6TPR

PqsR (MvfR) bound to inhibitory compound 40

Summary for 6TPR

• Entry DOI: 10.2210/pdb6tpr/pdb
• Descriptor: Transcriptional regulator MvfR, 2-[(5-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-~{N}-(4-pyridin-2-yloxyphenyl)ethanamide (3 entities in total)
• Functional Keywords: pseudomonas aeruginosa, quorum sensing, dna binding protein
• Biological source: Pseudomonas aeruginosa UCBPP-PA14
• Total number of polymer chains: 1
• Total formula weight: 27191.69

Authors

Richardson, W.K.,Emsley, J. (deposition date: 2019-12-14, release date: 2020-05-13, Last modification date: 2024-01-24)

• Primary citation: Soukarieh, F.,Liu, R.,Romero, M.,Roberston, S.N.,Richardson, W.,Lucanto, S.,Oton, E.V.,Qudus, N.R.,Mashabi, A.,Grossman, S.,Ali, S.,Sou, T.,Kukavica-Ibrulj, I.,Levesque, R.C.,Bergstrom, C.A.S.,Halliday, N.,Mistry, S.N.,Emsley, J.,Heeb, S.,Williams, P.,Camara, M.,Stocks, M.J.; Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm GrownPseudomonas aeruginosa.; Front Chem, 8:204-204, 2020; PubMed: 32432073; DOI: 10.3389/fchem.2020.00204

Experimental method

X-RAY DIFFRACTION (3.2 Å)