PDB: 1007 件ウェブページステータス検索Chemie searchBIRD

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1MPL	CRYSTAL STRUCTURE OF PHOSPHONATE-INHIBITED D-ALA-D-ALA PEPTIDASE REVEALS AN ANALOG OF A TETRAHEDRAL TRANSITION STATE 分子名称: D-alanyl-D-alanine carboxypeptidase, GLYCEROL, GLYCYL-L-A-AMINOPIMELYL-E-(D-2-AMINOETHYL)PHOSPHONATE 著者 Silvaggi, N.R, Anderson, J.W, Brinsmade, S.R, Pratt, R.F, Kelly, J.A. 登録日 2002-09-12 公開日 2003-02-25 最終更新日 2019-07-24 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 The Crystal Structure of Phosphonate-Inhibited d-Ala-d-Ala Peptidase Reveals an Analogue of a Tetrahedral Transition State. Biochemistry, 42, 2003
3A65	Crystal structure of 6-aminohexanoate-dimer hydrolase S112A/G181D/H266N mutant with substrate 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... 著者 Kawashima, Y, Shibata, N, Higuchi, Y, Takeo, M, Negoro, S. 登録日 2009-08-21 公開日 2010-09-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Enzymatic Synthesis of Nylon-6 Units in Organic Sol Contained Low-Water: Structural Requirement of 6-Aminohexanoate-Dimer Hydrolase for Efficient Amid Synthesis To be Published
3VWP	Crystal structure of 6-aminohexanoate-dimer hydrolase S112A/G181D/R187S/H266N/D370Y mutant complexd with 6-aminohexanoate 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... 著者 Kawashima, Y, Shibata, N, Negoro, S, Higuchi, Y. 登録日 2012-08-30 公開日 2013-10-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural, kinetic and theoretical analyses of hydrolase mutants altering in the directionality and equilibrium point of reversible amide-synthetic/hydrolytic reaction to be published
3VWN	Crystal structure of 6-aminohexanoate-dimer hydrolase G181D/R187G/H266N/D370Y mutant 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-aminohexanoate-dimer hydrolase, GLYCEROL, ... 著者 Kawashima, Y, Shibata, N, Negoro, S, Higuchi, Y. 登録日 2012-08-30 公開日 2013-10-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structural, kinetic and theoretical analyses of hydrolase mutants altering in the directionality and equilibrium point of reversible amide-synthetic/hydrolytic reaction To be Published
3A66	Crystal structure of 6-aminohexanoate-dimer hydrolase S112A/G181D/H266N/D370Y mutant with substrate 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOATE-DIMER HYDROLASE, 6-AMINOHEXANOIC ACID, ... 著者 Kawashima, Y, Shibata, N, Higuchi, Y, Takeo, M, Negoro, S. 登録日 2009-08-21 公開日 2010-09-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Enzymatic Synthesis of Nylon-6 Units in Organic Sol Contained Low-Water: Structural Requirement of 6-Aminohexanoate-Dimer Hydrolase for Efficient Amid Synthesis To be Published
3VWL	Crystal structure of 6-aminohexanoate-dimer hydrolase G181D/R187S/H266N/D370Y mutant 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-aminohexanoate-dimer hydrolase, GLYCEROL, ... 著者 Kawashima, Y, Shibata, N, Negoro, S, Higuchi, Y. 登録日 2012-08-30 公開日 2013-10-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural, kinetic and theoretical analyses of hydrolase mutants altering in the directionality and equilibrium point of reversible amide-synthetic/hydrolytic reaction To be Published
4N9K	crystal structure of beta-lactamse PenP_E166S in complex with cephaloridine 分子名称: 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Beta-lactamase 著者 Pan, X, Wong, W, Zhao, Y. 登録日 2013-10-21 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation Biochemistry, 53, 2014
4QD4	Structure of ADC-68, a Novel Carbapenem-Hydrolyzing Class C Extended-Spectrum -Lactamase from Acinetobacter baumannii 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase ADC-68, CITRIC ACID 著者 Hong, M.K, Kang, L.W. 登録日 2014-05-13 公開日 2015-01-21 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of ADC-68, a novel carbapenem-hydrolyzing class C extended-spectrum beta-lactamase isolated from Acinetobacter baumannii Acta Crystallogr.,Sect.D, 70, 2014
