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PDB: 61 件

4WA8
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Methanopyrus Kandleri FEN-1 nuclease
分子名称: CHLORIDE ION, Flap endonuclease 1
著者Shah, S, Dunten, P, Horton, N.C.
登録日2014-08-28
公開日2014-11-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure and specificity of FEN-1 from Methanopyrus kandleri.
Proteins, 83, 2015
5FV7
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Human Fen1 in complex with an N-hydroxyurea compound
分子名称: 1-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, FLAP ENDONUCLEASE 1, MAGNESIUM ION
著者Exell, J.C, Thompson, M.J, Finger, L.D, Shaw, S.K, Abbott, W.M, McWhirter, C, Debreczeni, J.E, Jones, C.D, Nissink, J.W.M, Ward, T.A, Sioberg, C.W.L, Molina, D.M, Durant, S.T, Grasby, J.A.
登録日2016-02-03
公開日2016-08-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Cellular Active N-Hydroxyurea Fen1 Inhibitors Block Substrate Entry to the Active Site
Nat.Chem.Biol., 12, 2016
6VBH
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Human XPG endonuclease catalytic domain
分子名称: DNA repair protein complementing XP-G cells,Flap endonuclease 1, SULFATE ION
著者Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
登録日2019-12-18
公開日2020-06-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.995 Å)
主引用文献Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.
Proc.Natl.Acad.Sci.USA, 117, 2020
2IZO
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Structure of an Archaeal PCNA1-PCNA2-FEN1 Complex
分子名称: DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE, ...
著者Dore, A.S, Kilkenny, M.L, Roe, S.M, Pearl, L.H.
登録日2006-07-25
公開日2006-09-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of an Archaeal PCNA1-PCNA2-Fen1 Complex: Elucidating PCNA Subunit and Client Enzyme Specificity.
Nucleic Acids Res., 34, 2006
7QO1
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complex of DNA ligase I and FEN1 on PCNA and DNA
分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Flap endonuclease 1, ...
著者Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A.
登録日2021-12-23
公開日2023-01-11
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
3ORY
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Crystal structure of Flap endonuclease 1 from hyperthermophilic archaeon Desulfurococcus amylolyticus
分子名称: PHOSPHATE ION, flap endonuclease 1
著者Mase, T, Kubota, K, Miyazono, K, Kawarabayashii, Y, Tanokura, M.
登録日2010-09-08
公開日2011-02-09
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus
Acta Crystallogr.,Sect.F, 67, 2011
5T9J
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Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface
分子名称: DNA (5'-D(*DAP*DCP*DGP*DAP*DTP*DGP*DGP*DAP*DGP*DCP*DCP*DGP*DCP*DTP*DAP*DGP*DGP*DCP*DTP*DC)-3'), DNA (5'-D(*DGP*DAP*DAP*DTP*DTP*DCP*DCP*DGP*DGP*DAP*DTP*DTP*DAP*DGP*DGP*DGP*DAP*DTP*DGP*DC)-3'), DNA (5'-D(*DGP*DAP*DGP*DCP*DCP*DTP*DAP*DGP*DCP*DGP*DTP*DCP*DCP*DGP*DGP*DAP*DAP*DTP*DTP*DC)-3'), ...
著者Lee, S.-H, Biertumpfel, C.
登録日2016-09-09
公開日2016-09-21
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.00012732 Å)
主引用文献Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
Elife, 4, 2015
1MC8
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Crystal Structure of Flap Endonuclease-1 R42E mutant from Pyrococcus horikoshii
分子名称: Flap Endonuclease-1
著者Matsui, E, Musti, K.V, Abe, J, Yamazaki, K, Matsui, I, Harata, K.
登録日2002-08-06
公開日2002-10-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Molecular Structure and Novel DNA Binding Sites Located in Loops of Flap Endonuclease-1 from Pyrococcus horikoshii
J.BIOL.CHEM., 277, 2002
5K97
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Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+
分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), ...
著者Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
登録日2016-05-31
公開日2017-06-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
5CNQ
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Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA, Mg2+ and Mn2+ ions
分子名称: DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MANGANESE (II) ION, Nuclease-like protein, ...
著者Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J.
登録日2015-07-17
公開日2015-12-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.602 Å)
主引用文献Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.
Cell Rep, 13, 2015
5KSE
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Flap endonuclease 1 (FEN1) R100A with 5'-flap substrate DNA and Sm3+
分子名称: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*AP*AP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
著者Tsutakawa, S.E, Arvai, A.S, Tainer, J.A.
登録日2016-07-08
公開日2017-06-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.105 Å)
主引用文献Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
5CO8
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Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA and Mg2+ ion
