6MCK
p97 D1D2 with CB5083 bound
Summary for 6MCK
Entry DOI | 10.2210/pdb6mck/pdb |
Descriptor | Transitional endoplasmic reticulum ATPase, 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide (3 entities in total) |
Functional Keywords | vcp, p97, cb-5083, aaa atpase, anticancer, drug, chaperone, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 12 |
Total formula weight | 811029.13 |
Authors | Xia, D.,Tang, W.K. (deposition date: 2018-08-31, release date: 2019-01-23, Last modification date: 2024-03-13) |
Primary citation | Tang, W.K.,Odzorig, T.,Jin, W.,Xia, D. Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083. Mol. Pharmacol., 95:286-293, 2019 Cited by PubMed: 30591537DOI: 10.1124/mol.118.114256 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.77 Å) |
Structure validation
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