1PI5	Structure of N289A mutant of AmpC in complex with SM2, carboxyphenylglycylboronic acid bearing the cephalothin R1 side chain 分子名称: (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID, Beta-lactamase, PHOSPHATE ION, ... 著者 Roth, T.A, Minasov, G, Focia, P.J, Shoichet, B.K. 登録日 2003-05-29 公開日 2004-02-24 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Thermodynamic cycle analysis and inhibitor design against beta-lactamase. Biochemistry, 42, 2003
1PI4	Structure of N289A mutant of AmpC in complex with SM3, a phenylglyclboronic acid bearing the cephalothin R1 side chain 分子名称: (1R)-1-(2-THIENYLACETYLAMINO)-1-PHENYLMETHYLBORONIC ACID, Beta-lactamase, PHOSPHATE ION, ... 著者 Roth, T.A, Minasov, G, Focia, P.J, Shoichet, B.K. 登録日 2003-05-29 公開日 2004-02-24 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Thermodynamic cycle analysis and inhibitor design against beta-lactamase. Biochemistry, 42, 2003
3B3X	Crystal structure of class A beta-lactamase of Bacillus licheniformis BS3 with aminocitrate 分子名称: 2-(carboxymethyl)-D-aspartic acid, Beta-lactamase 著者 Sauvage, E, Herman, R, Kerff, F, Charlier, P. 登録日 2007-10-23 公開日 2007-11-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis Bioorg.Med.Chem.Lett., 18, 2008
3WS4	N288Q-N321Q mutant BETA-LACTAMASE DERIVED FROM CHROMOHALOBACTER SP.560 (Condition-2A) 分子名称: Beta-lactamase, CHLORIDE ION, STRONTIUM ION 著者 Arai, S, Yonezawa, Y, Okazaki, N, Matsumoto, F, Shimizu, R, Yamada, M, Adachi, M, Tamada, T, Tokunaga, H, Ishibashi, M, Tokunaga, M, Kuroki, R. 登録日 2014-02-28 公開日 2015-03-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of a highly acidic beta-lactamase from the moderate halophile Chromohalobacter sp. 560 and the discovery of a Cs(+)-selective binding site Acta Crystallogr.,Sect.D, 71, 2015
1ONH	GC1 beta-lactamase with a penem inhibitor 分子名称: 7-(5,6-DIHYDRO-8H-IMIDAZO[2,1-C][1,4]OXAZIN-2-YL)-6-FORMYL-2,7-DIHYDRO- [1,4]THIAZEPINE-3-CARBOXYLIC ACID, GLYCEROL, class C beta-lactamase 著者 Nukaga, M, Nukaga, K, Knox, J.R. 登録日 2003-02-27 公開日 2003-12-09 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Inhibition of Class A and Class C Beta-Lactamases by Penems: Crystallographic Structures of a Novel 1,4-Thiazepine Intermediate Biochemistry, 42, 2003
1PWD	Covalent acyl enzyme complex of the Streptomyces R61 DD-peptidase with cephalosporin C 分子名称: (2R)-5-(acetyloxymethyl)-2-[(1R)-1-[[(5R)-5-azanyl-6-oxidanyl-6-oxidanylidene-hexanoyl]amino]-2-oxidanylidene-ethyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, D-alanyl-D-alanine carboxypeptidase precursor 著者 Silvaggi, N.R, Josephine, H.R, Pratt, R.F, Kelly, J.A. 登録日 2003-07-01 公開日 2004-07-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin" J.Mol.Biol., 345, 2005
4OOY	Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance 分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase 著者 Lahiri, S.D, Olivier, N.B, Alm, R.A. 登録日 2014-02-04 公開日 2014-08-20 最終更新日 2018-02-14 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Avibactam and Class C beta-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance. Antimicrob.Agents Chemother., 58, 2014
3WRT	Wild type beta-lactamase DERIVED FROM CHROMOHALOBACTER SP.560 分子名称: Beta-lactamase 著者 Arai, S, Yonezawa, Y, Okazaki, N, Matsumoto, F, Shimizu, R, Yamada, M, Adachi, M, Tamada, T, Tokunaga, H, Ishibashi, M, Tokunaga, M, Kuroki, R. 登録日 2014-02-27 公開日 2015-03-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of a highly acidic beta-lactamase from the moderate halophile Chromohalobacter sp. 560 and the discovery of a Cs(+)-selective binding site Acta Crystallogr.,Sect.D, 71, 2015