分子名称: DNA (31-MER), DNA (5'-D(*AP*GP*AP*CP*TP*GP*CP*AP*GP*TP*TP*GP*AP*GP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*A)-3'), ...
著者Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J.
登録日2015-07-20
公開日2016-01-13
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.
Cell Rep, 13, 2015
1RXW
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Crystal structure of A. fulgidus FEN-1 bound to DNA
分子名称: 5'-d(*C*pG*pA*pT*pG*pC*pT*pA)-3', 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG)-3', Flap structure-specific endonuclease
著者Chapados, B.R, Hosfield, D.J, Han, S, Qiu, J, Yelent, B, Shen, B, Tainer, J.A.
登録日2003-12-18
公開日2004-01-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1UL1
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Crystal structure of the human FEN1-PCNA complex
分子名称: Flap endonuclease-1, MAGNESIUM ION, Proliferating cell nuclear antigen
著者Sakurai, S, Kitano, K, Yamaguchi, H, Hamada, K, Okada, K, Fukuda, K, Uchida, M, Ohtsuka, E, Morioka, H, Hakoshima, T.
登録日2003-09-05
公開日2005-03-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for recruitment of human flap endonuclease 1 to PCNA
EMBO J., 24, 2005
6GRC
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eukaryotic junction-resolving enzyme GEN-1 binding with Sodium
分子名称: DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MAGNESIUM ION, ...
著者Lilley, D.M.J, Liu, Y, Freeman, D.J.
登録日2018-06-11
公開日2018-09-26
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.452 Å)
主引用文献A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
6GRD
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eukaryotic junction-resolving enzyme GEN-1 binding with Cesium
分子名称: CESIUM ION, DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), ...
著者Lilley, D.M.J, Liu, Y, Freeman, D.J.
登録日2018-06-11
公開日2018-09-26
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
1RXV
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Crystal Structure of A. Fulgidus FEN-1 bound to DNA
分子名称: 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG), Flap structure-specific endonuclease
著者Chapados, B.R, Hosfield, D.J, Han, S, Qiu, J, Yelent, B, Shen, B, Tainer, J.A.
登録日2003-12-18
公開日2004-01-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
6GRB
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eukaryotic junction-resolving enzyme GEN-1 binding with Potassium
分子名称: DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MAGNESIUM ION, ...
著者Lilley, D.M.J, Liu, Y, Freeman, D.J.
登録日2018-06-11
公開日2018-09-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
1A77
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FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
分子名称: FLAP ENDONUCLEASE-1 PROTEIN, MAGNESIUM ION
著者Hwang, K.Y, Baek, K, Kim, H, Cho, Y.
登録日1998-03-20
公開日1999-08-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
1B43
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FEN-1 FROM P. FURIOSUS
分子名称: PROTEIN (FEN-1)
著者Hosfield, D.J, Mol, C.D, Shen, B, Tainer, J.A.
登録日1999-01-05
公開日2000-01-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Cell(Cambridge,Mass.), 95, 1998
1A76
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FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
分子名称: FLAP ENDONUCLEASE-1 PROTEIN, MANGANESE (II) ION
著者Hwang, K.Y, Baek, K, Kim, H, Cho, Y.
登録日1998-03-20
公開日1999-08-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
5ZOF
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Crystal Structure of D181A/R192F hFen1 in complex with DNA
分子名称: DNA (5'-D(*AP*CP*TP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ...
著者Han, W, Hua, Y, Zhao, Y.
登録日2018-04-13
公開日2019-01-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.249 Å)
主引用文献Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018
5ZOE
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Crystal Structure of D181A hFen1 in complex with DNA
分子名称: DNA (5'-D(*AP*CP*TP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ...
著者Han, W, Hua, Y, Zhao, Y.
登録日2018-04-13
公開日2019-01-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018
5ZOD
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Crystal Structure of hFen1 in apo form
分子名称: Flap endonuclease 1, MAGNESIUM ION, POTASSIUM ION
著者Han, W, Hua, Y, Zhao, Y.
登録日2018-04-13
公開日2019-01-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018
5ZOG
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Crystal Structure of R192F hFen1 in complex with DNA
分子名称: DNA (5'-D(*CP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*GP*AP*T)-3'), DNA (5'-D(P*TP*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), ...
著者Han, W, Hua, Y, Zhao, Y.
登録日2018-04-13
公開日2019-01-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.299 Å)
主引用文献Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018

 

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