5DJ1
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6JPK
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1QIR
| ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI, C191Y MUTATION, WITH BOUND MALEATE | 分子名称: | ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE | 著者 | Jeffery, C.J, Gloss, L.M, Petsko, G.A, Ringe, D. | 登録日 | 1999-06-15 | 公開日 | 2000-06-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Role of Residues Outside the Active Site in Catalysis: Structural Basis for Function of C191 Mutants of E. Coli Aspartate Aminotransferase Protein Eng., 13, 2000
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5EFS
| The crystal structure of human kynurenine aminotransferase II | 分子名称: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 著者 | Nematollahi, A, Sun, G, Kwan, A, Harrop, S.J, Hanrahan, J.R, Nadvi, N.A, Church, W.B. | 登録日 | 2015-10-26 | 公開日 | 2015-11-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.82503 Å) | 主引用文献 | The crystal structure of human kynurenine aminotransferase II To Be Published
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7RF9
| O2-, PLP-dependent desaturase Plu4 intermediate-bound enzyme | 分子名称: | (2E)-5-carbamimidamido-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}pentanoic acid, 1,2-ETHANEDIOL, 2-(2-ETHOXYETHOXY)ETHANOL, ... | 著者 | Hoffarth, E.R, Ryan, K.S. | 登録日 | 2021-07-13 | 公開日 | 2021-10-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.926 Å) | 主引用文献 | A shared mechanistic pathway for pyridoxal phosphate-dependent arginine oxidases. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S5M
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6HNB
| Crystal structure of aminotransferase Aro8 from Candida albicans | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Aromatic amino acid aminotransferase I, CHLORIDE ION, ... | 著者 | Kiliszek, A, Rzad, K, Rypniewski, W, Milewski, S, Gabriel, I. | 登録日 | 2018-09-14 | 公開日 | 2019-02-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties. J.Struct.Biol., 205, 2019
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1QIT
| ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI, C191W MUTATION, WITH BOUND MALEATE | 分子名称: | ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE | 著者 | Jeffery, C.J, Gloss, L.M, Petsko, G.A, Ringe, D. | 登録日 | 1999-06-15 | 公開日 | 2000-06-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Role of Residues Outside the Active Site in Catalysis: Structural Basis for Function of C191 Mutants of E. Coli Aspartate Aminotransferase Protein Eng., 13, 2000
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6HND
| Crystal structure of the aromatic aminotransferase Aro9 from C. Albicans | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Aromatic-amino-acid:2-oxoglutarate transaminase, POTASSIUM ION, ... | 著者 | Kiliszek, A, Rzad, K, Rypniewski, W, Milewski, S, Gabriel, I. | 登録日 | 2018-09-14 | 公開日 | 2019-02-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties. J.Struct.Biol., 205, 2019
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6HNV
| Crystal structure of aminotransferase Aro9 from C. Albicans with ligands | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINOHEXANEDIOIC ACID, 2-OXOADIPIC ACID, ... | 著者 | Kiliszek, A, Rzad, K, Rypniewski, W, Milewski, S, Gabriel, I. | 登録日 | 2018-09-17 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties. J.Struct.Biol., 205, 2019
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6HRH
| Structure of human erythroid-specific 5'-aminolevulinate synthase, ALAS2 | 分子名称: | 5-aminolevulinate synthase, erythroid-specific, mitochondrial, ... | 著者 | Bailey, H.J, Shrestha, L, Rembeza, E, Newman, J, Kupinska, K, Diaz-saez, L, Kennedy, E, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W, Structural Genomics Consortium (SGC) | 登録日 | 2018-09-27 | 公開日 | 2018-11-07 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of human erythroid-specific 5'-aminolevulinate synthase, ALAS2 To Be Published
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1QIS
| ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI, C191F MUTATION, WITH BOUND MALEATE | 分子名称: | ASPARTATE AMINOTRANSFERASE, MALEIC ACID, PYRIDOXAL-5'-PHOSPHATE | 著者 | Jeffery, C.J, Gloss, L.M, Petsko, G.A, Ringe, D. | 登録日 | 1999-06-15 | 公開日 | 2000-06-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Role of Residues Outside the Active Site in Catalysis: Structural Basis for Function of C191 Mutants of E. Coli Aspartate Aminotransferase Protein Eng., 13, 2000
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5EAA
| ASPARTATE AMINOTRANSFERASE FROM E. COLI, C191S MUTATION | 分子名称: | ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Jeffery, C.J, Gloss, L.M, Petsko, G.A, Ringe, D. | 登録日 | 1998-12-29 | 公開日 | 2000-10-27 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The role of residues outside the active site: structural basis for function of C191 mutants of Escherichia coli aspartate aminotransferase. Protein Eng., 13, 2000
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6HNU
