7RPM
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![BU of 7rpm by Molmil](/molmil-images/mine/7rpm) | |
1OED
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![BU of 1oed by Molmil](/molmil-images/mine/1oed) | STRUCTURE OF ACETYLCHOLINE RECEPTOR PORE FROM ELECTRON IMAGES | 分子名称: | Acetylcholine receptor beta subunit, Acetylcholine receptor delta subunit, Acetylcholine receptor gamma subunit, ... | 著者 | Miyazawa, A, Fujiyoshi, Y, Unwin, N. | 登録日 | 2003-03-24 | 公開日 | 2003-06-26 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure and Gating Mechanism of the Acetylcholine Receptor Pore. Nature, 423, 2003
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1VRY
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![BU of 1vry by Molmil](/molmil-images/mine/1vry) | Second and Third Transmembrane Domains of the Alpha-1 Subunit of Human Glycine Receptor | 分子名称: | Glycine receptor alpha-1 chain | 著者 | Ma, D, Liu, Z, Li, L, Tang, P, Xu, Y. | 登録日 | 2005-07-20 | 公開日 | 2005-07-26 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and Dynamics of the Second and Third Transmembrane Domains of Human Glycine Receptor. Biochemistry, 44, 2005
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2LM2
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![BU of 2lm2 by Molmil](/molmil-images/mine/2lm2) | NMR structures of the transmembrane domains of the AChR b2 subunit | 分子名称: | Neuronal acetylcholine receptor subunit beta-2 | 著者 | Bondarenko, V, Mowrey, D, Tillman, T, Cui, T, Liu, L.T, Xu, Y, Tang, P. | 登録日 | 2011-11-18 | 公開日 | 2012-03-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structures of the transmembrane domains of the a4b2 nAChR. Biochim.Biophys.Acta, 1818, 2012
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2M6I
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![BU of 2m6i by Molmil](/molmil-images/mine/2m6i) | Putative pentameric open-channel structure of full-length transmembrane domains of human glycine receptor alpha1 subunit | 分子名称: | Full-Length Transmembrane Domains of Human Glycine Receptor alpha1 Subunit | 著者 | Mowrey, D, Cui, T, Jia, Y, Ma, D, Makhov, A.M, Zhang, P, Tang, P, Xu, Y. | 登録日 | 2013-03-29 | 公開日 | 2013-09-04 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Open-Channel Structures of the Human Glycine Receptor alpha 1 Full-Length Transmembrane Domain. Structure, 21, 2013
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2M6B
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![BU of 2m6b by Molmil](/molmil-images/mine/2m6b) | Structure of full-length transmembrane domains of human glycine receptor alpha1 monomer subunit | 分子名称: | Full-Length Transmembrane Domains of Human Glycine Receptor alpha1 Subunit | 著者 | Mowrey, D, Cui, T, Jia, Y, Ma, D, Makhov, A.M, Zhang, P, Tang, P, Xu, Y. | 登録日 | 2013-03-28 | 公開日 | 2013-09-04 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Open-Channel Structures of the Human Glycine Receptor alpha 1 Full-Length Transmembrane Domain. Structure, 21, 2013
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2LLY
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![BU of 2lly by Molmil](/molmil-images/mine/2lly) | NMR structures of the transmembrane domains of the nAChR a4 subunit | 分子名称: | Neuronal acetylcholine receptor subunit alpha-4 | 著者 | Bondarenko, V, Mowrey, D, Tillman, T, Cui, T, Liu, L.T, Xu, Y, Tang, P. | 登録日 | 2011-11-18 | 公開日 | 2012-03-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structures of the transmembrane domains of the a4b2 nAChR. Biochim.Biophys.Acta, 1818, 2012
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2KSR
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![BU of 2ksr by Molmil](/molmil-images/mine/2ksr) | |
2MAW
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![BU of 2maw by Molmil](/molmil-images/mine/2maw) | |
8F4V
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![BU of 8f4v by Molmil](/molmil-images/mine/8f4v) | Alpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin in a desensitized state | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, Neuronal acetylcholine receptor subunit alpha-7 | 著者 | Bondarenko, V, Chen, Q, Tang, P. | 登録日 | 2022-11-11 | 公開日 | 2023-02-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Elucidation of Ivermectin Binding to alpha 7nAChR and the Induced Channel Desensitization. Acs Chem Neurosci, 14, 2023
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4TNV
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![BU of 4tnv by Molmil](/molmil-images/mine/4tnv) | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, CHLORIDE ION, ... | 著者 | Althoff, T, Hibbs, R.E, Banerjee, S, Gouaux, E. | 登録日 | 2014-06-05 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors. Nature, 512, 2014
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7Z14
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![BU of 7z14 by Molmil](/molmil-images/mine/7z14) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with a short-chain neurotoxin. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine receptor subunit alpha, ... | 著者 | Nys, M.A.E.M, Zarkadas, E, Ulens, C, Nury, H. | 登録日 | 2022-02-24 | 公開日 | 2022-08-17 | 最終更新日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | The molecular mechanism of snake short-chain alpha-neurotoxin binding to muscle-type nicotinic acetylcholine receptors. Nat Commun, 13, 2022
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3JAD
