7KVJ
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![BU of 7kvj by Molmil](/molmil-images/mine/7kvj) | Human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-{[(2S)-1-oxo-3-phenyl-1-{[3-(pyridin-3-yl)propyl]amino}propan-2-yl]sulfanyl}-3-phenylpropan-2-yl]carbamate | 著者 | Sevrioukova, I. | 登録日 | 2020-11-28 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength. Int J Mol Sci, 22, 2021
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7KVQ
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![BU of 7kvq by Molmil](/molmil-images/mine/7kvq) | Human CYP3A4 bound to an inhibitor | 分子名称: | 1,2-ETHANEDIOL, Cytochrome P450 3A4, GLYCEROL, ... | 著者 | Sevrioukova, I. | 登録日 | 2020-11-28 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength. Int J Mol Sci, 22, 2021
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7KVS
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![BU of 7kvs by Molmil](/molmil-images/mine/7kvs) | Human CYP3A4 bound to an inhibitor | 分子名称: | 1,2-ETHANEDIOL, Cytochrome P450 3A4, GLYCEROL, ... | 著者 | Sevrioukova, I. | 登録日 | 2020-11-28 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength. Int J Mol Sci, 22, 2021
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7KVN
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![BU of 7kvn by Molmil](/molmil-images/mine/7kvn) | Human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-(1H-indol-3-yl)-3-{[(2R)-1-oxo-3-phenyl-1-{[3-(pyridin-3-yl)propyl]amino}propan-2-yl]sulfanyl}propan-2-yl]carbamate | 著者 | Sevrioukova, I. | 登録日 | 2020-11-28 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength. Int J Mol Sci, 22, 2021
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7LXL
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![BU of 7lxl by Molmil](/molmil-images/mine/7lxl) | Crystal structure of human CYP3A4 bound to the testosterone dimer | 分子名称: | 17alpha-hydroxy-7alpha-[(2Z)-4-(17beta-hydroxy-3-oxo-8alpha-androst-4-en-7beta-yl)but-2-en-1-yl]-8alpha,10alpha,13alpha,14beta-androst-4-en-3-one, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sevrioukova, I.F. | 登録日 | 2021-03-04 | 公開日 | 2021-04-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Innovative C 2 -symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4. Eur.J.Med.Chem., 220, 2021
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6L8H
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![BU of 6l8h by Molmil](/molmil-images/mine/6l8h) | Crystal structure of CYP97C1 | 分子名称: | Carotene epsilon-monooxygenase, chloroplastic, GLYCEROL, ... | 著者 | Niu, G, Guo, Q, Liu, L. | 登録日 | 2019-11-06 | 公開日 | 2020-06-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for plant lutein biosynthesis from alpha-carotene. Proc.Natl.Acad.Sci.USA, 117, 2020
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6LDL
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![BU of 6ldl by Molmil](/molmil-images/mine/6ldl) | Crystal structure of CYP116B46-N(20-445) from Tepidiphilus thermophilus in complex with HEME | 分子名称: | BICINE, Cytochrome P450, GLYCEROL, ... | 著者 | Zhang, L.L, Xie, Z.Z, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2019-11-21 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase. Nat Commun, 11, 2020
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1WIY
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![BU of 1wiy by Molmil](/molmil-images/mine/1wiy) | Crystal Structure Analysis of a 6-coordinated Cytochorome P450 from Thermus thermophilus HB8 | 分子名称: | Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Kousumi, Y, Nakagawa, N, Kaneko, M, Yamamoto, H, Masui, R, Kuramitsu, S, Ueyama, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-05-28 | 公開日 | 2004-11-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure Analysis of Cytochrome P450 from Thermus thermophilus HB8 To be Published
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6L8J
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![BU of 6l8j by Molmil](/molmil-images/mine/6l8j) | Crystal structure of CYP97A3 mutant S290D/W300L/S304V in complex with retinal | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Protein LUTEIN DEFICIENT 5, chloroplastic, ... | 著者 | Niu, G, Guo, Q, Liu, L. | 登録日 | 2019-11-06 | 公開日 | 2020-06-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.399 Å) | 主引用文献 | Structural basis for plant lutein biosynthesis from alpha-carotene. Proc.Natl.Acad.Sci.USA, 117, 2020
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6L1B
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![BU of 6l1b by Molmil](/molmil-images/mine/6l1b) | |
6L69
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![BU of 6l69 by Molmil](/molmil-images/mine/6l69) | |
6RQ5
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![BU of 6rq5 by Molmil](/molmil-images/mine/6rq5) | CYP121 in complex with 3,5-dimethyl dicyclotyrosine | 分子名称: | (3~{S},6~{S})-3-[(3,5-dimethyl-4-oxidanyl-phenyl)methyl]-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mycocyclosin synthase, ... | 著者 | Poddar, H, Levy, C. | 登録日 | 2019-05-15 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure-Activity Relationships of cyclo (l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct. J.Med.Chem., 62, 2019
