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PDB: 21 件
2FLU
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BU of 2flu by Molmil
Crystal Structure of the Kelch-Neh2 Complex
分子名称: Kelch-like ECH-associated protein 1, Nrf2
著者Li, X, Lo, J, Beamer, L, Hannink, M.
登録日2006-01-06
公開日2006-08-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
Embo J., 25, 2006
4IFL
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BU of 4ifl by Molmil
Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes
分子名称: Nrf2 peptide, kelch-like ECH-associated protein 1
著者Pan, H, Lin, M, Yang, Y, Callaway, K, Baker, J, Diep, L, Yan, J, Tanaka, K, Zhu, Y.L, Konradi, A.W, Jobling, M, Tam, D, Ren, Z, Cheung, H, Bova, M, Riley, B.E, Yao, N, Artis, D.R.
登録日2012-12-14
公開日2013-12-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes
Acta Crystallogr.,Sect.D
8HZ8
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BU of 8hz8 by Molmil
Structure of PPIA in complex with the peptide of NRF2
分子名称: NRF2 peptide, Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
著者Wanyan, W, Hui, M, Jin, H, Lu, W.
登録日2023-01-08
公開日2024-03-13
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structure of PPIA in complex with the peptide of NRF2
To Be Published
7K2A
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BU of 7k2a by Molmil
Kelch domain of human KEAP1 bound to Nrf2 peptide, LDEETGEFA
分子名称: ACE-LEU-ASP-GLU-GLU-THR-GLY-GLU-PHE-ALA-NH2, Kelch-like ECH-associated protein 1
著者Muellers, S.N, Allen, K.N.
登録日2020-09-08
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
J.Am.Chem.Soc., 143, 2021
5WFV
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BU of 5wfv by Molmil
Kelch domain of human Keap1 bound to Nrf2 ETGE peptide
分子名称: Kelch-like ECH-associated protein 1, Nrf2 ETGE peptide, SULFATE ION
著者Carolan, J.P, Lynch, A.J, Allen, K.N.
登録日2017-07-12
公開日2018-09-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).
Biochemistry, 59, 2020
7K2K
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BU of 7k2k by Molmil
Kelch domain of human KEAP1 bound to Nrf2 cyclic peptide, c[BAL-DEETGE]
分子名称: BAL-ASP-GLU-GLU-THR-GLY-GLU, Kelch-like ECH-associated protein 1
著者Muellers, S.N, Allen, K.N.
登録日2020-09-08
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
J.Am.Chem.Soc., 143, 2021
7K2E
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BU of 7k2e by Molmil
Kelch domain of human KEAP1 bound to Nrf2-based cyclic peptide, c[GDEETGE]
分子名称: GLY-ASP-GLU-GLU-THR-GLY-GLU, Kelch-like ECH-associated protein 1
著者Muellers, S.N, Allen, K.N.
登録日2020-09-08
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
J.Am.Chem.Soc., 143, 2021
8EJR
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BU of 8ejr by Molmil
Kelch domain of human KEAP1 bound to Nrf2 linear peptide, Ac-GDPETGE-NH2
分子名称: Kelch-like ECH-associated protein 1, Linear peptide from Nuclear factor erythroid 2-related factor 2
著者Muellers, S.N, Allen, K.N.
登録日2022-09-18
公開日2023-09-27
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献The benefit of cyclization: a comparison of cyclic and linear peptide inhibitors of the KEAP1/Nrf2 protein-protein interaction
To Be Published
7K2C
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BU of 7k2c by Molmil
Kelch domain of human KEAP1 bound to Nrf2 peptide, ADEETGEAA
分子名称: Kelch-like ECH-associated protein 1, Nrf2 peptide,ADEETGEAA, SULFATE ION
著者Muellers, S.N, Allen, K.N.
登録日2020-09-08
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
J.Am.Chem.Soc., 143, 2021
7K28
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Kelch domain of human KEAP1 bound to Nrf2 peptide, ADEETGEFL
分子名称: Kelch-like ECH-associated protein 1, Nrf2 peptide,ADEETGEFL
著者Muellers, S.N, Allen, K.N.
登録日2020-09-08
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
J.Am.Chem.Soc., 143, 2021
7K29
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BU of 7k29 by Molmil
Kelch domain of human KEAP1 bound to Nrf2 peptide, LDEETGEAL
分子名称: ACE-LEU-ASP-GLU-GLU-THR-GLY-GLU-ALA-LEU-NH2, Kelch-like ECH-associated protein 1, SULFATE ION
著者Muellers, S.N, Allen, K.N.
登録日2020-09-08
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
J.Am.Chem.Soc., 143, 2021
3ZGC
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BU of 3zgc by Molmil
crystal structure of the KEAP1-NEH2 complex
分子名称: ACETATE ION, KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2
著者Hoerer, S, Reinert, D, Ostmann, K, Hoevels, Y, Nar, H.
登録日2012-12-17
公開日2013-06-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal-Contact Engineering to Obtain a Crystal Form of the Kelch Domain of Human Keap1 Suitable for Ligand-Soaking Experiments.
