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2ZEM

Crystal structure of the human glutaminyl cyclase mutant D248Q at 2.18 angstrom resolution

Summary for 2ZEM
Entry DOI10.2210/pdb2zem/pdb
Related2AFM 2ZED 2ZEE 2ZEF 2ZEG 2ZEH 2ZEL 2ZEN 2ZEO 2ZEP
DescriptorGlutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ... (4 entities in total)
Functional Keywordshydrogen bond network, glutaminyl cyclase, pyroglutamate, site-directed mutagenesis, proton transfer, acyltransferase, glycoprotein, metal-binding, transferase
Biological sourceHomo sapiens (human)
Cellular locationSecreted: Q16769
Total number of polymer chains2
Total formula weight75463.82
Authors
Huang, K.F.,Wang, Y.R.,Chang, E.C.,Chou, T.L.,Wang, A.H. (deposition date: 2007-12-13, release date: 2008-04-22, Last modification date: 2023-11-01)
Primary citationHuang, K.F.,Wang, Y.R.,Chang, E.C.,Chou, T.L.,Wang, A.H.
A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411:181-190, 2008
Cited by
PubMed: 18072935
DOI: 10.1042/BJ20071073
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.18 Å)
Structure validation

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