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PDB: 8 件
4JVC
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BU of 4jvc by Molmil
Crystal structure of PqsR co-inducer binding domain
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Transcriptional regulator MvfR
著者Ilangovan, A, Emsley, J, Williams, P.
登録日2013-03-25
公開日2013-08-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR).
Plos Pathog., 9, 2013
8Q5L
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BU of 8q5l by Molmil
PqsR coinducer binding domain of Pseudomonas aeruginosa with ligand 2f: 2-(4-(3-((6-chloro-1-isopropyl-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile
分子名称: 2-[4-[(2~{S})-3-[(6-chloranyl-1-propan-2-yl-benzimidazol-2-yl)amino]-2-oxidanyl-propoxy]phenyl]ethanenitrile, Transcriptional regulator MvfR
著者Markham-Lee, Z.J, Emsley, J.
登録日2023-08-09
公開日2024-01-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Design, Synthesis, and Evaluation of New 1 H -Benzo[ d ]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections.
J.Med.Chem., 67, 2024
4JVI
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BU of 4jvi by Molmil
Crystal structure of PqsR co-inducer binding domain of Pseudomonas aeruginosa with inhibitor 3NH2-7Cl-C9QZN
分子名称: 3-amino-7-chloro-2-nonylquinazolin-4(3H)-one, Transcriptional regulator MvfR
著者Ilangovan, A, Williams, P, Emsley, J.
登録日2013-03-25
公開日2013-08-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR).
Plos Pathog., 9, 2013
6Z07
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BU of 6z07 by Molmil
PqsR (MvfR) in complex with antagonist 12
分子名称: 3-[(2-~{tert}-butyl-1,3-thiazol-4-yl)methyl]-6-chloranyl-quinazolin-4-one, GLYCEROL, Transcriptional regulator MvfR
著者Richardson, W.K, Emsley, J.
登録日2020-05-07
公開日2020-09-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.
Eur.J.Med.Chem., 208, 2020
4JVD
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BU of 4jvd by Molmil
Crystal structure of PqsR coinducer binding domain of Pseudomonas aeruginosa with ligand NHQ
分子名称: 2-nonylquinolin-4(1H)-one, Transcriptional regulator MvfR
著者Ilangovan, A, Emsley, J, Williams, P.
登録日2013-03-25
公開日2013-08-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR).
Plos Pathog., 9, 2013
6Z17
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BU of 6z17 by Molmil
PqsR (MvfR) in complex with antagonist 6
分子名称: 6-chloranyl-3-[(2-propan-2-yl-2,3-dihydro-1,3-thiazol-4-yl)methyl]quinazolin-4-one, Transcriptional regulator MvfR
著者Richardson, W.K, Emsley, J.
登録日2020-05-12
公開日2020-09-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.
Eur.J.Med.Chem., 208, 2020
6TPR
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BU of 6tpr by Molmil
PqsR (MvfR) bound to inhibitory compound 40
分子名称: 2-[(5-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-~{N}-(4-pyridin-2-yloxyphenyl)ethanamide, Transcriptional regulator MvfR
著者Richardson, W.K, Emsley, J.
登録日2019-12-14
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm GrownPseudomonas aeruginosa.
Front Chem, 8, 2020
6Z5K
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BU of 6z5k by Molmil
PqsR (MvfR) in complex with antagonist 18
分子名称: 6-chloranyl-3-[(2-pentyl-2,3-dihydro-1,3-thiazol-4-yl)methyl]quinazolin-4-one, Transcriptional regulator MvfR
著者Richardson, W.K, Emsley, J.
登録日2020-05-26
公開日2020-09-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.201 Å)
主引用文献Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.
Eur.J.Med.Chem., 208, 2020

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件を2024-07-10に公開中

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