobacterium tuberculosis determined at 1.74 A resolution
To Be Published
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3ZH5
 | | The structure of Haemophilus influenzae protein E | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, PROTEIN E | | 著者 | Singh, B, Al-Jubair, T, Riesbeck, K, Thunnissen, M.M.G.M. | | 登録日 | 2012-12-20 | | 公開日 | 2013-03-20 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | | 主引用文献 | The Unique Structure of Haemophilus Influenzae Protein E Reveals Multiple Binding Sites for Host Factors.
Infect.Immun., 81, 2013
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2YK7
 | | Structure of Neisseria LOS-specific sialyltransferase (NST), in complex with CMP-3F-Neu5Ac. | | 分子名称: | 1,2-ETHANEDIOL, CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID, ... | | 著者 | Lin, L.Y.C, Rakic, B, Chiu, C.P.C, Lameignere, E, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J. | | 登録日 | 2011-05-25 | | 公開日 | 2011-08-31 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria Meningitidis
J.Biol.Chem., 286, 2011
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1BN0
 | | SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES | | 分子名称: | SL3 RNA HAIRPIN | | 著者 | Pappalardo, L, Kerwood, D.J, Pelczer, I, Borer, P.N. | | 登録日 | 1998-07-31 | | 公開日 | 1999-04-27 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Three-dimensional folding of an RNA hairpin required for packaging HIV-1.
J.Mol.Biol., 282, 1998
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1D37
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1KFO
 | | CRYSTAL STRUCTURE OF AN RNA HELIX RECOGNIZED BY A ZINC-FINGER PROTEIN: AN 18 BASE PAIR DUPLEX AT 1.6 RESOLUTION | | 分子名称: | 5'-R(*GP*AP*AP*UP*GP*CP*CP*UP*GP*CP*GP*AP*GP*CP*AP*(5BU)P*CP*CP*C)-3' | | 著者 | Lima, S, Hildenbrand, J, Korostelev, A, Hattman, S, Li, H. | | 登録日 | 2001-11-21 | | 公開日 | 2001-12-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal structure of an RNA helix recognized by a zinc-finger protein: an 18-bp duplex at 1.6 A resolution.
RNA, 8, 2002
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5T6W
 | | HLA-B*57:01 presenting SSTRGISQLW | | 分子名称: | Beta-2-microglobulin, Decapeptide: SER-SER-THR-ARG-GLY-ILE-SER-GLN-LEU-TRP, GLYCEROL, ... | | 著者 | Pymm, P, Rossjohn, J, Vivian, J.P. | | 登録日 | 2016-09-01 | | 公開日 | 2017-03-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.
Nat. Struct. Mol. Biol., 24, 2017
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2Z6B
 | | Crystal Structure Analysis of (gp27-gp5)3 conjugated with Fe(III) protoporphyrin | | 分子名称: | 1-ETHYL-PYRROLIDINE-2,5-DIONE, Baseplate structural protein Gp27, Tail-associated lysozyme | | 著者 | Koshiyama, T, Yokoi, N, Ueno, T, Kanamaru, S, Nagano, S, Shiro, Y, Arisaka, F, Watanabe, Y. | | 登録日 | 2007-07-28 | | 公開日 | 2008-04-15 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | Molecular design of heteroprotein assemblies providing a bionanocup as a chemical reactor.
Small, 4, 2008
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7AT9
 | | Structure of protein kinase ck2 catalytic subunit (csnk2a2 gene product) in complex with the ATP-competitive inhibitor MB002 and the alphaD-pocket ligand 3,4-dichlorophenethylamine | | 分子名称: | 1,2-ETHANEDIOL, 2-(3,4-dichlorophenyl)ethanamine, 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, ... | | 著者 | Lindenblatt, D, Applegate, V, Nickelsen, A, Klussmann, M, Neundorf, I, Goetz, C, Jose, J, Niefind, K. | | 登録日 | 2020-10-29 | | 公開日 | 2021-08-04 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Molecular Plasticity of Crystalline CK2 alpha ' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity.
J.Med.Chem., 65, 2022
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4YVK
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