7AT9
Structure of protein kinase ck2 catalytic subunit (csnk2a2 gene product) in complex with the ATP-competitive inhibitor MB002 and the alphaD-pocket ligand 3,4-dichlorophenethylamine
Summary for 7AT9
Entry DOI | 10.2210/pdb7at9/pdb |
Descriptor | Casein kinase II subunit alpha', 2-(3,4-dichlorophenyl)ethanamine, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | protein kinase ck2, casein kinase 2, bivalent inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 44304.16 |
Authors | Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Goetz, C.,Jose, J.,Niefind, K. (deposition date: 2020-10-29, release date: 2021-08-04, Last modification date: 2024-06-19) |
Primary citation | Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Gotz, C.,Jose, J.,Niefind, K. Molecular Plasticity of Crystalline CK2 alpha ' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity. J.Med.Chem., 65:1302-1312, 2022 Cited by PubMed: 34323071DOI: 10.1021/acs.jmedchem.1c00063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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