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PDB: 163 件
5XEJ
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Crystal Structure of Macrophage Migration Inhibitory Factor bound to MTX
分子名称: (2~{R})-2-[[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid, Macrophage migration inhibitory factor, SULFATE ION
著者Takimoto-Kamimura, M, Fukushima, K.
登録日2017-04-05
公開日2018-07-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of macrophage migration inhibitory factor in complex with methotrexate.
Acta Crystallogr D Struct Biol, 77, 2021
3DJH
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Macrophage Migration Inhibitory Factor (MIF) at 1.25 A Resolution
分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
著者Crichlow, G.V, Lolis, E.
登録日2008-06-23
公開日2008-12-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.
Biochemistry, 48, 2009
8IMR
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Structure of ligand-free human macrophage migration inhibitory factor
分子名称: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
著者Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H.
登録日2023-03-07
公開日2024-03-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis
To Be Published
1UIZ
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BU of 1uiz by Molmil
Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.
分子名称: Macrophage Migration Inhibitory Factor
著者Suzuki, M, Takamura, Y, Maeno, M, Tochinai, S, Iyaguchi, D, Tanaka, I, Nishihira, J, Ishibashi, T.
登録日2003-07-24
公開日2004-05-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Xenopus laevis Macrophage Migration Inhibitory Factor Is Essential for Axis Formation and Neural Development.
J.Biol.Chem., 279, 2004
8AP3
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Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2)
分子名称: MIF homologue
著者Manjula, R, Basquin, J, Lolis, E.
登録日2022-08-09
公開日2023-08-23
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2)
To Be Published
6ICE
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BU of 6ice by Molmil
Crystal structure of Hamster MIF
分子名称: Macrophage migration inhibitory factor
著者Sundaram, R, Vasudevan, D.
登録日2018-09-05
公開日2019-09-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Macrophage migration inhibitory factor of Syrian golden hamster shares structural and functional similarity with human counterpart and promotes pancreatic cancer.
Sci Rep, 9, 2019
1P1G
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH PRO-1 MUTATED TO GLY-1
分子名称: PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
著者Lubetsky, J.B, Lolis, E.
登録日1999-03-24
公開日1999-06-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.
Biochemistry, 38, 1999
5EIZ
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Crystal structure of Y99A mutant of human macrophage migration inhibitory factor
分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
著者Pantouris, G, Lolis, E.
登録日2015-10-30
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.
Angew. Chem. Int. Ed. Engl., 2018
2GDG
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Crystal structure of covalently modified macrophage inhibitory factor
分子名称: Macrophage migration inhibitory factor
著者Golubkov, P.A, Hackert, M.L.
登録日2006-03-16
公開日2006-07-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate.
Bioorg.Chem., 34, 2006
4WRB
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Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-190)
分子名称: 4-{4-[6-(2-methoxyethoxy)quinolin-2-yl]-1H-1,2,3-triazol-1-yl}phenol, GLYCEROL, ISOPROPYL ALCOHOL, ...
著者Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L.
登録日2014-10-23
公開日2015-03-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor.
J.Am.Chem.Soc., 137, 2015
2WKF
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Crystal Structure of Macrophage Migration Inhibitory Factor from Plasmodium falciparum
分子名称: GLYCEROL, MACROPHAGE MIGRATION INHIBITORY FACTOR
著者Dobson, S.E, Augustijn, K.D, Brannigan, J.A, Dodson, E.J, Waters, A.P, Wilkinson, A.J.
登録日2009-06-11
公開日2009-10-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei.
Protein Sci., 18, 2009
4WR8
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Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-180)
分子名称: 4-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]phenol, Macrophage migration inhibitory factor, SODIUM ION, ...
著者Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L.
登録日2014-10-23
公開日2015-03-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor.
J.Am.Chem.Soc., 137, 2015
5J7Q
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Macrophage Migration Inhibitory Factor bound to Inhibitor K664 Derivative
分子名称: 4-(imidazo[1,2-a]pyridin-2-yl)benzene-1,2-diol, GLYCEROL, ISOPROPYL ALCOHOL, ...
著者Robertson, M.J, Jorgensen, W.L.
登録日2016-04-06
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Irregularities in enzyme assays: The case of macrophage migration inhibitory factor.
Bioorg.Med.Chem.Lett., 26, 2016
5J7P
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Macrophage Migration Inhibitory Factor bound to Covalent Inhibitor RDR03785
分子名称: 6-{[4-(trifluoromethyl)phenyl]methyl}-2H-1,3-benzodioxol-5-ol, GLYCEROL, ISOPROPYL ALCOHOL, ...
著者Robertson, M.J, Jorgensen, W.L.
