4NMX

PCSK9(deltaCRD) in complex with phage-derived inhibitory peptide 2-8

Summary for 4NMX

• Entry DOI: 10.2210/pdb4nmx/pdb
• Descriptor: Proprotein convertase subtilisin/kexin type 9, peptide 2-8, ... (4 entities in total)
• Functional Keywords: subtlisin, receptor degradation, ldl receptor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q8NBP7 Q8NBP7
• Total number of polymer chains: 3
• Total formula weight: 48542.43

Authors

Eigenbrot, C.,Shia, S. (deposition date: 2013-11-15, release date: 2013-12-04, Last modification date: 2023-09-20)

• Primary citation: Zhang, Y.,Eigenbrot, C.,Zhou, L.,Shia, S.,Li, W.,Quan, C.,Tom, J.,Moran, P.,Di Lello, P.,Skelton, N.J.,Kong-Beltran, M.,Peterson, A.,Kirchhofer, D.; Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor.; J.Biol.Chem., 289:942-955, 2014; PubMed: 24225950; DOI: 10.1074/jbc.M113.514067

Experimental method

X-RAY DIFFRACTION (1.85 Å)