6MCK

p97 D1D2 with CB5083 bound

Summary for 6MCK

• Entry DOI: 10.2210/pdb6mck/pdb
• Descriptor: Transitional endoplasmic reticulum ATPase, 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide (3 entities in total)
• Functional Keywords: vcp, p97, cb-5083, aaa atpase, anticancer, drug, chaperone, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 12
• Total formula weight: 811029.13

Authors

Xia, D.,Tang, W.K. (deposition date: 2018-08-31, release date: 2019-01-23, Last modification date: 2024-03-13)

• Primary citation: Tang, W.K.,Odzorig, T.,Jin, W.,Xia, D.; Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083.; Mol. Pharmacol., 95:286-293, 2019; PubMed: 30591537; DOI: 10.1124/mol.118.114256

Experimental method

X-RAY DIFFRACTION (3.77 Å)