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PDB: 1328 件
1MH1
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SMALL G-PROTEIN
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAC1
著者Hirshberg, M, Stockley, R.W, Dodson, G, Webb, M.R.
登録日1997-01-21
公開日1998-01-21
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.
Nat.Struct.Biol., 4, 1997
5P21
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REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS
分子名称: C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Pai, E.F, Wittinghofer, A, Kabsch, W.
登録日1990-04-30
公開日1992-01-15
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
EMBO J., 9, 1990
8VM2
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Crystal Structure of NRAS Q61K bound to GTP
分子名称: GTPase NRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Gebregiworgis, T, Chan, J.Y.L, Kuntz, D.A, Prive, G.G, Marshall, C.B, Ikura, M.
登録日2024-01-12
公開日2024-05-01
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.
Eur J Cell Biol, 103, 2024
2RGD
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Crystal structure of H-RasQ61L-GppNHp
分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
著者Buhrman, G, Wink, G, Mattos, C.
登録日2007-10-03
公開日2007-12-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf.
Structure, 15, 2007
8X6R
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BU of 8x6r by Molmil
KRasG12C in complex with inhibitor
分子名称: 1-[7-[6-ethenyl-8-ethoxy-7-(5-methyl-1~{H}-indazol-4-yl)-2-(1-methylpiperidin-4-yl)oxy-quinazolin-4-yl]-2,7-diazaspiro[3.5]nonan-2-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ...
著者Amano, Y, Tateishi, Y.
登録日2023-11-21
公開日2024-01-17
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors.
Bioorg.Med.Chem., 98, 2023
8CNN
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BU of 8cnn by Molmil
BeF3 Phospho-HRas GSA complex
分子名称: ACETATE ION, BERYLLIUM TRIFLUORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Baumann, P, Jin, Y.
登録日2023-02-23
公開日2023-09-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Far-reaching effects of tyrosine64 phosphorylation on Ras revealed with BeF 3 - complexes.
Commun Chem, 7, 2024
8CNJ
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HRas(1-166) in complex with GDP and BeF3-
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, BERYLLIUM TRIFLUORIDE ION, GTPase HRas, ...
著者Baumann, P, Jin, Y.
登録日2023-02-23
公開日2023-09-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Far-reaching effects of tyrosine64 phosphorylation on Ras revealed with BeF 3 - complexes.
Commun Chem, 7, 2024
3BWD
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Crystal structure of the plant Rho protein ROP5
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rac-like GTP-binding protein ARAC6
著者Thomas, C, Berken, A.
登録日2008-01-09
公開日2008-03-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Crystal structure of the plant Rho protein ROP5
To be Published
3C5C
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Crystal structure of human Ras-like, family 12 protein in complex with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-like protein 12, ...
著者Shen, L, Tong, Y, Tempel, W, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2008-01-31
公開日2008-02-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of human Ras-like, family 12 protein in complex with GDP.
To be Published
3CBQ
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Crystal structure of the human REM2 GTPase with bound GDP
分子名称: 1,2-ETHANEDIOL, GTP-binding protein REM 2, GUANOSINE-5'-DIPHOSPHATE, ...
著者Nedyalkova, L, Shen, Y, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2008-02-22
公開日2008-03-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Crystal structure of the human REM2 GTPase with bound GDP.
To be Published
6KX3
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Crystal structure of RhoA protein with covalent inhibitor DC-Rhoin
分子名称: GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA, prop-2-enyl (3R)-1,1-bis(oxidanylidene)-2,3-dihydro-1-benzothiophene-3-carboxylate
著者Zhang, H, Luo, C.
登録日2019-09-09
公開日2020-08-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.981 Å)
主引用文献Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.
Adv Sci, 7, 2020
6KX2
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Crystal structure of GDP bound RhoA protein
分子名称: GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA
著者Zhang, H, Luo, C.
登録日2019-09-09
公開日2020-08-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.454 Å)
主引用文献Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.
Adv Sci, 7, 2020
5WHE
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KRas G12V/D38P, bound to GppNHp and miniprotein 225-11
分子名称: CALCIUM ION, GTPase KRas, MAGNESIUM ION, ...
著者Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L.
