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PDB: 14 件
6HEI
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BU of 6hei by Molmil
Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA
分子名称: 1,2-ETHANEDIOL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28
著者Gersch, M, Komander, D.
登録日2018-08-20
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
7TUO
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BU of 7tuo by Molmil
Crystal structure analysis of human USP28 complex with a compound
分子名称: 7-amino-N-(2-{4-[(1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl]phenyl}ethyl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28
著者Seo, H.-S, Dhe-Paganon, S.
登録日2022-02-03
公開日2023-02-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Crystal Structure Analysis of human USP28 complex with a compound
To Be Published
6HEH
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BU of 6heh by Molmil
Structure of the catalytic domain of USP28 (insertion deleted)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28
著者Gersch, M, Komander, D.
登録日2018-08-20
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
8P19
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BU of 8p19 by Molmil
USP28 USP domain apo
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28
著者Sauer, F, Karal Nair, R, Kisker, C.
登録日2023-05-11
公開日2024-05-22
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献USP28 USP domain apo
To Be Published
8P14
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BU of 8p14 by Molmil
USP28 USP domain in complex with Vismodegib
分子名称: 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28
著者Sauer, F, Karal Nair, R, Kisker, C.
登録日2023-05-11
公開日2024-05-22
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献USP28 USP domain in complex with Vismodegib
To Be Published
8P1P
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BU of 8p1p by Molmil
USP28 in complex with AZ1
分子名称: 2-[[5-bromanyl-2-[[4-fluoranyl-3-(trifluoromethyl)phenyl]methoxy]phenyl]methylamino]ethanol, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Sauer, F, Karal-Nair, R, Kisker, C.
登録日2023-05-12
公開日2024-05-22
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献USP28 in complex with AZ1
To Be Published
6HEJ
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BU of 6hej by Molmil
Structure of human USP28
分子名称: SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28
著者Gersch, M, Komander, D.
登録日2018-08-20
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
8P1Q
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BU of 8p1q by Molmil
USP28 in complex with FT206
分子名称: 3-azanyl-N-[(2S)-6-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-1,2,3,4-tetrahydronaphthalen-2-yl]-6-methyl-thieno[2,3-b]pyridine-2-carboxamide, DIMETHYL SULFOXIDE, Ubiquitin carboxyl-terminal hydrolase 28
著者Sauer, F, Karal Nair, R, Kisker, C.
登録日2023-05-12
公開日2024-05-22
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献USP28 in complex with FT206
To Be Published
8HJE
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BU of 8hje by Molmil
Vismodegib binds to the catalytical domain of human Ubiquitin-Specific Protease 28
分子名称: 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, Ubiquitin carboxyl-terminal hydrolase 28
著者Shi, L, Wang, H, Xu, Z, Xiong, B, Zhang, N.
登録日2022-11-23
公開日2023-05-03
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structure-based discovery of potent USP28 inhibitors derived from Vismodegib.
Eur.J.Med.Chem., 254, 2023
6HEK
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BU of 6hek by Molmil
Structure of human USP28 bound to Ubiquitin-PA
分子名称: CHLORIDE ION, Polyubiquitin-B, TETRAETHYLENE GLYCOL, ...
著者Gersch, M, Komander, D.
登録日2018-08-20
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6H4I
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BU of 6h4i by Molmil
Usp28 catalytic domain apo
分子名称: SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28
著者Klemm, T.A, Sauer, F, Kisker, C.
登録日2018-07-21
公開日2019-03-27
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities.
Mol.Cell, 74, 2019
6H4H
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BU of 6h4h by Molmil
Usp28 catalytic domain variant E593D in complex with UbPA
分子名称: Polyubiquitin-B, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28, ...
著者Klemm, T.A, Sauer, F, Kisker, C.
登録日2018-07-21
公開日2019-03-27
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities.
Mol.Cell, 74, 2019
2LVA
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BU of 2lva by Molmil
NMR solution structure of the N-terminal domain of human USP28, Northeast structural genomics consortium target HT8470A
分子名称: Ubiquitin carboxyl-terminal hydrolase 28
著者Lemak, A, Yee, A, Houliston, S, Garcia, M, Dhe-Paganon, S, Montelione, G.T, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)
登録日2012-06-29
公開日2012-07-18
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR solution structure of the N-terminal domain of human USP28
To be Published
2MUU
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BU of 2muu by Molmil
The Proteolytic Activity of Ubiquitin-specific Protease 28 Is Modulated by the N-terminal Domain
分子名称: Ubiquitin carboxyl-terminal hydrolase 28
著者Wen, Y, Shi, L, Zhang, N.
登録日2014-09-17
公開日2016-04-20
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights.
Biochem.J., 471, 2015

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件を2024-06-26に公開中

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