PDB: 974 件ウェブページステータス検索Chemie searchBIRD

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3IWI	X-ray crystal structure of the extended-spectrum AmpC omega loop insertion (H210AAA) mutant beta-lactamase at 1.64 Angstrom resolution 分子名称: Beta-lactamase, PHOSPHATE ION 著者 Shoichet, B.K, Thomas, V.L. 登録日 2009-09-02 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3IWO	X-ray crystal structure of the extended-spectrum AmpC Y221G mutant beta-lactamase at 1.90 Angstrom resolution 分子名称: Beta-lactamase, PHOSPHATE ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose 著者 Shoichet, B.K, Thomas, V.L. 登録日 2009-09-03 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3IXG	X-ray crystal structure of the extended-spectrum AmpC T70I mutant beta-lactamase with and without benzo(b)thiophene-2-boronic acid bound at 2.14 Angstrom resolution 分子名称: BENZO[B]THIOPHENE-2-BORONIC ACID, Beta-lactamase 著者 Shoichet, B.K, Thomas, V.L. 登録日 2009-09-04 公開日 2010-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3IXH	X-ray crystal structure of the extended-spectrum AmpC Y221G mutant beta-lactamase in complex with cefotaxime at 2.3 Angstrom resolution 分子名称: Beta-lactamase, CEFOTAXIME, C3' cleaved, ... 著者 Shoichet, B.K, Thomas, V.L. 登録日 2009-09-04 公開日 2010-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3IWQ	X-ray crystal structure of the extended-spectrum AmpC E219K mutant beta-lactamase at 1.84 Angstrom resolution 分子名称: Beta-lactamase, PHOSPHATE ION 著者 Shoichet, B.K, Thomas, V.L. 登録日 2009-09-03 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3IXB	X-ray crystal structure of the extended-spectrum AmpC E219K mutant beta-lactamase complexed with benzo(b)thiophene-2-boronic acid (BZB) at 1.63 Angstrom resolution 分子名称: BENZO[B]THIOPHENE-2-BORONIC ACID, Beta-lactamase, PHOSPHATE ION 著者 Shoichet, B.K, Thomas, V.L. 登録日 2009-09-03 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3IXD	X-ray crystal structure of the extended-spectrum AmpC V298E mutant beta-lactamase at 2.64 Angstrom resolution 分子名称: Beta-lactamase, SULFATE ION 著者 Shoichet, B.K, Thomas, V.L. 登録日 2009-09-03 公開日 2010-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3LY4	Crystal Structure of fluorophore-labeled Class A -lactamase PenP-E166Cb in complex with penicillin G 分子名称: Beta-lactamase, OPEN FORM - PENICILLIN G 著者 Zhao, Y.X, Leung, Y.C, Wong, W.T. 登録日 2010-02-26 公開日 2011-03-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of fluorophore-labeled Class A -lactamase PenP-E166Cb in complex with penicillin G To be Published
3LY3	Crystal Structure of fluorophore-labeled Class A Beta-lactamase PenP 分子名称: Beta-lactamase 著者 Zhao, Y.X, Leung, Y.C, Wong, W.T. 登録日 2010-02-26 公開日 2011-03-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of fluorophore-labeled Class A Beta-lactamase PenP To be Published
3M2K	Crystal Structure of fluorescein-labeled Class A -beta lactamase PenP in complex with cefotaxime 分子名称: Beta-lactamase, CEFOTAXIME, C3' cleaved, ... 著者 Zhao, Y.X, Leung, Y.C, Wong, W.T. 登録日 2010-03-07 公開日 2011-03-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural studies of the mechanism for biosensing antibiotics in a fluorescein-labeled beta-lactamase. BMC Struct. Biol., 11, 2011
3M2J	Crystal Structure of fluorescein-labeled Class A -lactamase PenP 分子名称: 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, Beta-lactamase, SULFATE ION 著者 Zhao, Y.X, Leung, Y.C, Wong, W.T. 登録日 2010-03-07 公開日 2011-03-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of fluorescein-labeled Class A -lactamase PenP To be Published
3BLS	AMPC BETA-LACTAMASE FROM ESCHERICHIA COLI 分子名称: AMPC BETA-LACTAMASE, M-AMINOPHENYLBORONIC ACID 著者 Usher, K.C, Shoichet, B.K, Remington, S.J. 登録日 1998-06-04 公開日 1998-08-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design. Biochemistry, 37, 1998
3BM6	AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid 分子名称: 4-(dihydroxyboranyl)-2-({[4-(phenylsulfonyl)thiophen-2-yl]sulfonyl}amino)benzoic acid, Beta-lactamase 著者 Tondi, D. 登録日 2007-12-12 公開日 2009-02-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