| Crystal structure of the aminotransferase Aro8 from C. Albicans with ligands | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Aromatic amino acid aminotransferase I, ... | 著者 | Kiliszek, A, Rzad, K, Rypniewski, W, Milewski, S, Gabriel, I. | 登録日 | 2018-09-17 | 公開日 | 2019-02-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties. J.Struct.Biol., 205, 2019
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5EUN
| The Crystal Structure of Human Kynurenine Aminotransferase II, PLP-bound form, at 1.83 A | 分子名称: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 著者 | Nematollahi, A, Sun, G, Kwan, A, Jeffries, C.M, Harrop, S.J, Hanrahan, J.R, Nadvi, N.A, Church, W.B. | 登録日 | 2015-11-18 | 公開日 | 2015-12-16 | 最終更新日 | 2016-08-10 | 実験手法 | X-RAY DIFFRACTION (1.825 Å) | 主引用文献 | Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 angstrom Resolution. Int J Mol Sci, 17, 2016
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1OXO
| ASPARTATE AMINOTRANSFERASE, H-ASP COMPLEX, OPEN CONFORMATION | 分子名称: | 4'-DEOXY-4'-ACETYLYAMINO-PYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE | 著者 | Hohenester, E, Schirmer, T, Jansonius, J.N. | 登録日 | 1995-12-23 | 公開日 | 1996-06-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase. Eur.J.Biochem., 236, 1996
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3UE8
| Kynurenine Aminotransferase II Inhibitors | 分子名称: | (5-hydroxy-4-{[(1-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, CHLORIDE ION, Kynurenine/alpha-aminoadipate aminotransferase, ... | 著者 | Dounay, A.B, Anderson, M, Bechle, B.M, Campbell, B.M, Claffey, M.M, Evdokimov, A, Edelweiss, E, Fonseca, K.R, Gan, X, Ghosh, S, Hayward, M.M, Horner, W, Kim, J.Y, McAllister, L.A, Pandit, J, Paradis, V, Parikh, V.D, Reese, M.R, Rong, S.B, Salafia, M.A, Schuyten, K, Strick, C.A, Tuttle, J.B, Valentine, J, Wang, H, Zawadzke, L.E, Verhoest, P.R. | 登録日 | 2011-10-28 | 公開日 | 2012-02-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett, 3, 2012
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4GEB
| Kynurenine Aminotransferase II Inhibitors | 分子名称: | (5-hydroxy-4-{[(7-hydroxy-6-oxo-2-phenyl-6,7-dihydro-2H-pyrazolo[3,4-b]pyridin-5-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, ... | 著者 | Pandit, J. | 登録日 | 2012-08-01 | 公開日 | 2013-03-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency. Bioorg.Med.Chem.Lett., 23, 2013
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4GE7
| Kynurenine Aminotransferase II Inhibitors | 分子名称: | (5-hydroxy-4-{[(1-hydroxy-2-oxo-6-phenoxy-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 著者 | Pandit, J. | 登録日 | 2012-08-01 | 公開日 | 2012-11-07 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett, 4, 2013
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4GE4
| Kynurenine Aminotransferase II Inhibitors | 分子名称: | (5-hydroxy-4-{[(1-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 著者 | Pandit, J. | 登録日 | 2012-08-01 | 公開日 | 2012-11-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett, 4, 2013
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4GDY
| Kynurenine Aminotransferase II inhibitors | 分子名称: | (5-hydroxy-6-methyl-4-{[(1-oxo-7-phenoxy-1,2-dihydro[1,2,4]triazolo[4,3-a]quinolin-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 著者 | Pandit, J. | 登録日 | 2012-08-01 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Discovery of Hydroxamate Bioisosteres as KATII Inhibitors with Improved Oral Bioavailability and Pharmacokinetics MEDCHEMCOMM, 2012
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4GE9
| Kynurenine Aminotransferase II Inhibitors | 分子名称: | (4-{[(6-benzyl-1-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 著者 | Pandit, J. | 登録日 | 2012-08-01 | 公開日 | 2012-11-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett, 4, 2013
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4H51
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8GUH
| Serine Palmitoyltransferase from Sphingobacterium multivorum complexed with Tris | 分子名称: | 1,2-ETHANEDIOL, Serine palmitoyltransferase, [4-[[[2-(hydroxymethyl)-1,3-bis(oxidanyl)propan-2-yl]amino]methyl]-6-methyl-5-oxidanyl-pyridin-3-yl]methyl dihydrogen phosphate | 著者 | Murakami, T, Takahashi, A, Katayama, A, Miyahara, I, Kamiya, N, Ikushiro, H, Yano, T. | 登録日 | 2022-09-12 | 公開日 | 2023-07-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structure of Sphingobacterium multivorum serine palmitoyltransferase complexed with tris(hydroxymethyl)aminomethane. Acta Crystallogr.,Sect.F, 78, 2022
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8H1Q
| Serine Palmitoyltransferase from Sphingobacterium multivorum complexed with L-serine | 分子名称: | 1,2-ETHANEDIOL, Serine palmitoyltransferase, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE | 著者 | Murakami, T, Takahashi, A, Katayama, A, Miyahara, I, Kamiya, N, Ikushiro, H, Yano, T. | 登録日 | 2022-10-03 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural insights into the substrate recognition of serine palmitoyltransferase from Sphingobacterium multivorum. J.Biol.Chem., 299, 2023
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