2ZM2	Structure of 6-aminohexanoate-dimer hydrolase, A61V/A124V/R187S/F264C/G291R/G338A/D370Y mutant (Hyb-S4M94) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-aminohexanoate-dimer hydrolase, GLYCEROL, ... 著者 Ohki, T, Shibata, N, Higuchi, Y, Kawashima, Y, Takeo, M, Kato, D, Nego, S. 登録日 2008-04-10 公開日 2009-04-21 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Two alternative modes for optimizing nylon-6 byproduct hydrolytic activity from a carboxylesterase with a beta-lactamase fold: X-ray crystallographic analysis of directly evolved 6-aminohexanoate-dimer hydrolase. Protein Sci., 18, 2009
1PW1	Non-Covalent Complex Of Streptomyces R61 DD-Peptidase With A Highly Specific Penicillin 分子名称: (2S,5R,6R)-6-{[(6R)-6-(GLYCYLAMINO)-7-OXIDO-7-OXOHEPTANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLATE, D-alanyl-D-alanine carboxypeptidase, FORMYL GROUP, ... 著者 Silvaggi, N.R, Josephine, H.R, Pratt, R.F, Kelly, J.A. 登録日 2003-06-30 公開日 2004-07-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin" J.Mol.Biol., 345, 2005
1Q2Q	Enterobacter cloacae GC1 class C beta-lactamase complexed with penem WAY185229 分子名称: (6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID, GLYCEROL, class C beta-lactamase 著者 Nukaga, M, Venkatesan, A.M, Mansour, T.S, Hujer, A, Bonomo, R.A, Knox, J.R. 登録日 2003-07-25 公開日 2004-09-14 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates J.Med.Chem., 47, 2004
2ZM0	Structure of 6-aminohexanoate-dimer hydrolase, G181D/H266N/D370Y mutant 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-aminohexanoate-dimer hydrolase, GLYCEROL, ... 著者 Ohki, T, Shibata, N, Higuchi, Y, Kawashima, Y, Takeo, M, Kato, D, Nego, S. 登録日 2008-04-10 公開日 2009-04-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Molecular design of a nylon-6 byproduct-degrading enzyme from a carboxylesterase with a beta-lactamase fold. Febs J., 276, 2009
1PWC	penicilloyl acyl enzyme complex of the Streptomyces R61 DD-peptidase with penicillin G 分子名称: D-alanyl-D-alanine carboxypeptidase, OPEN FORM - PENICILLIN G 著者 Silvaggi, N.R, Josephine, H.R, Pratt, R.F, Kelly, J.A. 登録日 2003-07-01 公開日 2004-07-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin" J.Mol.Biol., 345, 2005
3WS2	N288Q-N321Q mutant BETA-LACTAMASE DERIVED FROM CHROMOHALOBACTER SP.560 (Condition-1C) 分子名称: Beta-lactamase, CALCIUM ION, CESIUM ION 著者 Arai, S, Yonezawa, Y, Okazaki, N, Matsumoto, F, Shimizu, R, Yamada, M, Adachi, M, Tamada, T, Tokunaga, H, Ishibashi, M, Tokunaga, M, Kuroki, R. 登録日 2014-02-27 公開日 2015-03-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of a highly acidic beta-lactamase from the moderate halophile Chromohalobacter sp. 560 and the discovery of a Cs(+)-selective binding site Acta Crystallogr.,Sect.D, 71, 2015
3W8K	Crystal structure of class C beta-lactamase Mox-1 分子名称: ACETATE ION, Beta-lactamase, ZINC ION 著者 Shimizu-ibuka, A, Oguri, T, Furuyama, T, Ishii, Y. 登録日 2013-03-15 公開日 2014-04-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of Mox-1, a unique plasmid-mediated class C beta-lactamase with hydrolytic activity towards moxalactam Antimicrob.Agents Chemother., 58, 2014
3WS1	N288Q-N321Q mutant BETA-LACTAMASE DERIVED FROM CHROMOHALOBACTER SP.560 (Condition-1B) 分子名称: Beta-lactamase, CALCIUM ION, CESIUM ION 著者 Arai, S, Yonezawa, Y, Okazaki, N, Matsumoto, F, Shimizu, R, Yamada, M, Adachi, M, Tamada, T, Tokunaga, H, Ishibashi, M, Tokunaga, M, Kuroki, R. 登録日 2014-02-27 公開日 2015-03-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of a highly acidic beta-lactamase from the moderate halophile Chromohalobacter sp. 560 and the discovery of a Cs(+)-selective binding site Acta Crystallogr.,Sect.D, 71, 2015
2ZMA	Crystal Structure of 6-Aminohexanoate-dimer Hydrolase S112A/G181D/H266N/D370Y Mutant with Substrate 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... 著者 Ohki, T, Shibata, N, Higuchi, Y, Takeo, M, Negoro, S. 登録日 2008-04-14 公開日 2009-04-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Molecular design of a nylon-6 byproduct-degrading enzyme from a carboxylesterase with a beta-lactamase fold Febs J., 276, 2009

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