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PDB: 616 件
4IHL
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Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
分子名称: (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol, 14-3-3 protein zeta/delta, POTASSIUM ION, ...
著者Molzan, M, Ottmann, C.
登録日2012-12-19
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
4FL5
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BU of 4fl5 by Molmil
Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Schumacher, B, Ottmann, C.
登録日2012-06-14
公開日2013-12-11
最終更新日2017-06-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
FASEB J., 29, 2015
3P1P
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BU of 3p1p by Molmil
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide
分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ...
著者Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
登録日2010-09-30
公開日2011-10-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
3P1Q
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BU of 3p1q by Molmil
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 Peptide and stabilizer fusicoccin A
分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CALCIUM ION, ...
著者Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
登録日2010-09-30
公開日2011-10-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
3P1O
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BU of 3p1o by Molmil
Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilisator Fusicoccin A
分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CALCIUM ION, ...
著者Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
登録日2010-09-30
公開日2011-10-12
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
4IEA
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BU of 4iea by Molmil
14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide
分子名称: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase
著者Molzan, M, Ottmann, C.
登録日2012-12-13
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
3MHR
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BU of 3mhr by Molmil
14-3-3 sigma in complex with YAP pS127-peptide
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Schumacher, B, Skwarczynska, M, Rose, R, Ottmann, C.
登録日2010-04-08
公開日2010-09-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Structure of a 14-3-3[sigma]-YAP phosphopeptide complex at 1.15 A resolution
Acta Crystallogr.,Sect.F, 66, 2010
3P1N
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BU of 3p1n by Molmil
Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide
分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ...
著者Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C.
登録日2010-09-30
公開日2011-10-12
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
Chem. Biol., 20, 2013
3NKX
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BU of 3nkx by Molmil
Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
分子名称: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase
著者Schumacher, B, Weyand, M, Ottmann, C.
登録日2010-06-21
公開日2010-09-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling
Mol.Cell.Biol., 30, 2010
4JDD
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BU of 4jdd by Molmil
14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface
分子名称: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN
著者Bier, D, Ottmann, C.
登録日2013-02-25
公開日2013-05-15
最終更新日2017-06-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4JC3
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BU of 4jc3 by Molmil
14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface
分子名称: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION
著者Bier, D, Ottmann, C.
登録日2013-02-21
公開日2013-05-15
最終更新日2017-06-07
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
6A5Q
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BU of 6a5q by Molmil
Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif
分子名称: 14-3-3 protein beta/alpha, MALONIC ACID, TFEB pS211-peptide
著者Xu, Y, Ren, J.Q, Feng, W.
登録日2018-06-25
公開日2019-02-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
Autophagy, 15, 2019
6A5S
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BU of 6a5s by Molmil
Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif
分子名称: 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ...
著者Xu, Y, Ren, J.Q, Feng, W.
登録日2018-06-25
公開日2019-02-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
Autophagy, 15, 2019
6BCR
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BU of 6bcr by Molmil
Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T340
分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, ...
著者Kast, D.J, Dominguez, R.
登録日2017-10-20
公開日2018-10-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.986 Å)
主引用文献Mechanism of IRSp53 inhibition by 14-3-3.
Nat Commun, 10, 2019
6BD2
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BU of 6bd2 by Molmil
Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and S366
分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, ...
著者Kast, D.J, Dominguez, R.
登録日2017-10-20
公開日2018-10-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Mechanism of IRSp53 inhibition by 14-3-3.
Nat Commun, 10, 2019
6BD1
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BU of 6bd1 by Molmil
Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at S366
分子名称: 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, Insulin receptor substrate protein of 53 kDa, ...
著者Kast, D.J, Dominguez, R.
登録日2017-10-20
公開日2018-10-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Mechanism of IRSp53 inhibition by 14-3-3.
Nat Commun, 10, 2019
6BCY
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BU of 6bcy by Molmil
Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T360
分子名称: 14-3-3 protein theta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DI(HYDROXYETHYL)ETHER, ...
著者Kast, D.J, Dominguez, R.
登録日2017-10-20
公開日2018-10-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Mechanism of IRSp53 inhibition by 14-3-3.
Nat Commun, 10, 2019
6BYK
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BU of 6byk by Molmil
Structure of 14-3-3 beta/alpha bound to O-ClcNAc peptide
分子名称: 14-3-3 protein beta/alpha, 2-acetamido-2-deoxy-beta-D-glucopyranose, ATPPVSQASSTT O-GlcNac peptide
著者Schumacher, M.A.
登録日2017-12-20
公開日2018-05-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.
Proc.Natl.Acad.Sci.USA, 115, 2018
6BZD
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BU of 6bzd by Molmil
Structure of 14-3-3 gamma R57E mutant bound to GlcNAcylated peptide
分子名称: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, GlcNAcylated peptide
著者Schumacher, M.A.
登録日2017-12-22
公開日2018-05-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BYL
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BU of 6byl by Molmil
Structure of 14-3-3 gamma bound to O-GlcNAcylated thr peptide
分子名称: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSASTTVPVTTATTTTTSTW O-GlcNac peptide
著者Schumacher, M.A.
登録日2017-12-20
公開日2018-05-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.
Proc.Natl.Acad.Sci.USA, 115, 2018
6BYJ
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BU of 6byj by Molmil
Structure of human 14-3-3 gamma bound to O-GlcNAc peptide
分子名称: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSTTATPPVSQASSTTTSTW O-GlcNac peptide
著者Schumacher, M.A.
登録日2017-12-20
公開日2018-05-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.
Proc.Natl.Acad.Sci.USA, 115, 2018
6BQT
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BU of 6bqt by Molmil
Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and T360
分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
著者Kast, D.J, Dominguez, R.
登録日2017-11-28
公開日2018-12-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Mechanism of IRSp53 inhibition by 14-3-3.
Nat Commun, 10, 2019
3SMK
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BU of 3smk by Molmil
Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenin A
分子名称: 14-3-3 protein sigma, Cotylenin A, MAGNESIUM ION, ...
著者Anders, C, Schumacher, B, Ottmann, C.
登録日2011-06-28
公開日2012-07-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.
Chem. Biol., 20, 2013
3SMN
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BU of 3smn by Molmil
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin A-THF
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Anders, C, Schumacher, B, Ottmann, C.
登録日2011-06-28
公開日2012-07-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.
Chem. Biol., 20, 2013
3T0L
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BU of 3t0l by Molmil
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
分子名称: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ...
著者Thiel, P, Ottmann, C.
登録日2011-07-20
公開日2012-12-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
Chem.Commun.(Camb.), 49, 2013

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