Acta Crystallogr.,Sect.F, 69, 2013
7K2D
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BU of 7k2d by Molmil
Kelch domain of human KEAP1 bound to Nrf2 linear peptide, Ac-GDEETGE-NH2
分子名称: Kelch-like ECH-associated protein 1, Nrf2 linear peptide, Ace-GDEETGE-NH2
著者Muellers, S.N, Allen, K.N.
登録日2020-09-08
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
J.Am.Chem.Soc., 143, 2021
7X5G
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BU of 7x5g by Molmil
Nrf2 (A510Y)-MafG heterodimer bound with CsMBE2
分子名称: DNA (5'-D(*CP*AP*CP*AP*GP*TP*GP*AP*CP*TP*CP*AP*GP*CP*AP*G)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*TP*GP*AP*GP*TP*CP*AP*CP*TP*GP*T)-3'), Nuclear factor erythroid 2-related factor 2, ...
著者Sengoku, T, Shiina, M, Suzuki, K, Hamada, K, Sato, K, Uchiyama, A, Okada, C, Baba, S, Ohta, T, Motohashi, H, Yamamoto, M, Ogata, K.
登録日2022-03-04
公開日2022-11-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of transcription regulation by CNC family transcription factor, Nrf2.
Nucleic Acids Res., 50, 2022
7X5E
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BU of 7x5e by Molmil
Nrf2-MafG heterodimer bound with CsMBE1
分子名称: DNA (5'-D(*CP*AP*TP*GP*AP*TP*GP*AP*GP*TP*CP*AP*GP*CP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*GP*CP*TP*GP*AP*CP*TP*CP*AP*TP*CP*AP*T)-3'), HEXAETHYLENE GLYCOL, ...
著者Sengoku, T, Shiina, M, Suzuki, K, Hamada, K, Sato, K, Uchiyama, A, Okada, C, Baba, S, Ohta, T, Motohashi, H, Yamamoto, M, Ogata, K.
登録日2022-03-04
公開日2022-11-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of transcription regulation by CNC family transcription factor, Nrf2.
Nucleic Acids Res., 50, 2022
7K2B
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BU of 7k2b by Molmil
Kelch domain of human KEAP1 bound to Nrf2 peptide, ADEETGEFA
分子名称: ACE-ALA-ASP-GLU-GLU-THR-GLY-GLU-PHE-ALA-NH2, Kelch-like ECH-associated protein 1
著者Muellers, S.N, Allen, K.N.
登録日2020-09-08
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
J.Am.Chem.Soc., 143, 2021
6T7V
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BU of 6t7v by Molmil
KEAP1 IN COMPLEX WITH PEPTIDE 8
分子名称: ACETATE ION, Kelch-like ECH-associated protein 1, LEU-ASP-PRO-GLU-THR-GLY-GLU-PHE-LEU
著者Colarusso, S.
登録日2019-10-23
公開日2020-09-09
最終更新日2020-10-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Bioorg.Med.Chem., 28, 2020
7X5F
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BU of 7x5f by Molmil
Nrf2-MafG heterodimer bound with CsMBE2
分子名称: Nuclear factor erythroid 2-related factor 2, Synthetic DNA, Transcription factor MafG
著者Sengoku, T, Shiina, M, Suzuki, K, Hamada, K, Sato, K, Uchiyama, A, Okada, C, Baba, S, Ohta, T, Motohashi, H, Yamamoto, M, Ogata, K.
登録日2022-03-04
公開日2022-11-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis of transcription regulation by CNC family transcription factor, Nrf2.
Nucleic Acids Res., 50, 2022
8EJS
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BU of 8ejs by Molmil
Kelch domain of human KEAP1 bound to Nrf2 linear peptide, Ac-(BAla)DPETGE-NH2
分子名称: Kelch-like ECH-associated protein 1, Peptide from Nuclear factor erythroid 2-related factor 2
著者Muellers, S.N, Allen, K.N.
登録日2022-09-18
公開日2023-09-27
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献The benefit of cyclization: a comparison of cyclic and linear peptide inhibitors of the KEAP1/Nrf2 protein-protein interaction
To Be Published
7O7B
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Solution NMR Structure of the Neh1 Domain of Human Nuclear factor erythroid 2-related factor 2 (NRF2)
分子名称: Isoform 3 of Nuclear factor erythroid 2-related factor 2
著者Brueschweiler, S.
登録日2021-04-13
公開日2021-09-29
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献A Step toward NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods.
Chemmedchem, 16, 2021
2LZ1
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BU of 2lz1 by Molmil
Solution NMR Structure of the DNA-Binding Domain of Human NF-E2-Related Factor 2, Northeast Structural Genomics Consortium (NESG) Target HR3520O
分子名称: Nuclear factor erythroid 2-related factor 2
著者Eletsky, A, Pulavarti, S.V.S.R.K, Lee, D, Kohan, E, Janjua, H, Xiao, R, Acton, T.B, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG)
登録日2012-09-22
公開日2012-11-28
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of the DNA-Binding Domain of Human NF-E2-Related Factor 2, Northeast Structural Genomics Consortium (NESG) Target HR3520O
To be Published

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