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PDB: 515 件
2QA3
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Structural Studies Reveal the Inactivation of E. coli L-aspartate aminotransferase by (S)-4,5-amino-dihydro-2-thiophenecarboxylic acid (SADTA) via two mechanisms (at pH6.5)
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, Aspartate aminotransferase, ...
著者Liu, D, Pozharski, E, Lepore, B, Fu, M, Silverman, R.B, Petsko, G.A, Ringe, D.
登録日2007-06-14
公開日2007-12-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".
Biochemistry, 46, 2007
7V5I
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Structural insights into the substrate selectivity of acyl-CoA transferase
分子名称: 2-amino-3-ketobutyrate coenzyme A ligase, PYRIDOXAL-5'-PHOSPHATE
著者Chang, H.Y, Ko, T.P.
登録日2021-08-17
公開日2021-12-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Structural insights into the substrate selectivity of alpha-oxoamine synthases from marine Vibrio sp. QWI-06.
Colloids Surf B Biointerfaces, 210, 2022
7V58
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Structural insights into the substrate selectivity of acyl-CoA transferase
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-amino-3-ketobutyrate coenzyme A ligase, GLYCINE, ...
著者Chang, H.Y, Ko, T.P.
登録日2021-08-16
公開日2021-12-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structural insights into the substrate selectivity of alpha-oxoamine synthases from marine Vibrio sp. QWI-06.
Colloids Surf B Biointerfaces, 210, 2022
2R2N
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BU of 2r2n by Molmil
The crystal structure of human kynurenine aminotransferase II in complex with kynurenine
分子名称: (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ...
著者Han, Q, Robinson, H, Li, J.
登録日2007-08-27
公開日2007-12-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of human kynurenine aminotransferase II.
J.Biol.Chem., 283, 2008
7TUR
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BU of 7tur by Molmil
Joint X-ray/neutron structure of aspastate aminotransferase (AAT) in complex with pyridoxamine 5'-phosphate (PMP)
分子名称: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aspartate aminotransferase, ...
著者Drago, V.N, Kovalevsky, A.Y, Dajnowicz, S, Mueser, T.C.
登録日2022-02-03
公開日2022-09-28
最終更新日2023-10-25
実験手法NEUTRON DIFFRACTION (1.7 Å), X-RAY DIFFRACTION
主引用文献An N⋯H⋯N low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction.
Chem Sci, 13, 2022
8JUJ
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Crystal structures of Cystathionine beta lyase from Bacillus cereus ATCC 14579
分子名称: Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE
著者Yu, H, Kim, K.-J.
登録日2023-06-26
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Crystal structures of Cystathionine beta lyase from Bacillus cereus ATCC 14579
To Be Published
5YHV
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BU of 5yhv by Molmil
Crystal structure of an aminotransferase from Mycobacterium tuberculosis
分子名称: 2-OXOGLUTARIC ACID, Aminotransferase, GLUTAMIC ACID, ...
著者Saroj, D.C, Biswal, B.K.
登録日2017-09-30
公開日2018-10-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of an aminotransferase from Mycobacterium tuberculosis
To Be Published
8KDL
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BU of 8kdl by Molmil
Crystal structure of LmbF in complex with PLP
分子名称: Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme, GLYCEROL
著者Mori, T, Lyu, S, Kadlcik, S, Abe, I.
登録日2023-08-09
公開日2024-08-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of LmbF in complex with PLP
To Be Published
8KDK
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Crystal structure of CcbF in complex with PLP
分子名称: CcbF
著者Mori, T, Lyu, S, Kadlcik, S, Abe, I.
登録日2023-08-09
公開日2024-08-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of CcbF in complex with PLP
To Be Published
8SKR
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human liver mitochondrial Aspartate aminotransferase
分子名称: Aspartate aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE
著者Zhang, Z, Tringides, M.
登録日2023-04-20
公開日2024-02-21
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Mol.Cell Proteomics, 22, 2023
5WML
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Arabidopsis thaliana Prephenate Aminotransferase mutant- K306A
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase, GLUTAMIC ACID
著者Jez, J.M, Holland, C.K.
登録日2017-07-29
公開日2018-08-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.103 Å)
主引用文献Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis.
Plant J., 94, 2018
5Z0Q
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Crystal Structure of OvoB
分子名称: Aminotransferase, class I and II, PYRIDOXAL-5'-PHOSPHATE
著者Cai, Y.J, Huang, P, Wu, L, Zhou, J.H, Liu, P.H.
登録日2017-12-20
公開日2018-11-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions.
Org. Lett., 20, 2018
7VRX
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Pad-1 in the absence of substrate
分子名称: Aminotransferase, SULFATE ION
著者Choi, M, Rhee, S.
登録日2021-10-25
公開日2022-04-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.96634674 Å)
主引用文献Structural and biochemical basis for the substrate specificity of Pad-1, an indole-3-pyruvic acid aminotransferase in auxin homeostasis.