登録日2016-04-06
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Irregularities in enzyme assays: The case of macrophage migration inhibitory factor.
Bioorg.Med.Chem.Lett., 26, 2016
7XTX
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High resolution crystal structure of human macrophage migration inhibitory factor in complex with methotrexate
分子名称: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
著者Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H.
登録日2022-05-18
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis
To Be Published
7XVX
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Neutron crystal structure of human macrophage migration inhibitory factor
分子名称: Macrophage migration inhibitory factor
著者Ezawa, T, Tamada, T, Odaka, M, Matsumura, H.
登録日2022-05-25
公開日2023-05-31
最終更新日2024-04-03
実験手法NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION
主引用文献Neutron crystal structure of human macrophage migration inhibitory factor
To Be Published
2XCZ
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BU of 2xcz by Molmil
Crystal Structure of macrophage migration inhibitory factor homologue from Prochlorococcus marinus
分子名称: DI(HYDROXYETHYL)ETHER, POSSIBLE ATLS1-LIKE LIGHT-INDUCIBLE PROTEIN
著者Wasiel, A.A, Rozeboom, H.J, Hauke, D, Baas, B.J, Zandvoort, E, Quax, W.J, Thunnissen, A.M.W.H, Poelarends, G.J.
登録日2010-04-27
公開日2010-09-01
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Structural and Functional Characterization of a Macrophage Migration Inhibitory Factor Homologue from the Marine Cyanobacterium Prochlorococcus Marinus.
Biochemistry, 49, 2010
6FVE
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Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound FITC
分子名称: 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-[(E)-(sulfanylmethylidene)amino]benzoic acid, Macrophage migration inhibitory factor, SULFATE ION
著者Samygina, V.R, Bourenkov, G, Sokolov, A.V.
登録日2018-03-02
公開日2018-06-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor.
Biochemistry Mosc., 83, 2018
6FVH
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Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound PITC
分子名称: Macrophage migration inhibitory factor, N-phenylthioformamide, SULFATE ION
著者Samygina, V.R, Bourenkov, G, Sokolov, A.V.
登録日2018-03-02
公開日2018-06-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor.
Biochemistry Mosc., 83, 2018
1CA7
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXPHENYLPYRUVATE
分子名称: 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
著者Lubetsky, J.B, Lolis, E.
登録日1999-02-25
公開日1999-06-30
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.
Biochemistry, 38, 1999
5HVS
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Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Biaryltriazole Inhibitor (3i-305)
分子名称: 3-({2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]quinolin-5-yl}oxy)benzoic acid, GLYCEROL, Macrophage migration inhibitory factor, ...
著者Robertson, M.J, Jorgensen, W.L.
登録日2016-01-28
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors.
J.Am.Chem.Soc., 138, 2016
9B0M
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Crystal structure of Macrophage migration inhibitory factor from Plasmodium vivax
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, L-dopachrome isomerase
著者Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2024-03-12
公開日2024-03-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of Macrophage migration inhibitory factor from Plasmodium vivax
To be published
9BNQ
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N-(4-(isothiocyanatomethyl)phenyl)methanesulfonamide complexed with Macrophage Migration Inhibitory Factor
分子名称: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, N-{[4-(methanesulfonamido)phenyl]methyl}methanethioamide, ...
著者Fellner, M, Rutledge, M.T, Putha, L, Kok, L.K, Gamble, A.B, Wilbanks, S.M, Vernall, A.J, Tyndall, J.D.A.
登録日2024-05-02
公開日2024-07-24
実験手法X-RAY DIFFRACTION (1.09 Å)
主引用文献Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments.
Chemmedchem, 2024
9BNR
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4-(2-isothiocyanatoethyl)benzenesulfonamide complexed with Macrophage Migration Inhibitory Factor
分子名称: Macrophage migration inhibitory factor, N-[2-(4-sulfamoylphenyl)ethyl]methanethioamide, SULFATE ION
著者Fellner, M, Rutledge, M.T, Putha, L, Kok, L.K, Gamble, A.B, Wilbanks, S.M, Vernall, A.J, Tyndall, J.D.A.
登録日2024-05-02
公開日2024-07-24
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments.
Chemmedchem, 2024
5HVT
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Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Potent Inhibitor (NVS-2)
分子名称: 7-hydroxy-3-(4-methoxyphenyl)-3,4-dihydro-2H-1,3-benzoxazin-2-one, GLYCEROL, ISOPROPYL ALCOHOL, ...
著者Robertson, M.J, Jorgensen, W.L.
登録日2016-01-28
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors.
J.Am.Chem.Soc., 138, 2016

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