登録日2017-07-16
公開日2018-01-03
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
4EPX
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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Sun, Q, Burke, J.P, Phan, J, Burns, M.C, Olejniczak, E.T, Waterson, A.G, Lee, T, Rossanese, O.W, Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
7O70
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KRasG12C ligand complex
分子名称: 1-[(4R,7S)-12-chloro-14-fluoro-13-(2-fluoro-6-hydroxyphenyl)-4-methyl-10-oxa-2,5,16,18-tetrazatetracyclo[9.7.1.0^(2,7).0^(15,19)]nonadeca-1(18),11,13,15(19),16-pentaen-5-en-1-one-yl]prop-2, CALCIUM ION, GTPase KRas, ...
著者Phillips, C.
登録日2021-04-12
公開日2022-04-20
最終更新日2022-05-25
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C .
J.Med.Chem., 65, 2022
5X9S
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BU of 5x9s by Molmil
Crystal structure of fully modified H-Ras-GppNHp
分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
著者Matsumoto, S, Ke, H, Murashima, Y, Taniguchi-Tamura, H, Miyamoto, R, Yoshikawa, Y, Kumasaka, T, Mizohata, E, Edamatsu, H, Kataoka, T.
登録日2017-03-09
公開日2017-08-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for intramolecular interaction of post-translationally modified H-RasGTP prepared by protein ligation
FEBS Lett., 591, 2017
5XC5
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BU of 5xc5 by Molmil
Crystal structure of Acanthamoeba polyphaga mimivirus Rab GTPase in complex with GTP
分子名称: ACETATE ION, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Ku, B, You, J.A, Kim, S.J.
登録日2017-03-22
公開日2017-10-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.398 Å)
主引用文献Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase
Arch. Virol., 162, 2017
6L6O
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Crystal structure of stabilized Rab5a GTPase domain from Leishmania donovani
分子名称: ACETATE ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
著者Arora, A, Zohib, M, Biswal, B.K, Maheshwari, D, Pal, R.K.
登録日2019-10-29
公開日2020-11-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the GDP-bound GTPase domain of Rab5a from Leishmania donovani.
Acta Crystallogr.,Sect.F, 76, 2020
5XR4
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Crystal structure of RabA1a in complex with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein RABA1a, ...
著者Yun, J.S, Chang, J.H.
登録日2017-06-07
公開日2018-06-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure and subcellular localization of RabA1a from Arabidopsis thaliana
To Be Published
4XVQ
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H-Ras Y137E
分子名称: GLYCEROL, GTPase HRas, MAGNESIUM ION, ...
著者Johnson, C.W, Mattos, C.
登録日2015-01-27
公開日2015-06-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.887 Å)
主引用文献Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.
Faseb J., 29, 2015
7OO7
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KRasG12C ligand complex
分子名称: 1-[(6aS)-3-chloro-2-(5-methyl-1H-indazol-4-yl)-5,6,6a,7,9,10-hexahydro-8H-pyrazino[1',2':5,6][1,5]oxazocino[4,3,2-de]quinazolin-8-yl]-2-propen-1-one, CALCIUM ION, GTPase KRas, ...
著者Phillips, C.
登録日2021-05-26
公開日2022-04-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C .
J.Med.Chem., 65, 2022
5KYK
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Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs
分子名称: 5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine, GTPase KRas
著者Xiong, Y, Lu, J, Hunter, J, Li, L, Scott, D, Manandhar, A, Gondi, S, Westover, K.D, Gray, N.S.
登録日2016-07-21
公開日2017-04-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.702 Å)
主引用文献Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
ACS Med Chem Lett, 8, 2017
5LEF
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Rab6A:Kif20A complex
分子名称: GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ISOPROPYL ALCOHOL, ...
著者Bressanelli, G, Pylypenko, O, Houdusse, A.
登録日2016-06-29
公開日2017-11-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.088 Å)
主引用文献Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions.
Nat Commun, 8, 2017
4RKE
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Drosophila melanogaster Rab2 bound to GMPPNP
分子名称: GH01619p, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ...
著者Lardong, J.A, Driller, J.H, Depner, H, Weise, C, Petzoldt, A, Wahl, M.C, Sigrist, S.J, Loll, B.
登録日2014-10-13
公開日2014-12-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.0006 Å)
主引用文献Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.
Acta Crystallogr F Struct Biol Commun, 71, 2015
3KKM
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Crystal structure of H-Ras T35S in complex with GppNHp
分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T.
登録日2009-11-06
公開日2010-06-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010

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