8WFR
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![BU of 8wfr by Molmil](/molmil-images/mine/8wfr) | The Crystal Structure of PCSK9 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Lu, Y. | 登録日 | 2023-09-20 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Crystal Structure of PCSK9 from Biortus. To Be Published
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4K8R
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8JMW
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![BU of 8jmw by Molmil](/molmil-images/mine/8jmw) | Fibril form of serine peptidase Vpr | 分子名称: | S8 family serine peptidase | 著者 | Cao, Q, Cheng, Y. | 登録日 | 2023-06-05 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM. Nat Commun, 14, 2023
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8U45
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![BU of 8u45 by Molmil](/molmil-images/mine/8u45) | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | 分子名称: | Alkaline protease 1, CALCIUM ION, CHLORIDE ION, ... | 著者 | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | 登録日 | 2023-09-08 | 公開日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
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4YN3
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![BU of 4yn3 by Molmil](/molmil-images/mine/4yn3) | Crystal structure of Cucumisin complex with pro-peptide | 分子名称: | CHLORIDE ION, Cucumisin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Murayama, K, Kato-Murayama, M, Yokoyama, S, Arima, K, Shirouzu, M. | 登録日 | 2015-03-09 | 公開日 | 2016-03-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural basis of cucumisin protease activity regulation by its propeptide J. Biochem., 161, 2017
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5OCA
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![BU of 5oca by Molmil](/molmil-images/mine/5oca) | PCSK9:Fab Complex with Dextran Sulfate | 分子名称: | 2,3,4-tri-O-sulfo-beta-D-altropyranose-(1-6)-2,3-di-O-sulfo-alpha-L-glucopyranose, Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, ... | 著者 | Thirup, S.S, Vilstrup, J.P. | 登録日 | 2017-06-30 | 公開日 | 2017-09-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nat Commun, 8, 2017
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3BPS
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![BU of 3bps by Molmil](/molmil-images/mine/3bps) | PCSK9:EGF-A complex | 分子名称: | CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9 | 著者 | Kwon, H.J. | 登録日 | 2007-12-19 | 公開日 | 2008-02-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Molecular basis for LDL receptor recognition by PCSK9. Proc.Natl.Acad.Sci.Usa, 105, 2008
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1SCJ
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3M0C
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2W2M
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![BU of 2w2m by Molmil](/molmil-images/mine/2w2m) | WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR | 分子名称: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | 著者 | Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. | 登録日 | 2008-11-03 | 公開日 | 2008-11-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
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2W2N
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![BU of 2w2n by Molmil](/molmil-images/mine/2w2n) | WT PCSK9-deltaC bound to EGF-A H306Y mutant of LDLR | 分子名称: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | 著者 | Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A. | 登録日 | 2008-11-03 | 公開日 | 2008-11-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284, 2009
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3P5B
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![BU of 3p5b by Molmil](/molmil-images/mine/3p5b) | The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation | 分子名称: | CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9 | 著者 | Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A. | 登録日 | 2010-10-08 | 公開日 | 2011-10-26 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. Embo Rep., 12, 2011
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3SQO
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![BU of 3sqo by Molmil](/molmil-images/mine/3sqo) | PCSK9 J16 Fab complex | 分子名称: | J16 Heavy chain, J16 Light chain, PCSK9 prodomain, ... | 著者 | Strop, P. | 登録日 | 2011-07-05 | 公開日 | 2012-05-16 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates. J.Pharmacol.Exp.Ther., 340, 2012
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3P5C
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![BU of 3p5c by Molmil](/molmil-images/mine/3p5c) | The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation | 分子名称: | CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9 | 著者 | Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A. | 登録日 | 2010-10-08 | 公開日 | 2011-10-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. Embo Rep., 12, 2011
