5W6K
 
 | | Structure of mutant Taq Polymerase incorporating unnatural base pairs Z:P | | 分子名称: | (1R)-1-[6-amino-5-(dihydroxyamino)-2-hydroxypyridin-3-yl]-1,4-anhydro-2-deoxy-5-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-erythro-pentitol, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), DNA (5'-D(P*(1WA)P*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... | | 著者 | Singh, I, Georgiadis, M.M. | | 登録日 | 2017-06-16 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.339 Å) | | 主引用文献 | Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide.
Nucleic Acids Res., 46, 2018
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8JRB
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5DKU
 | | C-terminal His tagged apPOL exonuclease mutant | | 分子名称: | MAGNESIUM ION, Prex DNA polymerase | | 著者 | Milton, M.E, Honzatko, R.B, Choe, J.Y, Nelson, S.W. | | 登録日 | 2015-09-04 | | 公開日 | 2016-08-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal Structure of the Apicoplast DNA Polymerase from Plasmodium falciparum: The First Look at a Plastidic A-Family DNA Polymerase.
J.Mol.Biol., 428, 2016
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5DKT
 | | N-terminal His tagged apPOL exonuclease mutant | | 分子名称: | Prex DNA polymerase, SODIUM ION, SULFATE ION | | 著者 | Milton, M.E, Honzatko, R.B, Choe, J.Y, Nelson, S.W. | | 登録日 | 2015-09-04 | | 公開日 | 2016-08-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal Structure of the Apicoplast DNA Polymerase from Plasmodium falciparum: The First Look at a Plastidic A-Family DNA Polymerase.
J.Mol.Biol., 428, 2016
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5NKL
 | | Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in a closed ternary complex with the artificial base pair dDs-dPxTP | | 分子名称: | ACETATE ION, DNA (5'-D(*AP*AP*AP*(DNU)P*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ... | | 著者 | Betz, K, Marx, A, Diederichs, K, Hirao, I, Kimoto, M. | | 登録日 | 2017-03-31 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair.
Angew. Chem. Int. Ed. Engl., 56, 2017
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5E41
 | | Crystal structure of the large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with 5-(N-(10-hydroxydecanoyl)-aminopentenyl)-2'-deoxyuridine-triphosphate | | 分子名称: | 2'-deoxy-5-{(1E)-5-[(10-hydroxydecanoyl)amino]pent-1-en-1-yl}uridine 5'-(tetrahydrogen triphosphate), DNA (5'-D(*AP*AP*AP*AP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ... | | 著者 | Hottin, A, Betz, K, Marx, A. | | 登録日 | 2015-10-05 | | 公開日 | 2016-12-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Basis for the KlenTaq DNA Polymerase Catalysed Incorporation of Alkene- versus Alkyne-Modified Nucleotides.
Chemistry, 23, 2017
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5O7T
 | | Crystal structure of KlenTaq mutant M747K in a closed ternary complex with a dG:dCTP base pair | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA polymerase I, thermostable, ... | | 著者 | Betz, K, Diederichs, K, Marx, A. | | 登録日 | 2017-06-09 | | 公開日 | 2017-11-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase.
Chem. Commun. (Camb.), 53, 2017
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8OOY
 | | Pol I bound to extended and displaced DNA section - open conformation | | 分子名称: | DNA polymerase I, Displacing Primer, Extending Primer, ... | | 著者 | Botto, M, Borsellini, A, Lamers, M.H. | | 登録日 | 2023-04-06 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | A four-point molecular handover during Okazaki maturation.
Nat.Struct.Mol.Biol., 30, 2023
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8OO6
 | | Pol I bound to extended and displaced DNA section - closed conformation | | 分子名称: | DNA polymerase I, Displaced primer, Extending Primer, ... | | 著者 | Botto, M, Borsellini, A, Lamers, M.H. | | 登録日 | 2023-04-04 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | A four-point molecular handover during Okazaki maturation.
Nat.Struct.Mol.Biol., 30, 2023
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5OXJ
 | | Crystal structure of KlenTaq mutant M747K in a closed ternary complex with a O6-MeG:BenziTP base pair | | 分子名称: | ACETATE ION, DNA polymerase I, thermostable, ... | | 著者 | Betz, K, Diederichs, K, Marx, A. | | 登録日 | 2017-09-06 | | 公開日 | 2017-11-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase.
Chem. Commun. (Camb.), 53, 2017
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6Q4V
 | | KlenTaq DNA polymerase in complex with dATP | | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*CP*TP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... | | 著者 | Kropp, H.M, Diederichs, K, Marx, A. | | 登録日 | 2018-12-06 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | | 主引用文献 | The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.