J.Struct.Biol., 214, 2022
8QOG
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BU of 8qog by Molmil
Cryo-EM structure of the yeast SPT-Orm2-Monomer complex
分子名称: 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ORM2 isoform 1, PYRIDOXAL-5'-PHOSPHATE, ...
著者Schaefer, J, Koerner, C, Moeller, A, Froehlich, F.
登録日2023-09-28
公開日2024-09-04
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins.
Cell Rep, 43, 2024
8QOF
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Cryo-EM structure of the yeast SPT-Orm2-Dimer complex
分子名称: 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ORM2 isoform 1, PYRIDOXAL-5'-PHOSPHATE, ...
著者Schaefer, J, Koerner, C, Moeller, A, Froehlich, F.
登録日2023-09-28
公開日2024-09-04
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins.
Cell Rep, 43, 2024
5WMI
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Arabidopsis thaliana Prephenate Aminotransferase mutant- T84V
分子名称: 2-OXOGLUTARIC ACID, Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
著者Jez, J.M, Holland, C.K.
登録日2017-07-28
公開日2018-08-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis.
Plant J., 94, 2018
8TN3
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Structure of S. hygroscopicus aminotransferase MppQ complexed with pyridoxamine 5'-phosphate (PMP)
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, PLP-dependent aminotransferase MppQ
著者Silvaggi, N.R, Vuksanovic, N.
登録日2023-08-01
公開日2023-11-22
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structural and Biochemical Characterization of MppQ, an L-Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus.
Biochemistry, 62, 2023
8TN2
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Structure of S. hygroscopicus aminotransferase MppQ complexed with pyridoxal-5'-phosphate (PLP)
分子名称: PLP-dependent aminotransferase MppQ
著者Silvaggi, N.R, Vuksanovic, N.
登録日2023-08-01
公開日2023-11-22
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and Biochemical Characterization of MppQ, an L-Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus.
Biochemistry, 62, 2023
5X03
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Crystal structure of the C-terminal domain of Bacillus subtilis GabR reveals a closed conformation by the binding of gamma-aminobutyric acid, inducing the transcriptional activation
分子名称: GAMMA-AMINO-BUTANOIC ACID, HTH-type transcriptional regulatory protein GabR, PYRIDOXAL-5'-PHOSPHATE
著者Park, S.A, Lee, K.S.
登録日2017-01-19
公開日2017-05-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the C-terminal domain of Bacillus subtilis GabR reveals a closed conformation by gamma-aminobutyric acid binding, inducing transcriptional activation
Biochem. Biophys. Res. Commun., 487, 2017
5AX8
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Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase
分子名称: Aspartate aminotransferase, mitochondrial
著者Jiang, X, Wang, J, Chang, H, Zhou, Y.
登録日2015-07-20
公開日2016-03-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.989 Å)
主引用文献Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase
Biosci Trends, 10, 2016
5BK7
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The structure of MppP E15A mutant soaked with the substrate L-arginine
分子名称: (E)-N~2~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-arginine, PLP-Dependent L-Arginine Hydroxylase MppP
著者Han, L, Silvaggi, N.R.
登録日2018-01-27
公開日2018-09-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.196 Å)
主引用文献Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase.
Biochemistry, 57, 2018
1OXP
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ASPARTATE AMINOTRANSFERASE, H-ASP COMPLEX, CLOSED CONFORMATION
分子名称: 4'-DEOXY-4'-ACETYLYAMINO-PYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE
著者Hohenester, E, Schirmer, T, Jansonius, J.N.
登録日1995-12-23
公開日1996-06-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase.
Eur.J.Biochem., 236, 1996
5BJ4
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THERMUS THERMOPHILUS ASPARTATE AMINOTRANSFERASE TETRA MUTANT 2
分子名称: PHOSPHATE ION, PROTEIN (ASPARTATE AMINOTRANSFERASE), PYRIDOXAL-5'-PHOSPHATE
著者Ura, H, Nakai, T, Kawaguchi, S.I, Miyahara, I, Hirotsu, K, Kuramitsu, S.
登録日1999-01-11
公開日2003-09-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Substrate recognition mechanism of thermophilic dual-substrate enzyme
J.BIOCHEM.(TOKYO), 130, 2001
1OXO
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ASPARTATE AMINOTRANSFERASE, H-ASP COMPLEX, OPEN CONFORMATION
分子名称: 4'-DEOXY-4'-ACETYLYAMINO-PYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE
著者Hohenester, E, Schirmer, T, Jansonius, J.N.
登録日1995-12-23
公開日1996-06-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase.
Eur.J.Biochem., 236, 1996
8WKJ
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The crystal structure of aspartate aminotransferases Lpg0070 from Legionella pneumophila
分子名称: Aminotransferase, PYRIDOXAL-5'-PHOSPHATE
著者Gao, Y.S, Hua, L, Xie, R.
登録日2023-09-27
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of an aspartate aminotransferase Lpg0070 from Legionella pneumophila.
Biochem.Biophys.Res.Commun., 689, 2023

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