4BLM	BETA-LACTAMASE OF BACILLUS LICHENIFORMIS 749(SLASH)C. REFINEMENT AT 2 ANGSTROMS RESOLUTION AND ANALYSIS OF HYDRATION 分子名称: BETA-LACTAMASE, SULFATE ION 著者 Knox, J.R, Moews, P.C. 登録日 1991-05-28 公開日 1993-01-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Beta-lactamase of Bacillus licheniformis 749/C. Refinement at 2 A resolution and analysis of hydration. J.Mol.Biol., 220, 1991
4E3J	Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl benzene sulfonamide boronic acid inhibitor 分子名称: Beta-lactamase, PHOSPHATE ION, [({[4-(1H-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid 著者 Eidam, O, Shoichet, B.K. 登録日 2012-03-09 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7999 Å) 主引用文献 Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012
4E3O	Crystal structure of AmpC beta-lactamase in complex with a small chloromethyl sulfonamide boronic acid inhibitor 分子名称: ({[(chloromethyl)sulfonyl]amino}methyl)boronic acid, Beta-lactamase, PHOSPHATE ION 著者 Eidam, O, Shoichet, B.K. 登録日 2012-03-09 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012
4E3M	Crystal structure of AmpC beta-lactamase in complex with a 2-chloro-4-tetrazolyl benzene sulfonamide boronic acid inhibitor 分子名称: Beta-lactamase, PHOSPHATE ION, [({[2-chloro-4-(1H-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid 著者 Eidam, O, Shoichet, B.K. 登録日 2012-03-09 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012
4E3I	Crystal structure of AmpC beta-lactamase in complex with a designed 3-carboxyl benzyl sulfonamide boronic acid inhibitor 分子名称: 3-({[(dihydroxyboranyl)methyl]sulfamoyl}methyl)benzoic acid, Beta-lactamase, PHOSPHATE ION 著者 Eidam, O, Shoichet, B.K. 登録日 2012-03-09 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012
4E3L	Crystal structure of AmpC beta-lactamase in complex with a 3-chloro-4-tetrazolyl benzene sulfonamide boronic acid inhibitor 分子名称: Beta-lactamase, PHOSPHATE ION, [({[3-chloro-4-(1H-tetrazol-5-yl)phenyl]sulfonyl}amino)methyl]boronic acid 著者 Eidam, O, Shoichet, B.K. 登録日 2012-03-09 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012
4E3K	Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl pyridine sulfonamide boronic acid inhibitor 分子名称: Beta-lactamase, PHOSPHATE ION, [({[6-(1H-tetrazol-5-yl)pyridin-3-yl]sulfonyl}amino)methyl]boronic acid 著者 Eidam, O, Shoichet, B.K. 登録日 2012-03-09 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.4299 Å) 主引用文献 Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012
4E3N	Crystal structure of AmpC beta-lactamase in complex with a 2-trifluoromethyl-4-tetrazolyl benzene sulfonamide boronic acid inhibitor 分子名称: Beta-lactamase, PHOSPHATE ION, [({[4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)methyl]boronic acid 著者 Eidam, O, Shoichet, B.K. 登録日 2012-03-09 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109, 2012
4E6X	ClbP in complex boron-based inhibitor 分子名称: ({[(chloromethyl)sulfonyl]amino}methyl)boronic acid, ClbP peptidase, PHOSPHATE ION 著者 Cougnoux, A, Delmas, J, Bonnet, R. 登録日 2012-03-16 公開日 2013-03-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 The NRP peptidase ClbP as a target for the inhibition of genotoxicity, cell proliferation and tumorogenesis mediated by pks-harboring bacteria To be Published
3FKW	AmpC K67R mutant apo structure 分子名称: Beta-lactamase, PHOSPHATE ION, POTASSIUM ION 著者 Chen, Y, McReynolds, A, Shoichet, B.K. 登録日 2008-12-17 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.498 Å) 主引用文献 Re-examining the role of Lys67 in class C beta-lactamase catalysis. Protein Sci., 18, 2009
4E6W	ClbP in complex with 3-aminophenyl boronic acid 分子名称: ClbP peptidase, M-AMINOPHENYLBORONIC ACID, PHOSPHATE ION 著者 Cougnoux, A, Delmas, J, Bonnet, R. 登録日 2012-03-16 公開日 2013-03-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 The NRP peptidase ClbP as a target for the inhibition of genotoxicity, cell proliferation and tumorogenesis mediated by pks-harboring bacteria To be Published
3FKV	AmpC K67R mutant complexed with benzo(b)thiophene-2-boronic acid (bzb) 分子名称: BENZO[B]THIOPHENE-2-BORONIC ACID, Beta-lactamase, PHOSPHATE ION, ... 著者 Chen, Y, McReynolds, A, Shoichet, B.K. 登録日 2008-12-17 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.847 Å) 主引用文献 Re-examining the role of Lys67 in class C beta-lactamase catalysis. Protein Sci., 18, 2009

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