PDB: 224004 件ウェブページステータス検索Chemie searchBIRD

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6OYG	Crystal structure of H62F mutant of human macrophage migration inhibitory factor 分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... 著者 Pantouris, G, Lolis, E. 登録日 2019-05-14 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020
7AV2	LTA4 hydrolase in complex with fragment1 分子名称: (4-phenoxyphenyl)methanol, ACETATE ION, IMIDAZOLE, ... 著者 Srinivas, H. 登録日 2020-11-03 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
4X8X	Crystal structure of Dscam1 isoform 1.9, N-terminal four Ig domains 分子名称: Down Syndrome cell adhesion molecule isoform 1.9, GLYCEROL, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Chen, Q. 登録日 2014-12-11 公開日 2015-12-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition Sci Adv, 2, 2016
4X9B	Crystal structure of Dscam1 isoform 4.44, N-terminal four Ig domains 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Down syndrome cell adhesion molecule, isoform 4.44, ... 著者 Chen, Q, Yu, Y, Li, S.A, Cheng, L. 登録日 2014-12-11 公開日 2015-12-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition Sci Adv, 2, 2016
6M5M	SPL-1 - GlcNAc complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, N-acetylglucosamine-specific lectin 著者 Unno, H, Hatakeyama, T. 登録日 2020-03-11 公開日 2020-06-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Novel carbohydrate-recognition mode of the invertebrate C-type lectin SPL-1 from Saxidomus purpuratus revealed by the GlcNAc-complex crystal in the presence of Ca2. Acta Crystallogr.,Sect.F, 76, 2020
6P3X	Crystal Structure of Full Length APOBEC3G E/Q (pH 7.0) 分子名称: Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ZINC ION 著者 Yang, H.J, Li, S.X, Chen, X.S. 登録日 2019-05-25 公開日 2020-02-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.402 Å) 主引用文献 Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G. Nat Commun, 11, 2020
4WX1	Structure of Aspergillus fumigatus UDP-Galactopyranose mutase mutant F66A determined from a crystal soaked with UDP-Galactopyranose 分子名称: DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GLYCEROL, SULFATE ION, ... 著者 Qureshi, I.A, Chaudhary, R. 登録日 2014-11-13 公開日 2014-12-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Contributions of Unique Active Site Residues of Eukaryotic UDP-Galactopyranose Mutases to Substrate Recognition and Active Site Dynamics. Biochemistry, 53, 2014
5EZJ	Crystal Structure of Fab of parasite invasion inhibitory antibody c1 - orthorhombic form 分子名称: Fab c12 Light chain, Fab c12 heavy chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Favuzza, P, Pluschke, G, Rudolph, M.G. 登録日 2015-11-26 公開日 2017-01-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody. Elife, 6, 2017
7Q8T	Crystal structure of NAMPT bound to ligand TSY535(compound 9a) 分子名称: Nicotinamide phosphoribosyltransferase, SULFATE ION, [(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl dihydrogen phosphate 著者 Kraemer, A, Tang, S, Butterworth, S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2021-11-11 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators. Acta Pharm Sin B, 13, 2023
4HJY	2.4 A Crystal structure of E. coli MltE-E64Q with bound chitopentaose 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endo-type membrane-bound lytic murein transglycosylase A 著者 Fibriansah, G, Gliubich, F.I, Thunnissen, A.-M.W.H. 登録日 2012-10-14 公開日 2012-10-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 On the Mechanism of Peptidoglycan Binding and Cleavage by the endo-Specific Lytic Transglycosylase MltE from Escherichia coli. Biochemistry, 51, 2012
3IW5	Human p38 MAP Kinase in Complex with an Indole Derivative 分子名称: Mitogen-activated protein kinase 14, N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Rauh, D. 登録日 2009-09-02 公開日 2009-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha J.Am.Chem.Soc., 131, 2009
6PAE	Dickeya chrysanthemi complex with L-Asp at pH 5.6 分子名称: 1,2-ETHANEDIOL, ASPARTIC ACID, GLYCEROL, ... 著者 Lubkowski, J, Wlodawer, A. 登録日 2019-06-11 公開日 2019-09-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Geometric considerations support the double-displacement catalytic mechanism of l-asparaginase. Protein Sci., 28, 2019
6P1B	Transcription antitermination factor Q21 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Q protein 著者 Yin, Z, Ebright, R.H. 登録日 2019-05-19 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.942 Å) 主引用文献 Structural basis of Q-dependent antitermination. Proc.Natl.Acad.Sci.USA, 116, 2019
