8BUL
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![BU of 8bul by Molmil](/molmil-images/mine/8bul) | Structure of DDB1 bound to DS11-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BU5
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![BU of 8bu5 by Molmil](/molmil-images/mine/8bu5) | Structure of DDB1 bound to SR-4835-engaged CDK12-cyclin K | 分子名称: | CITRIC ACID, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.134 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUS
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![BU of 8bus by Molmil](/molmil-images/mine/8bus) | Structure of DDB1 bound to DS59-engaged CDK12-cyclin K | 分子名称: | 1,3-dimethyl-5-[[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]methyl]pyrazole-4-sulfonamide, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUH
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![BU of 8buh by Molmil](/molmil-images/mine/8buh) | Structure of DDB1 bound to WX3-engaged CDK12-cyclin K | 分子名称: | 6-[[[2-[[(2~{R})-1-oxidanylbutan-2-yl]amino]-9-propan-2-yl-purin-6-yl]amino]methyl]-3-pyridin-2-yl-1~{H}-pyridin-2-one, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.79 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUC
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![BU of 8buc by Molmil](/molmil-images/mine/8buc) | Structure of DDB1 bound to dCeMM3-engaged CDK12-cyclin K | 分子名称: | 2-(1~{H}-benzimidazol-2-ylsulfanyl)-~{N}-(5-chloranylpyridin-2-yl)ethanamide, CITRIC ACID, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.85 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUT
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![BU of 8but by Molmil](/molmil-images/mine/8but) | Structure of DDB1 bound to DS61-engaged CDK12-cyclin K | 分子名称: | 2-[[6-[[4-(2-hydroxyethyloxy)phenyl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUD
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![BU of 8bud by Molmil](/molmil-images/mine/8bud) | Structure of DDB1 bound to Z7-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUE
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![BU of 8bue by Molmil](/molmil-images/mine/8bue) | Structure of DDB1 bound to Z11-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUG
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![BU of 8bug by Molmil](/molmil-images/mine/8bug) | Structure of DDB1 bound to HQ461-engaged CDK12-cyclin K | 分子名称: | 2-[2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-~{N}-(5-methyl-1,3-thiazol-2-yl)ethanamide, CITRIC ACID, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BZO
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![BU of 8bzo by Molmil](/molmil-images/mine/8bzo) | Cryo-EM structure of CDK2-CyclinA in complex with p27 from the SCFSKP2 E3 ligase Complex | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B | 著者 | Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E. | 登録日 | 2022-12-15 | 公開日 | 2023-06-28 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1. Sci Rep, 13, 2023
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8BYQ
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![BU of 8byq by Molmil](/molmil-images/mine/8byq) | RNA polymerase II pre-initiation complex with the proximal +1 nucleosome (PIC-Nuc10W) | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Abril-Garrido, J, Dienemann, C, Grabbe, F, Velychko, T, Lidschreiber, M, Wang, H, Cramer, P. | 登録日 | 2022-12-14 | 公開日 | 2023-05-03 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis of transcription reduction by a promoter-proximal +1 nucleosome. Mol.Cell, 83, 2023
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8BUM
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![BU of 8bum by Molmil](/molmil-images/mine/8bum) | Structure of DDB1 bound to DS15-engaged CDK12-cyclin K | 分子名称: | (2R)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-20 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BU7
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![BU of 8bu7 by Molmil](/molmil-images/mine/8bu7) | Structure of DDB1 bound to 21195-engaged CDK12-cyclin K | 分子名称: | 1,2-ETHANEDIOL, 1-[2,6-bis(chloranyl)phenyl]-6-[[4-(2-hydroxyethyloxy)phenyl]methyl]-3-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.245 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUN
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![BU of 8bun by Molmil](/molmil-images/mine/8bun) | Structure of DDB1 bound to DS16-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BU2
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![BU of 8bu2 by Molmil](/molmil-images/mine/8bu2) | Structure of DDB1 bound to DS18-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUI
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![BU of 8bui by Molmil](/molmil-images/mine/8bui) | Structure of DDB1 bound to DRF-053-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)amino]purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUA
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![BU of 8bua by Molmil](/molmil-images/mine/8bua) | Structure of DDB1 bound to 919278-engaged CDK12-cyclin K | 分子名称: | (2~{R})-~{N}-(1~{H}-benzimidazol-2-yl)-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanamide, CITRIC ACID, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.193 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUR
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![BU of 8bur by Molmil](/molmil-images/mine/8bur) | Structure of DDB1 bound to DS50-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.64 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BU4
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![BU of 8bu4 by Molmil](/molmil-images/mine/8bu4) | Structure of DDB1 bound to DS22-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8B54
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![BU of 8b54 by Molmil](/molmil-images/mine/8b54) | CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768 | 分子名称: | 1,2-ETHANEDIOL, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Djukic, S, Skerlova, J, Rezacova, P. | 登録日 | 2022-09-21 | 公開日 | 2023-03-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7. Biomed Pharmacother, 161, 2023
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8BVW
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![BU of 8bvw by Molmil](/molmil-images/mine/8bvw) | RNA polymerase II pre-initiation complex with the distal +1 nucleosome (PIC-Nuc18W) | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Abril-Garrido, J, Dienemann, C, Grabbe, F, Velychko, T, Lidschreiber, M, Wang, H, Cramer, P. | 登録日 | 2022-12-20 | 公開日 | 2023-05-03 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of transcription reduction by a promoter-proximal +1 nucleosome. Mol.Cell, 83, 2023
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4CXA
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![BU of 4cxa by Molmil](/molmil-images/mine/4cxa) | Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP | 分子名称: | CYCLIN-DEPENDENT KINASE 12, CYCLIN-K, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Dixon Clarke, S.E, Elkins, J.M, Pike, A.C.W, Nowak, R, Goubin, S, Mahajan, R.P, Kopec, J, Froese, S, Tallant, C, Carpenter, E.P, Mackenzie, A, Faust, B, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A.M, Bountra, C, Bullock, A. | 登録日 | 2014-04-04 | 公開日 | 2014-05-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structures of the Cdk12/Cyck Complex with AMP-Pnp Reveal a Flexible C-Terminal Kinase Extension Important for ATP Binding. Sci.Rep., 5, 2015
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4CRL
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![BU of 4crl by Molmil](/molmil-images/mine/4crl) | |
4BCG
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![BU of 4bcg by Molmil](/molmil-images/mine/4bcg) | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor | 分子名称: | 2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1, ... | 著者 | Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M. | 登録日 | 2012-10-02 | 公開日 | 2013-04-17 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (3.085 Å) | 主引用文献 | Substituted 4-(Thiazol-5-Yl)-2-(Phenylamino)Pyrimidines are Highly Active Cdk9 Inhibitors: Synthesis, X-Ray Crystal Structure, Sar and Anti-Cancer Activities. J.Med.Chem., 56, 2013
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4BCO
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![BU of 4bco by Molmil](/molmil-images/mine/4bco) | Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor | 分子名称: | 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ... | 著者 | Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M. | 登録日 | 2012-10-02 | 公開日 | 2013-01-09 | 最終更新日 | 2013-02-27 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity. J.Med.Chem., 56, 2013
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