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![BU of 3jad by Molmil](/molmil-images/mine/3jad) | Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, strychnine-bound state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1, STRYCHNINE | 著者 | Du, J, Lu, W, Wu, S.P, Cheng, Y.F, Gouaux, E. | 登録日 | 2015-06-08 | 公開日 | 2015-09-09 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature, 526, 2015
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7A5V
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![BU of 7a5v by Molmil](/molmil-images/mine/7a5v) | CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W. | 登録日 | 2020-08-22 | 公開日 | 2020-11-18 | 最終更新日 | 2020-11-25 | 実験手法 | ELECTRON MICROSCOPY (1.7 Å) | 主引用文献 | Single-particle cryo-EM at atomic resolution. Nature, 587, 2020
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2BG9
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6NP0
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![BU of 6np0 by Molmil](/molmil-images/mine/6np0) | Cryo-EM structure of 5HT3A receptor in presence of granisetron | 分子名称: | 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Basak, S, Chakrapani, S. | 登録日 | 2019-01-17 | 公開日 | 2019-07-24 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Molecular mechanism of setron-mediated inhibition of full-length 5-HT3Areceptor. Nat Commun, 10, 2019
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4X5T
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![BU of 4x5t by Molmil](/molmil-images/mine/4x5t) | alpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC | 分子名称: | ACETATE ION, CHLORIDE ION, NICKEL (II) ION, ... | 著者 | Sauguet, L, Corringer, P.J, Huon, C, Delarue, M. | 登録日 | 2014-12-05 | 公開日 | 2015-02-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Allosteric and hyperekplexic mutant phenotypes investigated on an alpha 1 glycine receptor transmembrane structure. Proc.Natl.Acad.Sci.USA, 112, 2015
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5KXI
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![BU of 5kxi by Molmil](/molmil-images/mine/5kxi) | X-ray structure of the human Alpha4Beta2 nicotinic receptor | 分子名称: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuronal acetylcholine receptor subunit alpha-4, ... | 著者 | Morales-Perez, C.L, Noviello, C.M, Hibbs, R.E. | 登録日 | 2016-07-20 | 公開日 | 2016-09-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.941 Å) | 主引用文献 | X-ray structure of the human alpha 4 beta 2 nicotinic receptor. Nature, 538, 2016
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6PXD
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![BU of 6pxd by Molmil](/molmil-images/mine/6pxd) | CryoEM structure of zebra fish alpha-1 glycine receptor, Apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glycine receptor subunit alphaZ1 | 著者 | Du, J, Lu, W, Gouaux, E. | 登録日 | 2019-07-25 | 公開日 | 2021-02-10 | 最終更新日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6QFA
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![BU of 6qfa by Molmil](/molmil-images/mine/6qfa) | CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3, HISTAMINE, ... | 著者 | Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkoening, A, Zoegg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J. | 登録日 | 2019-01-09 | 公開日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | 主引用文献 | Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM. Nat.Methods, 18, 2021
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8AW2
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![BU of 8aw2 by Molmil](/molmil-images/mine/8aw2) | Mouse serotonin 5-HT3A receptor in complex with vortioxetine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2022-08-29 | 公開日 | 2024-03-06 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 2024
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8AXD
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![BU of 8axd by Molmil](/molmil-images/mine/8axd) | Human serotonin 5-HT3A receptor (apo, resting conformation) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2022-08-31 | 公開日 | 2024-03-06 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 2024
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4PIR
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![BU of 4pir by Molmil](/molmil-images/mine/4pir) | X-ray structure of the mouse serotonin 5-HT3 receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Hassaine, G, Deluz, C, Grasso, L, Wyss, R, Tol, M.B, Hovius, R, Graff, A, Stahlberg, H, Tomizaki, T, Desmyter, A, Moreau, C, Li, X.-D, Poitevin, F, Vogel, H, Nury, H. | 登録日 | 2014-05-09 | 公開日 | 2014-08-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | X-ray structure of the mouse serotonin 5-HT3 receptor. Nature, 512, 2014
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3JAF
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![BU of 3jaf by Molmil](/molmil-images/mine/3jaf) | Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1 | 著者 | Du, J, Lu, W, Wu, S.P, Cheng, Y.F, Gouaux, E. | 登録日 | 2015-06-08 | 公開日 | 2015-09-09 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.801 Å) | 主引用文献 | Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature, 526, 2015
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3JAE
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![BU of 3jae by Molmil](/molmil-images/mine/3jae) | Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine-bound state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1 | 著者 | Du, J, Lu, W, Wu, S.P, Cheng, Y.F, Gouaux, E. | 登録日 | 2015-06-08 | 公開日 | 2015-09-09 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature, 526, 2015
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