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PDB: 29 件
6VH6
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Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragment
分子名称: 4-hydroxy-6-methyl-2H-1-benzopyran-2-one, Epstein-Barr nuclear antigen 1
著者Messick, T.E, Lieberman, P.M.
登録日2020-01-09
公開日2020-05-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Biophysical Screens Identify Fragments That Bind to the Viral DNA-Binding Proteins EBNA1 and LANA.
Molecules, 25, 2020
6NPP
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Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragments
分子名称: 3-(phenylethynyl)-2-(1H-pyrrol-1-yl)benzoic acid, EBNA1, Epstein-Barr nuclear antigen 1
著者Messick, T.E.
登録日2019-01-18
公開日2019-03-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
Sci Transl Med, 11, 2019
2FYY
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BU of 2fyy by Molmil
The role of T cell receptor alpha genes in directing human MHC restriction
分子名称: 11-mer peptide from Epstein-Barr nuclear antigen 1, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Miles, J.J, Borg, N.A.
登録日2006-02-08
公開日2006-12-26
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope.
J Immunol., 177, 2006
6NPI
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BU of 6npi by Molmil
Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragments
分子名称: ({2-[(4-bromo-5-methyl-1,2-oxazol-3-yl)amino]-2-oxoethyl}sulfanyl)acetic acid, 2-pyrrol-1-ylbenzoic acid, Epstein-Barr nuclear antigen 1
著者Messick, T.E.
登録日2019-01-17
公開日2019-03-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.501 Å)
主引用文献Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
Sci Transl Med, 11, 2019
6NPM
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BU of 6npm by Molmil
Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragments
分子名称: 5-(phenylethynyl)pyridine-3-carboxylic acid, Epstein-Barr nuclear antigen 1
著者Messick, T.E.
登録日2019-01-17
公開日2019-03-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.603 Å)
主引用文献Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
Sci Transl Med, 11, 2019
4PRE
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BU of 4pre by Molmil
Crystal structure of a HLA-B*35:08-HPVG-Q5
分子名称: Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, MHC class I antigen
著者Yu Chih, L, Rossjohn, J, Gras, S.
登録日2014-03-05
公開日2014-04-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism.
J.Biol.Chem., 289, 2014
1YY6
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BU of 1yy6 by Molmil
The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with an EBNA1 peptide
分子名称: Epstein-Barr nuclear antigen-1, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 7
著者Saridakis, V, Sheng, Y, Sarkari, F, Holowaty, M, Shire, K, Nguyen, T, Zhang, R, Liao, J, Lee, W, Edwards, A.M, Arrowsmith, C.H, Frappier, L.
登録日2005-02-23
公開日2005-04-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
Mol.Cell, 18, 2005
4PRD
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BU of 4prd by Molmil
Crystal structure of a HLA-B*35:08-HPVG-D5
分子名称: ACETATE ION, Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, ...
著者Yu Chih, L, Rossjohn, J, Gras, S.
登録日2014-03-05
公開日2014-04-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism.
J.Biol.Chem., 289, 2014
4PR5
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Crystal structure of a HLA-B*35:01-HPVG-D5
分子名称: Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, HLA class I histocompatibility antigen, ...
著者Yu Chih, L, Rossjohn, J, Gras, S.
登録日2014-03-05
公開日2014-04-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism.
J.Biol.Chem., 289, 2014
4PRA
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BU of 4pra by Molmil
Crystal structure of a HLA-B*35:01-HPVG-Q5
分子名称: Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, MHC class I antigen
著者Yu Chih, L, Rossjohn, J, Gras, S.
登録日2014-03-05
公開日2014-04-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism.
J.Biol.Chem., 289, 2014
2FZ3
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BU of 2fz3 by Molmil
The role of T cell receptor alpha genes in directing human MHC restriction
分子名称: 11-mer peptide from Epstein-Barr nuclear antigen 1, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Miles, J.J, Borg, N.A.
登録日2006-02-09
公開日2006-12-26
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope.
J Immunol., 177, 2006
5WMF
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BU of 5wmf by Molmil
Crystal structure of the Hexameric Ring of Epstein-Barr Virus Nuclear Antigen-1, EBNA1
分子名称: Epstein-Barr nuclear antigen 1
著者Messick, T.E.
登録日2017-07-28
公開日2017-08-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance.
J. Virol., 91, 2017
5WUM
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BU of 5wum by Molmil
Crystal structure of mouse importin-alpha1 bound to S385-phosphorylated NLS of EBNA1
分子名称: Epstein-Barr nuclear antigen 1, Importin subunit alpha-1
著者Nakada, R, Hirano, H, Matsuura, Y.
登録日2016-12-19
公開日2017-01-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal.
Biochem. Biophys. Res. Commun., 484, 2017
3MV7
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BU of 3mv7 by Molmil
Crystal Structure of the TK3 TCR in complex with HLA-B*3501/HPVG
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-35 alpha chain, ...
著者Gras, S, Chen, Z, Miles, J.J, Liu, Y.C, Bell, M.J, Sullivan, L.C, Kjer-Nielsen, L, Brennan, R.M, Burrows, J.M, Neller, M.A, Khanna, R, Purcell, A.W, Brooks, A.G, McCluskey, J, Rossjohn, J, Burrows, S.R.
登録日2010-05-03
公開日2010-06-09
最終更新日2011-07-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Allelic polymorphism in the T cell receptor and its impact on immune responses
J.Exp.Med., 207, 2010
3MV8
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BU of 3mv8 by Molmil
Crystal Structure of the TK3-Gln55His TCR in complex with HLA-B*3501/HPVG
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-35 alpha chain, ...
