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PDB: 19 件
8Q6F
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BU of 8q6f by Molmil
HUMAN PI4KIIIB IN COMPLEX WITH COVALENTLY BOUND INHIBITOR (COMPOUND 4)
分子名称: 1,2-ETHANEDIOL, 3-(3-fluorosulfonyloxy-4-methoxy-phenyl)-2,5-dimethyl-7-(pyridin-4-ylmethylamino)pyrazolo[1,5-a]pyrimidine, GLYCEROL, ...
著者Somers, D.O.
登録日2023-08-11
公開日2023-12-13
実験手法X-RAY DIFFRACTION (1.506 Å)
主引用文献Covalent targeting of non-cysteine residues in PI4KIII beta.
Rsc Chem Biol, 4, 2023
8Q6G
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BU of 8q6g by Molmil
HUMAN PI4KIIIB IN COMPLEX WITH COVALENTLY BOUND INHIBITOR (COMPOUND 8)
分子名称: 1,2-ETHANEDIOL, 3-(3,4-dimethoxyphenyl)-7-[(4-fluorosulfonyloxyphenyl)methylamino]-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine, MAGNESIUM ION, ...
著者Somers, D.O.
登録日2023-08-11
公開日2023-12-13
実験手法X-RAY DIFFRACTION (1.541 Å)
主引用文献Covalent targeting of non-cysteine residues in PI4KIII beta.
Rsc Chem Biol, 4, 2023
8Q6H
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BU of 8q6h by Molmil
HUMAN PI4KIIIB IN COMPLEX WITH COVALENTLY BOUND INHIBITOR (COMPOUND 11)
分子名称: 1,2-ETHANEDIOL, 3-(3-fluorosulfonyloxy-4-methoxy-phenyl)-7-[(4-fluorosulfonyloxyphenyl)methylamino]-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine, MAGNESIUM ION, ...
著者Somers, D.O.
登録日2023-08-11
公開日2023-12-13
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Covalent targeting of non-cysteine residues in PI4KIII beta.
Rsc Chem Biol, 4, 2023
5NAS
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BU of 5nas by Molmil
Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide
分子名称: 14-3-3 protein zeta/delta, Phosphatidylinositol 4-kinase beta
著者Boura, E, Eisenreichova, A.
登録日2017-02-28
公開日2017-03-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide
To Be Published
5LX2
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BU of 5lx2 by Molmil
Lt 14-3-3 in complex with PI4KIIIB peptide
分子名称: KLTH0G14146p, Phosphatidylinositol 4-kinase beta
著者Boura, E, Eisenreichova, A.
登録日2016-09-19
公開日2016-11-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.579 Å)
主引用文献Lt 14-3-3 in complex with PI4KIIIB peptide
To Be Published
5C46
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BU of 5c46 by Molmil
Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta in complex with GTP gamma S loaded Rab11
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Phosphatidylinositol 4-kinase beta, ...
著者Burke, J.E, Fowler, M.L.
登録日2015-06-17
公開日2016-01-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11.
Protein Sci., 25, 2016
6GL3
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BU of 6gl3 by Molmil
Crystal structure of human Phosphatidylinositol 4-kinase III beta (PI4KIIIbeta) in complex with ligand 44
分子名称: (3~{S})-4-(6-azanyl-1-methyl-pyrazolo[3,4-d]pyrimidin-4-yl)-~{N}-(4-methoxy-2-methyl-phenyl)-3-methyl-piperazine-1-carboxamide, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta
著者Lammens, A, Augustin, M, Steinbacher, S, Reuberson, J.
登録日2018-05-22
公開日2018-08-15
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Discovery of a Potent, Orally Bioavailable PI4KIII beta Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.
J. Med. Chem., 61, 2018
4D0L
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BU of 4d0l by Molmil
Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ...
著者Burke, J.E, Inglis, A.J, Perisic, O, Masson, G.R, McLaughin, S.H, Rutaganira, F, Shokat, K.M, Williams, R.L.
登録日2014-04-29
公開日2014-05-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.
Science, 344, 2014
5EUQ
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BU of 5euq by Molmil
Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11
分子名称: GUANOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
著者Burke, J.E, Fowler, M.L.
登録日2015-11-19
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III beta.
J.Med.Chem., 59, 2016
5C4G
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BU of 5c4g by Molmil
Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with the inhibitor BQR695 in complex with GDP loaded Rab11
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, N~2~-[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]-N-methylglycinamide, ...
著者Burke, J.E, Fowler, M.L.
登録日2015-06-18
公開日2016-01-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11.
Protein Sci., 25, 2016
5FBR
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BU of 5fbr by Molmil
PI4KB in complex with Rab11 and the MI359 Inhibitor
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
著者Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
登録日2015-12-14
公開日2016-12-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.28 Å)
主引用文献PI4KB in complex with Rab11 and the MI359 Inhibitor
To Be Published
5FBV
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BU of 5fbv by Molmil
PI4KB in complex with Rab11 and the MI364 Inhibitor
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
著者Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
登録日2015-12-14
公開日2016-12-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.285 Å)
主引用文献PI4KB in complex with Rab11 and the MI364 Inhibitor
To Be Published
4WAE
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BU of 4wae by Molmil
Phosphatidylinositol 4-kinase III beta crystallized with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta
著者Chalupska, D, Boura, E.
登録日2014-08-29
公開日2015-05-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.318 Å)
主引用文献Highly Selective Phosphatidylinositol 4-Kinase III beta Inhibitors and Structural Insight into Their Mode of Action.
J.Med.Chem., 58, 2015
5FBL
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BU of 5fbl by Molmil
PI4KB in complex with Rab11 and the MI356 Inhibitor
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
著者Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
登録日2015-12-14
公開日2016-12-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.372 Å)
主引用文献PI4KB in complex with Rab11 and the MI356 Inhibitor
To Be Published
4WAG
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BU of 4wag by Molmil
Phosphatidylinositol 4-kinase III beta crystallized with MI103 inhibitor
分子名称: 6-chloro-3-(3,4-dimethoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-amine, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta
著者Chalupska, D, Boura, E.
登録日2014-08-29
公開日2015-05-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.407 Å)
主引用文献Highly Selective Phosphatidylinositol 4-Kinase III beta Inhibitors and Structural Insight into Their Mode of Action.
J.Med.Chem., 58, 2015
5FBW
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BU of 5fbw by Molmil
PI4KB in complex with Rab11 and the MI369 Inhibitor
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
著者Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
登録日2015-12-14
公開日2016-12-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.487 Å)
主引用文献PI4KB in complex with Rab11 and the MI369 Inhibitor
To Be Published
5FBQ
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BU of 5fbq by Molmil
PI4KB in complex with Rab11 and the MI358 Inhibitor
分子名称: GUANOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
著者Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
登録日2015-12-14
公開日2016-12-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.789 Å)
主引用文献PI4KB in complex with Rab11 and the MI358 Inhibitor
To Be Published
4D0M
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BU of 4d0m by Molmil
Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ...
著者Burke, J.E, Inglis, A.J, Perisic, O, Masson, G.R, McLaughlin, S.H, Rutaganira, F, Shokat, K.M, Williams, R.L.
登録日2014-04-29
公開日2014-05-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (6 Å)
主引用文献Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.
Science, 344, 2014
2N73
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BU of 2n73 by Molmil
Solution structure of the ACBD3:PI4KB complex
分子名称: Golgi resident protein GCP60, Phosphatidylinositol 4-kinase beta
著者Veverka, V, Hexnerova, R.
登録日2015-09-02
公開日2016-07-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein.
Sci Rep, 6, 2016

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件を2024-07-10に公開中

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