Angew.Chem.Int.Ed.Engl., 58, 2019
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6Q4U
 | | KlenTaq DNA pol in a closed ternary complex with 7-deaza-7-(2-(2-hydroxyethoxy)-N-(prop-2-yn-1-yl)acetamide)-2-dATP | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*CP*TP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*(DOC))-3'), ... | | 著者 | Kropp, H.M, Diederichs, K, Marx, A. | | 登録日 | 2018-12-06 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.005 Å) | | 主引用文献 | The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.
Angew.Chem.Int.Ed.Engl., 58, 2019
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4XVM
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4XVI
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4XIU
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1BGX
 | | TAQ POLYMERASE IN COMPLEX WITH TP7, AN INHIBITORY FAB | | 分子名称: | TAQ DNA POLYMERASE, TP7 MAB | | 著者 | Murali, R, Sharkey, D.J, Daiss, J.L, Krishna Murthy, H.M. | | 登録日 | 1998-06-02 | | 公開日 | 1998-10-14 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of Taq DNA polymerase in complex with an inhibitory Fab: the Fab is directed against an intermediate in the helix-coil dynamics of the enzyme.
Proc.Natl.Acad.Sci.USA, 95, 1998
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3LWL
 | | Structure of Klenow fragment of Taq polymerase in complex with an abasic site | | 分子名称: | 2',3'-dideoxyadenosine triphosphate, ACETATE ION, DNA (5'-D(*AP*AP*AP*(3DR)P*TP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... | | 著者 | Marx, A, Diederichs, K, Obeid, S. | | 登録日 | 2010-02-24 | | 公開日 | 2010-05-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Replication through an abasic DNA lesion: structural basis for adenine selectivity
Embo J., 29, 2010
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4XVK
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4XVL
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3M8R
 | | Crystal structure of the large fragment of DNA polymerase I from Thermus aquaticus in a closed ternary complex with trapped 4'-ethylated dTTP | | 分子名称: | 4'-ethylthymidine 5'-(tetrahydrogen triphosphate), ACETATE ION, DNA (5'-D(*AP*AP*AP*AP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... | | 著者 | Diederichs, K, Marx, A, Betz, K. | | 登録日 | 2010-03-19 | | 公開日 | 2010-07-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structures of DNA polymerases caught processing size-augmented nucleotide probes.
Angew.Chem.Int.Ed.Engl., 49, 2010
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3M8S
 | | Crystal structure of the large fragment of DNA polymerase I from Thermus aquaticus in a closed ternary complex with trapped 4'-methylated dTTP | | 分子名称: | 4'-methylthymidine 5'-(tetrahydrogen triphosphate), ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Diederichs, K, Marx, A, Betz, K. | | 登録日 | 2010-03-19 | | 公開日 | 2010-07-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of DNA polymerases caught processing size-augmented nucleotide probes.
Angew.Chem.Int.Ed.Engl., 49, 2010
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1D9F
 | | CRYSTAL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH DNA TETRAMER CARRYING 2'-O-(3-AMINOPROPYL)-RNA MODIFICATION 5'-D(TT)-AP(U)-D(T)-3' | | 分子名称: | DNA POLYMERASE I, DNA/RNA (5'-D(*TP*TP)-R(*(U31)P)-D(*T)-3'), SULFATE ION, ... | | 著者 | Teplova, M, Wallace, S.T, Tereshko, V, Minasov, G, Simons, A.M, Cook, P.D, Manoharan, M, Egli, M. | | 登録日 | 1999-10-27 | | 公開日 | 1999-12-02 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proc.Natl.Acad.Sci.USA, 96, 1999
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1D9D
 | | CRYSTALL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH SHORT DNA FRAGMENT CARRYING 2'-0-AMINOPROPYL-RNA MODIFICATIONS 5'-D(TCG)-AP(AUC)-3' | | 分子名称: | 5'-D(*TP*CP*GP)-R(AP*(U31)P*(C31))-3', DNA POLYMERASE I, MAGNESIUM ION, ... | | 著者 | Teplova, M, Wallace, S.T, Tereshko, V, Minasov, G, Simons, A.M, Cook, P.D, Manoharan, M, Egli, M. | | 登録日 | 1999-10-27 | | 公開日 | 1999-12-02 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proc.Natl.Acad.Sci.USA, 96, 1999
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3OJU
 | | Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing c5 modified thymidies | | 分子名称: | 2'-deoxy-5-[(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)ethynyl]uridine 5'-(tetrahydrogen triphosphate), DNA (5'-D(*AP*AP*AP*AP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ... | | 著者 | Marx, A, Diederichs, K, Obeid, S. | | 登録日 | 2010-08-23 | | 公開日 | 2010-12-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1DPI
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