2AFU
Crystal structure of human glutaminyl cyclase in complex with glutamine t-butyl ester
Summary for 2AFU
Entry DOI | 10.2210/pdb2afu/pdb |
Related | 2AFO 2AFS 2AFW 2AFX 2AFZ |
Descriptor | Glutaminyl-peptide cyclotransferase, ZINC ION, TERT-BUTYL D-ALPHA-GLUTAMINATE, ... (4 entities in total) |
Functional Keywords | alpha-beta protein, metalloprotein, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: Q16769 |
Total number of polymer chains | 2 |
Total formula weight | 75648.15 |
Authors | Huang, K.F.,Liu, Y.L.,Cheng, W.J.,Ko, T.P.,Wang, A.H.J. (deposition date: 2005-07-26, release date: 2005-08-23, Last modification date: 2021-11-10) |
Primary citation | Huang, K.F.,Liu, Y.L.,Cheng, W.J.,Ko, T.P.,Wang, A.H. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation Proc.Natl.Acad.Sci.Usa, 102:13117-13122, 2005 Cited by PubMed: 16135565DOI: 10.1073/pnas.0504184102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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