4X9F	Crystal structure of Dscam1 isoform 6.9, N-terminal four Ig domains 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Down Syndrome Cell Adhesion Molecule isoform 6.9, GLYCEROL, ... 著者 Chen, Q, Yu, Y, Li, S.A, Cheng, L. 登録日 2014-12-11 公開日 2015-12-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition Sci Adv, 2, 2016
7QGJ	Apo structure of BIR2 Domain of BIRC2 分子名称: 1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 2, ZINC ION 著者 Kraemer, A, Farges, F, Schwalm, M.P, Saxena, K, Preuss, F, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2021-12-08 公開日 2022-02-09 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Apo structure BIR2 Domain of BIRC2 To Be Published
7QGP	STK10 (LOK) bound to Macrocycle CKJB51 分子名称: 1,2-ETHANEDIOL, 1-[(4-chloranyl-2-methyl-phenyl)methyl]-3-(7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.1^{2,6}.0^{17,20}]docosa-1(20),2(22),3,5,14(21),15,18-heptaen-5-yl)urea, CHLORIDE ION, ... 著者 Berger, B.-T, Schroeder, M, Kraemer, A, Schwalm, M.P, Kurz, C.G, Amrhein, J.A, Hanke, T, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2021-12-09 公開日 2022-01-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 STK10 bound to CKJB51 To Be Published
5EZO	Crystal Structure of PfCyRPA in complex with an invasion-inhibitory antibody Fab. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PfCyRPA, c12 FAB, ... 著者 Favuzza, P, Pluschke, G, Rudolph, M.G. 登録日 2015-11-26 公開日 2017-01-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.63 Å) 主引用文献 Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody. Elife, 6, 2017
7Q87	Carboxypeptidase T with (S)-3-phenyllactic acid 分子名称: ALPHA-HYDROXY-BETA-PHENYL-PROPIONIC ACID, CALCIUM ION, Carboxypeptidase T, ... 著者 Timofeev, V.I, Akparov, V.K, Shevtsov, M.B, Kuranova, I.P. 登録日 2021-11-10 公開日 2022-01-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Carboxypeptidase T with (S)-3-phenyllactic acid To Be Published
6P0U	Crystal structure of ternary DNA complex " FX(1-2)-2Xis" containing E. coli Fis and phage lambda Xis 分子名称: DNA (27-MER), FX1-2, DNA-binding protein Fis, ... 著者 Hancock, S.P, Cascio, D, Johnson, R.C. 登録日 2019-05-17 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Cooperative DNA binding by proteins through DNA shape complementarity. Nucleic Acids Res., 47, 2019
4X2T	X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the M17 Leucyl Aminopeptidase from P. falciparum 分子名称: (2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid, CARBONATE ION, M17 leucyl aminopeptidase, ... 著者 Drinkwater, N, McGowan, S. 登録日 2014-11-27 公開日 2015-02-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.729 Å) 主引用文献 X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17. Proteins, 83, 2015
6MEK	Crystal structure of Hepatitis C virus envelope glycoprotein E2 core in complex with human antibodies HEPC3 and HEPC46 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E2 GLYCOPROTEIN, ... 著者 Flyak, A.I, Bjorkman, P.J. 登録日 2018-09-06 公開日 2018-11-21 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. Cell Host Microbe, 24, 2018
8FO6	Nucleotide-free structure of a functional construct of eukaryotic elongation factor 2 kinase. 分子名称: CALCIUM ION, Calmodulin-1, Eukaryotic elongation factor 2 kinase, ... 著者 Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. 登録日 2022-12-29 公開日 2023-05-03 実験手法 X-RAY DIFFRACTION (2.553 Å) 主引用文献 ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin. Proc.Natl.Acad.Sci.USA, 120, 2023
3IET	Crystal Structure of 237mAb with antigen 分子名称: 2-acetamido-2-deoxy-alpha-D-galactopyranose, Immunoglobulin heavy chain (IgG2a), Immunoglobulin light chain (IgG2a), ... 著者 Brooks, C.L, Evans, S.V, Borisova, S.N. 登録日 2009-07-23 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Antibody recognition of a unique tumor-specific glycopeptide antigen. Proc.Natl.Acad.Sci.USA, 107, 2010
7QGM	Human CD73 (ecto 5'-nucleotidase) in complex with MRS4598 (a 3-methyl-CMPCP derivative, compound 16 in paper) in the closed state (crystal form III) 分子名称: 5'-nucleotidase, CALCIUM ION, ZINC ION, ... 著者 Strater, N. 登録日 2021-12-08 公開日 2022-02-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors. J.Med.Chem., 65, 2022
7QGL	Human CD73 (ecto 5'-nucleotidase) in complex with MRS4602 (a 3-methyl-CMPCP derivative, compound 21 in paper) in the open state 分子名称: 5'-nucleotidase, CALCIUM ION, PENTAETHYLENE GLYCOL, ... 著者 Strater, N. 登録日 2021-12-08 公開日 2022-02-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors. J.Med.Chem., 65, 2022

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