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PDB: 33 件
2ZEM
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BU of 2zem by Molmil
Crystal structure of the human glutaminyl cyclase mutant D248Q at 2.18 angstrom resolution
分子名称: Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION
著者Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H.
登録日2007-12-13
公開日2008-04-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
7CM0
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BU of 7cm0 by Molmil
Crystal structure of a glutaminyl cyclase in complex with NHV-1009
分子名称: 1-(cyclopentylmethyl)-1-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]urea, Glutaminyl-peptide cyclotransferase, ZINC ION
著者Lee, J.W, Song, J.Y, Jang, T.H, Ha, J.H.
登録日2020-07-23
公開日2021-12-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Eur.J.Med.Chem., 226, 2021
2AFS
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BU of 2afs by Molmil
Crystal structure of the genetic mutant R54W of human glutaminyl cyclase
分子名称: Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION
著者Huang, K.F, Liu, Y.L, Cheng, W.J, Ko, T.P, Wang, A.H.J.
登録日2005-07-26
公開日2005-08-23
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation
Proc.Natl.Acad.Sci.Usa, 102, 2005
2AFU
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BU of 2afu by Molmil
Crystal structure of human glutaminyl cyclase in complex with glutamine t-butyl ester
分子名称: Glutaminyl-peptide cyclotransferase, TERT-BUTYL D-ALPHA-GLUTAMINATE, ZINC ION
著者Huang, K.F, Liu, Y.L, Cheng, W.J, Ko, T.P, Wang, A.H.J.
登録日2005-07-26
公開日2005-08-23
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation
Proc.Natl.Acad.Sci.Usa, 102, 2005
2AFO
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BU of 2afo by Molmil
Crystal structure of human glutaminyl cyclase at pH 8.0
分子名称: Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION
著者Huang, K.F, Liu, Y.L, Cheng, W.J, Ko, T.P, Wang, A.H.J.
登録日2005-07-26
公開日2005-08-23
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation
Proc.Natl.Acad.Sci.Usa, 102, 2005
8XGY
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BU of 8xgy by Molmil
Crystal structure of human Golgi resident glutaminyl cyclase in complex with (R,Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((1-acetylpyrrolidin-3-yl)oxy)indolin-2-one
分子名称: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-[(3~{R})-1-ethanoylpyrrolidin-3-yl]oxy-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
著者Li, G.-B, Wang, X.-Y.
登録日2023-12-16
公開日2024-06-12
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XGT
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Crystal structure of human secretory glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-hydroxyindolin-2-one
分子名称: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-oxidanyl-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
著者Li, G.-B, Wang, X.-Y.
登録日2023-12-15
公開日2024-06-12
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (2.813 Å)
主引用文献X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XGB
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BU of 8xgb by Molmil
Crystal structure of human secretory glutaminyl cyclase in complex with (S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one
分子名称: (5~{S})-1-(3~{H}-benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
著者Li, G.-B, Wang, X.-Y.
登録日2023-12-15
公開日2024-06-12
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
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