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7S5H
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![BU of 7s5h by Molmil](/molmil-images/mine/7s5h) | PCSK9(deltaCRD) in complex with cyclic peptide 35 | 分子名称: | (2E)-but-2-ene-1,4-diol, Pro-peptide from Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9, ... | 著者 | Orth, P. | 登録日 | 2021-09-10 | 公開日 | 2021-11-03 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.272 Å) | 主引用文献 | A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors. J.Med.Chem., 64, 2021
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7S5G
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![BU of 7s5g by Molmil](/molmil-images/mine/7s5g) | PCSK9 in complex with compound 19 | 分子名称: | (2E)-but-2-ene-1,4-diol, GLYCEROL, Propeptide of Proprotein convertase subtilisin/kexin type 9, ... | 著者 | Orth, P. | 登録日 | 2021-09-10 | 公開日 | 2021-11-03 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.041 Å) | 主引用文献 | A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors. J.Med.Chem., 64, 2021
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7KFA
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![BU of 7kfa by Molmil](/molmil-images/mine/7kfa) | PCSK9 in complex with PCSK9i a 13mer cyclic peptide LDLR disruptor | 分子名称: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, ... | 著者 | Chopra, R, Xu, M, Spraggon, G. | 登録日 | 2020-10-13 | 公開日 | 2021-11-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Identification of a PCSK9-LDLR disruptor peptide with in vivo function. Cell Chem Biol, 29, 2022
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7KEV
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![BU of 7kev by Molmil](/molmil-images/mine/7kev) | PCSK9 in complex with a cyclic peptide LDLR disruptor | 分子名称: | CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9 Propeptide, ... | 著者 | Spraggon, G, Chopra, R. | 登録日 | 2020-10-12 | 公開日 | 2021-11-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of a PCSK9-LDLR disruptor peptide with in vivo function. Cell Chem Biol, 29, 2022
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3WHI
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![BU of 3whi by Molmil](/molmil-images/mine/3whi) | Crystal structure of unautoprocessed form of IS1-inserted Pro-subtilisin E | 分子名称: | CALCIUM ION, Subtilisin E | 著者 | Uehara, R, Angkawidjaja, C, Koga, Y, Kanaya, S. | 登録日 | 2013-08-26 | 公開日 | 2013-12-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Formation of the High-Affinity Calcium Binding Site in Pro-subtilisin E with the Insertion Sequence IS1 of Pro-Tk-subtilisin Biochemistry, 52, 2013
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4OV6
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![BU of 4ov6 by Molmil](/molmil-images/mine/4ov6) | Crystal structure of PCSK9(53-451) with Adnectin | 分子名称: | 1,2-ETHANEDIOL, Adnectin, Proprotein convertase subtilisin/kexin type 9, ... | 著者 | Khan, J.A. | 登録日 | 2014-02-20 | 公開日 | 2014-07-02 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering. J.Pharmacol.Exp.Ther., 350, 2014
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4NE9
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![BU of 4ne9 by Molmil](/molmil-images/mine/4ne9) | PCSK9 in complex with LDLR peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor, ... | 著者 | Liu, S. | 登録日 | 2013-10-28 | 公開日 | 2014-09-10 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chem.Biol., 21, 2014
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8GKO
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![BU of 8gko by Molmil](/molmil-images/mine/8gko) | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | 分子名称: | 1,2-ETHANEDIOL, Alkaline protease 1, FORMYL GROUP, ... | 著者 | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | 登録日 | 2023-03-20 | 公開日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
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8GKQ
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![BU of 8gkq by Molmil](/molmil-images/mine/8gkq) | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | 分子名称: | 1,2-ETHANEDIOL, Alkaline protease 1, CALCIUM ION, ... | 著者 | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | 登録日 | 2023-03-20 | 公開日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
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8GKP
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![BU of 8gkp by Molmil](/molmil-images/mine/8gkp) | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | 分子名称: | Alkaline protease 1, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... | 著者 | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | 登録日 | 2023-03-20 | 公開日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
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4NMX
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