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PDB: 393 件
8WI5
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M5PI-bound hMRP5
分子名称: ATP-binding cassette sub-family C member 5
著者Liu, Z.M, Huang, Y.
登録日2023-09-24
公開日2024-07-03
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
8WI4
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m6-hMRP5 inward open
分子名称: ATP-binding cassette sub-family C member 5
著者Liu, Z.M, Huang, Y.
登録日2023-09-24
公開日2024-07-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
8XOK
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Cryo-EM structure of human ABCC4
分子名称: 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ATP-binding cassette sub-family C member 4, PALMITIC ACID
著者Zhang, P.F, Liu, Z.
登録日2024-01-01
公開日2024-07-24
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (2.84 Å)
主引用文献The ATP-bound inward-open conformation of ABCC4 reveals asymmetric ATP binding for substrate transport.
Febs Lett., 598, 2024
8XOL
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Cryo-EM structure of human ABCC4 with ANP bound in NBD1
分子名称: 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ATP-binding cassette sub-family C member 4, MAGNESIUM ION, ...
著者Zhang, P.F, Liu, Z.
登録日2024-01-01
公開日2024-07-17
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (3.02 Å)
主引用文献The ATP-bound inward-open conformation of ABCC4 reveals asymmetric ATP binding for substrate transport.
Febs Lett., 598, 2024
8XOM
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Cryo-EM structure of human ABCC4 in complex with ANP-bound in NBD1 and METHOTREXATE
分子名称: 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ATP-binding cassette sub-family C member 4, MAGNESIUM ION, ...
著者Zhang, P.F, Liu, Z.
登録日2024-01-01
公開日2024-07-17
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献The ATP-bound inward-open conformation of ABCC4 reveals asymmetric ATP binding for substrate transport.
Febs Lett., 598, 2024
8I4B
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Cryo-EM structure of apo-form ABCC4
分子名称: ATP-binding cassette sub-family C member 4
著者Chen, Y, Wang, L, Hou, W.T, Zhou, C.Z, Chen, Y, Li, Q.
登録日2023-01-19
公開日2023-05-24
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Cryo-EM structure ofABCC4
Nat Cardiovasc Res, 2023
8I4A
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Cryo-EM structure of dipyridamole-bound ABCC4
分子名称: 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol, ATP-binding cassette sub-family C member 4
著者Chen, Y, Wang, L, Hou, W.T, Zhou, C.Z, Chen, Y, Li, Q.
登録日2023-01-19
公開日2023-05-24
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structure ofABCC4
Nat Cardiovasc Res, 2023
8I4C
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Cryo-EM structure of U46619-bound ABCC4
分子名称: (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, ATP-binding cassette sub-family C member 4
著者Chen, Y, Wang, L, Hou, W.T, Zhou, C.Z, Chen, Y, Li, Q.
登録日2023-01-19
公開日2023-05-24
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Cryo-EM structure ofABCC4
Nat Cardiovasc Res, 2023
8HW4
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Cryo-EM structure of dehydroepiandrosterone sulfate-bound human ABC transporter ABCC3 in nanodiscs
分子名称: 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, ATP-binding cassette sub-family C member 3
著者Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z.
登録日2022-12-28
公開日2023-06-07
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
8HVH
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Cryo-EM structure of ABC transporter ABCC3
分子名称: ATP-binding cassette sub-family C member 3
著者Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z.
登録日2022-12-26
公開日2023-06-07
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
8HW2
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Cryo-EM structure of beta-estradiol 17-(beta-D-glucuronide)-bound human ABC transporter ABCC3 in nanodiscs
分子名称: ATP-binding cassette sub-family C member 3, Estradiol-17beta-glucuronide
著者Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z.
登録日2022-12-28
公開日2023-06-07
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
8IPT
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Cryo-EM structure of heme transporter CydDC from Escherichia coli in the occluded ATP bound state
分子名称: ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC, ...
著者Zhu, C, Li, J.
登録日2023-03-14
公開日2023-06-14
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structures of a prokaryotic heme transporter CydDC.
Protein Cell, 14, 2023
8IPS
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Cryo-EM structure of heme transporter CydDC from Escherichia coli in the inward facing heme loading state
分子名称: ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC, ...
著者Zhu, C, Li, J.
登録日2023-03-14
公開日2023-06-14