著者Gras, S, Chen, Z, Miles, J.J, Liu, Y.C, Bell, M.J, Sullivan, L.C, Kjer-Nielsen, L, Brennan, R.M, Burrows, J.M, Neller, M.A, Khanna, R, Purcell, A.W, Brooks, A.G, McCluskey, J, Rossjohn, J, Burrows, S.R.
登録日2010-05-03
公開日2010-06-09
最終更新日2011-07-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Allelic polymorphism in the T cell receptor and its impact on immune responses
J.Exp.Med., 207, 2010
7KE3
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BU of 7ke3 by Molmil
Heavy chain ferritin with C-terminal EBNA1 epitope
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FE (III) ION, Ferritin heavy chain,Epstein-Barr nuclear antigen 1
著者Pederick, J.L, Bruning, J.B.
登録日2020-10-10
公開日2021-09-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Immunogenicity study of engineered ferritins with C- and N-terminus insertion of Epstein-Barr nuclear antigen 1 epitope.
Vaccine, 39, 2021
5WUN
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BU of 5wun by Molmil
Crystal structure of mouse importin-alpha1 bound to non-phosphorylated NLS of EBNA1
分子名称: Epstein-Barr nuclear antigen 1, Importin subunit alpha-1
著者Nakada, R, Hirano, H, Matsuura, Y.
登録日2016-12-19
公開日2017-01-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal.
Biochem. Biophys. Res. Commun., 484, 2017
1B3T
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BU of 1b3t by Molmil
EBNA-1 NUCLEAR PROTEIN/DNA COMPLEX
分子名称: DNA (5'-D(*GP*GP*GP*AP*AP*GP*CP*AP*TP*AP*TP*GP*CP*TP*TP*CP*CP*C)-3'), PROTEIN (NUCLEAR PROTEIN EBNA1)
著者Bochkarev, A, Bochkareva, E, Edwards, A, Frappier, L.
登録日1998-12-14
公開日1998-12-15
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The 2.2 A structure of a permanganate-sensitive DNA site bound by the Epstein-Barr virus origin binding protein, EBNA1.
J.Mol.Biol., 284, 1998
5T7X
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BU of 5t7x by Molmil
Crystal structure of HHV-4 EBNA1 DNA binding domain (patient-derived, nasopharyngeal carcinoma) bound to DNA
分子名称: DNA (5'-D(*GP*GP*AP*TP*AP*GP*CP*CP*TP*AP*TP*GP*CP*TP*AP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*TP*AP*GP*CP*AP*TP*AP*GP*GP*CP*TP*AP*TP*CP*C)-3'), Epstein-Barr nuclear antigen 1
著者Malecka, K.A, Messick, T.E, Lieberman, P.M.
登録日2016-09-06
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.
Oncotarget, 8, 2017
4PRI
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BU of 4pri by Molmil
Crystal structure of TK3 TCR-HLA-B*35:08-HPVG complex
分子名称: Beta-2-microglobulin, CHLORIDE ION, Epstein-Barr nuclear antigen 1, ...
著者Yu Chih, L, Rossjohn, J, Gras, S.
登録日2014-03-05
公開日2014-04-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism.
J.Biol.Chem., 289, 2014
7K7R
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BU of 7k7r by Molmil
EBNA1 peptide AA386-405 with Fab MS39p2w174
分子名称: CHLORIDE ION, EBNA1 peptide AA386-405, Fab HC MS39p2w174, ...
著者Lanz, T.V, Robinson, W.H, Jude, K.M.
登録日2020-09-23
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM.
Nature, 603, 2022
4PRP
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BU of 4prp by Molmil
Crystal structure of TK3 TCR-HLA-B*35:01-HPVG-Q5 complex
分子名称: Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, MHC class I antigen, ...
著者Yu Chih, L, Rossjohn, J, Gras, S.
登録日2014-03-06
公開日2014-04-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism.
J.Biol.Chem., 289, 2014
4PRH
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BU of 4prh by Molmil
Crystal structure of TK3 TCR-HLA-B*35:08-HPVG-D5 complex
分子名称: Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, MHC class I antigen, ...
著者Yu Chih, L, Rossjohn, J, Gras, S.
登録日2014-03-05
公開日2014-04-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism.
J.Biol.Chem., 289, 2014
1VHI
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EPSTEIN BARR VIRUS NUCLEAR ANTIGEN-1 DNA-BINDING DOMAIN, RESIDUES 470-607
分子名称: EPSTEIN BARR VIRUS NUCLEAR ANTIGEN-1
著者Bochkarev, A, Barwell, J, Pfuetzner, R, Furey, W, Edwards, A, Frappier, L.
登録日1996-10-05
公開日1996-12-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1.
Cell(Cambridge,Mass.), 83, 1995
3MV9
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Crystal Structure of the TK3-Gln55Ala TCR in complex with HLA-B*3501/HPVG
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-35 alpha chain, ...
著者Gras, S, Chen, Z, Miles, J.J, Liu, Y.C, Bell, M.J, Sullivan, L.C, Kjer-Nielsen, L, Brennan, R.M, Burrows, J.M, Neller, M.A, Khanna, R, Purcell, A.W, Brooks, A.G, McCluskey, J, Rossjohn, J, Burrows, S.R.
登録日2010-05-03
公開日2010-06-09
最終更新日2011-07-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Allelic polymorphism in the T cell receptor and its impact on immune responses
J.Exp.Med., 207, 2010

 

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