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PDB: 113 件

4MEY
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Crystal structure of Escherichia coli RNA polymerase holoenzyme
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H.
登録日2013-08-27
公開日2014-05-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.948 Å)
主引用文献Transcription inhibition by the depsipeptide antibiotic salinamide A.
Elife, 3, 2014
4KN4
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BU of 4kn4 by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2b
分子名称: Benzoxazinorifamycin-2b, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Murakami, K.S.
登録日2013-05-08
公開日2013-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.965 Å)
主引用文献X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
8Y6U
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Cryo-EM structure of E.coli transcription initiation complex with transcription factor GcvA
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Lin, W, Shi, J.
登録日2024-02-03
公開日2024-06-05
実験手法ELECTRON MICROSCOPY (3.97 Å)
主引用文献NMR analysis of a loop-bulge structure of UUCGA pentaloop.
Biochem.Biophys.Res.Commun., 691, 2024
4ZH4
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Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18
分子名称: 5-(4-fluorophenyl)-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-pyrazole, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Feng, Y, Ebright, R.H.
登録日2015-04-24
公開日2015-08-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.993 Å)
主引用文献Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.
Structure, 23, 2015
7VWZ
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Cryo-EM structure of Rob-dependent transcription activation complex in a unique conformation
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Lin, W, Feng, Y, Shi, J.
登録日2021-11-12
公開日2022-06-08
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator.
Nucleic Acids Res., 50, 2022
4XSY
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Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme
分子名称: 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Bae, B, Darst, S.A.
登録日2015-01-22
公開日2015-07-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.007 Å)
主引用文献CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Proc.Natl.Acad.Sci.USA, 112, 2015
6VJS
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Escherichia coli RNA polymerase and ureidothiophene-2-carboxylic acid complex
分子名称: 3-{[benzyl(ethyl)carbamoyl]amino}-5-(4-phenoxyphenyl)thiophene-2-carboxylic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Murakami, K.S, Molodtsov, V.
登録日2020-01-17
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (4.02 Å)
主引用文献Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus -Based Wound Infection Model in SKH1 Mice.
Acs Infect Dis., 6, 2020
6P1K
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Cryo-EM structure of Escherichia coli sigma70 bound RNAP polymerase holoenzyme
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A.
登録日2019-05-20
公開日2020-02-26
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.05 Å)
主引用文献E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation.
Elife, 8, 2019
6JNX
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Cryo-EM structure of a Q-engaged arrested complex
分子名称: Antiterminator Q protein, DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ...
著者Feng, Y, Shi, J.
登録日2019-03-18
公開日2019-06-12
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.08 Å)
主引用文献Structural basis of Q-dependent transcription antitermination.
Nat Commun, 10, 2019
4ZH3
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Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Feng, Y, Ebright, R.H.
登録日2015-04-24
公開日2015-08-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.082 Å)
主引用文献Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.
Structure, 23, 2015
5UAH
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Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
6XH8
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CueR-transcription activation complex with RNA transcript
分子名称: COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Liu, B, Shi, W, Yang, Y.
登録日2020-06-18
公開日2021-04-14
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis of copper-efflux-regulator-dependent transcription activation.
Iscience, 24, 2021
8AD1
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BU of 8ad1 by Molmil
RNA polymerase at U-rich pause bound to RNA putL triple mutant - pause prone, closed clamp state
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Dey, S, Weixlbaumer, A.
登録日2022-07-07
公開日2022-10-19
最終更新日2022-11-02
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
6CUX
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Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Murakami, K.S.
登録日2018-03-26
公開日2018-07-25
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (4.104 Å)
主引用文献Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mol. Cell, 72, 2018
7KHC
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Escherichia coli RNA polymerase and rrnBP1 promoter closed complex
分子名称: CHAPSO, DNA (18 MER), DNA (63-MER), ...
著者Shin, Y, Qayyum, M.Z, Murakami, K.S.
登録日2020-10-20
公開日2020-10-28
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7W5Y
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BU of 7w5y by Molmil
Cryo-EM structure of SoxS-dependent transcription activation complex with fpr promoter DNA
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Lin, W, Feng, Y.
登録日2021-11-30
公開日2022-10-26
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural basis of three different transcription activation strategies adopted by a single regulator SoxS.
Nucleic Acids Res., 50, 2022
7BEG
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BU of 7beg by Molmil
Structures of class I bacterial transcription complexes
分子名称: Class I pacrA promoter non-template DNA, Class I pacrA promoter template DNA, DNA-directed RNA polymerase subunit alpha, ...
著者Ye, F.Z, Hao, M, Zhang, X.D.
登録日2020-12-23
公開日2021-12-01
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation.
Adv Sci, 9, 2022
4JKR
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BU of 4jkr by Molmil
Crystal Structure of E. coli RNA Polymerase in complex with ppGpp
分子名称: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Zuo, Y, Wang, Y, Steitz, T.A.
登録日2013-03-11
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.
Mol.Cell, 50, 2013
4JK2
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X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine pentaphosphate (pppGpp)
分子名称: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ...
著者Murakami, K.S.
登録日2013-03-09
公開日2013-04-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (4.201 Å)
主引用文献Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4ZH2
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Crystal structure of Escherichia coli RNA polymerase in complex with CBR703
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Feng, Y, Ebright, R.H.
登録日2015-04-24
公開日2015-08-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.204 Å)
主引用文献Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.
Structure, 23, 2015
7C17
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The cryo-EM structure of E. coli CueR transcription activation complex with fully duplex promoter DNA
分子名称: DNA (72-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Fang, C.L, Zhang, Y.
登録日2020-05-02
公開日2020-09-30
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.22 Å)
主引用文献CueR activates transcription through a DNA distortion mechanism.
Nat.Chem.Biol., 17, 2021
6C9Y
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Cryo-EM structure of E. coli RNAP sigma70 holoenzyme
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yenool, D, Jiang, W, Murakami, K.S.
登録日2018-01-29
公開日2018-02-28
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.25 Å)
主引用文献Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation.
J. Biol. Chem., 293, 2018
6PB6
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The E. coli class-II CAP-dependent transcription activation complex at the state 2
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Liu, B, Shi, W.
登録日2019-06-13
公開日2020-03-18
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.29 Å)
主引用文献Visualization of two architectures in class-II CAP-dependent transcription activation
Plos Biol., 18, 2020
5VSW
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X-ray crystal structure of Escherichia coli RNA polymerase and DksA/ppGpp complex
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Murakami, K.S, Molodtsov, V.
登録日2017-05-12
公開日2017-06-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (4.295 Å)
主引用文献Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA.
Mol. Cell, 69, 2018
3T72
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PhoB(E)-Sigma70(4)-(RNAP-Betha-flap-tip-helix)-DNA Transcription Activation Sub-Complex
分子名称: PHO BOX DNA (STRAND 1), PHO BOX DNA (STRAND 2), Phosphate regulon transcriptional regulatory protein phoB, ...
著者Blanco, A.G, Canals, A, Bernues, J, Sola, M, Coll, M.
登録日2011-07-29
公開日2011-09-21
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (4.33 Å)
主引用文献The structure of a transcription activation subcomplex reveals how sigma (70) is recruited to PhoB promoters.
Embo J., 30, 2011

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件を2024-07-03に公開中

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