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM structures of a prokaryotic heme transporter CydDC.
Protein Cell, 14, 2023
8IPR
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Cryo-EM structure of heme transporter CydDC from Mycobacterium smegmatis in the outward facing ATP bound state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Component linked with the assembly of cytochrome' ABC transporter ATP-binding protein CydC, MAGNESIUM ION, ...
著者Zhu, C, Li, J.
登録日2023-03-14
公開日2023-06-14
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM structures of a prokaryotic heme transporter CydDC.
Protein Cell, 14, 2023
8IPQ
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Cryo-EM structure of heme transporter CydDC from Mycobacterium smegmatis in the inward facing apo state
分子名称: Component linked with the assembly of cytochrome' ABC transporter ATP-binding protein CydC, Transmembrane ATP-binding protein ABC transporter cydD
著者Zhu, C, Li, J.
登録日2023-03-14
公開日2023-06-14
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structures of a prokaryotic heme transporter CydDC.
Protein Cell, 14, 2023
8Y6H
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P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent
分子名称: ATP-dependent translocase ABCB1,mNeonGreen, UIC2 Fab heavy chain, UIC2 Fab light chain, ...
著者Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T.
登録日2024-02-02
公開日2024-04-17
実験手法ELECTRON MICROSCOPY (2.49 Å)
主引用文献Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.
Biochem.Biophys.Res.Commun., 709, 2024
8Y6I
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P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, ATP-dependent translocase ABCB1,mNeonGreen, CHOLESTEROL, ...
著者Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T.
登録日2024-02-02
公開日2024-04-17
実験手法ELECTRON MICROSCOPY (2.54 Å)
主引用文献Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.
Biochem.Biophys.Res.Commun., 709, 2024
5W81
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Phosphorylated, ATP-bound structure of zebrafish cystic fibrosis transmembrane conductance regulator (CFTR)
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION
著者Zhang, Z, Liu, F, Chen, J.
登録日2017-06-21
公開日2017-07-19
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献Conformational Changes of CFTR upon Phosphorylation and ATP Binding.
Cell, 170, 2017
5WUA
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Structure of a Pancreatic ATP-sensitive Potassium Channel
分子名称: ATP-sensitive inward rectifier potassium channel 11,superfolder GFP, SUR1
著者Li, N, Wu, J.-X, Chen, L, Gao, N.
登録日2016-12-16
公開日2017-01-25
実験手法ELECTRON MICROSCOPY (5.6 Å)
主引用文献Structure of a Pancreatic ATP-Sensitive Potassium Channel
Cell, 168, 2017
8FWK
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CryoEM structure of Human ABCB6 Transporter
分子名称: ATP-binding cassette sub-family B member 6
著者Shaik, M.M, Myasnikov, A.
登録日2023-01-22
公開日2023-02-08
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献CryoEM structure of Human ABCB6 Transporter
To Be Published
8FMV
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Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to substrate and ATP: BmrCD_IF-2HT/ATP
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Tang, Q, Mchaourab, H.
登録日2022-12-24
公開日2023-11-15
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8FHK
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Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ATP: BmrCD_OC-ATP
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Tang, Q, Mchaourab, H.
登録日2022-12-14
公開日2023-11-15
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nat Commun, 14, 2023
8FPF
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Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ...
著者Qingyu, T, Hassane, M.
登録日2023-01-04
公開日2023-11-22
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter
Nat Commun, 14, 2023
8GK7
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MsbA bound to cerastecin C
分子名称: 2-[(4-butylbenzene-1-sulfonyl)amino]-5-[(3-{4-[(4-butylbenzene-1-sulfonyl)amino]-3-carboxyanilino}-3-oxopropyl)carbamoyl]benzoic acid, Lipid A export ATP-binding/permease protein MsbA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Chen, Y, Klein, D.
登録日2023-03-17
公開日2024-04-24
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii.
Nat Microbiol, 9, 2024
8GLS
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Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and Z1834339853
分子名称: (2S)-1-(3-amino-6-fluoro-1H-indazol-1-yl)-2-methyl-3-phenoxypropan-1-one, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Liu, F, Chen, J.
登録日2023-03-23
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structure-based discovery of positive and negative CFTR modulators
To Be Published

224931

件を2024-09-11に公開中

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