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6RQ8
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![BU of 6rq8 by Molmil](/molmil-images/mine/6rq8) | CYP121 in complex with 3-iodo dicyclotyrosine | 分子名称: | (3~{S},6~{S})-3-[(4-hydroxyphenyl)methyl]-6-[(3-iodanyl-4-oxidanyl-phenyl)methyl]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mycocyclosin synthase, ... | 著者 | Poddar, H, Levy, C. | 登録日 | 2019-05-15 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Structure-Activity Relationships of cyclo (l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct. J.Med.Chem., 62, 2019
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6RQ0
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![BU of 6rq0 by Molmil](/molmil-images/mine/6rq0) | CYP121 in complex with 3-methyl dicyclotyrosine | 分子名称: | (3~{S},6~{S})-3-[(4-hydroxyphenyl)methyl]-6-[(3-methyl-4-oxidanyl-phenyl)methyl]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mycocyclosin synthase, ... | 著者 | Poddar, H, Levy, C. | 登録日 | 2019-05-15 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-Activity Relationships of cyclo (l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct. J.Med.Chem., 62, 2019
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6RQD
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![BU of 6rqd by Molmil](/molmil-images/mine/6rqd) | CYP121 in complex with 3-chloro dicyclotyrosine | 分子名称: | (3~{S},6~{S})-3-[(3-chloranyl-4-oxidanyl-phenyl)methyl]-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Poddar, H, Levy, C. | 登録日 | 2019-05-15 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | 主引用文献 | Structure-Activity Relationships of cyclo (l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct. J.Med.Chem., 62, 2019
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6RO8
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![BU of 6ro8 by Molmil](/molmil-images/mine/6ro8) | The crystal structure of Acinetobacter radioresistens CYP116B5 heme domain | 分子名称: | Cytochrome P450 RhF, HISTIDINE, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Ciaramella, A, Catucci, G, Gilardi, G, Di Nardo, G. | 登録日 | 2019-05-10 | 公開日 | 2019-08-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of bacterial CYP116B5 heme domain: New insights on class VII P450s structural flexibility and peroxygenase activity. Int.J.Biol.Macromol., 140, 2019
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6RQ1
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![BU of 6rq1 by Molmil](/molmil-images/mine/6rq1) | CYP121 in complex with 2-methyl dicyclotyrosine | 分子名称: | (3~{S},6~{S})-3-[(4-hydroxyphenyl)methyl]-6-[(2-methyl-4-oxidanyl-phenyl)methyl]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mycocyclosin synthase, ... | 著者 | Poddar, H, Levy, C. | 登録日 | 2019-05-15 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Structure-Activity Relationships of cyclo (l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct. J.Med.Chem., 62, 2019
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6RQB
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![BU of 6rqb by Molmil](/molmil-images/mine/6rqb) | CYP121 in complex with 3-bromo dicyclotyrosine | 分子名称: | 3-bromo dicyclotyrosine, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Poddar, H, Levy, C. | 登録日 | 2019-05-15 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.459 Å) | 主引用文献 | Structure-Activity Relationships of cyclo (l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct. J.Med.Chem., 62, 2019
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6M4Q
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![BU of 6m4q by Molmil](/molmil-images/mine/6m4q) | Cytochrome P450 monooxygenase StvP2 substrate-free structure | 分子名称: | Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. | 登録日 | 2020-03-08 | 公開日 | 2020-08-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nat Commun, 11, 2020
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6M4P
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![BU of 6m4p by Molmil](/molmil-images/mine/6m4p) | Cytochrome P450 monooxygenase StvP2 substrate-bound structure | 分子名称: | 6-methoxy-streptovaricin C, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. | 登録日 | 2020-03-08 | 公開日 | 2020-08-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nat Commun, 11, 2020
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6RQ6
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![BU of 6rq6 by Molmil](/molmil-images/mine/6rq6) | CYP121 in complex with 3-fluoro dicyclotyrosine | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-fluoro dicyclotyrosine, Mycocyclosin synthase, ... | 著者 | Poddar, H, Levy, C. | 登録日 | 2019-05-15 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Structure-Activity Relationships of cyclo (l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct. J.Med.Chem., 62, 2019
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6MA6
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![BU of 6ma6 by Molmil](/molmil-images/mine/6ma6) | |
1X8V
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![BU of 1x8v by Molmil](/molmil-images/mine/1x8v) | Estriol-bound and ligand-free structures of sterol 14alpha-demethylase (CYP51) | 分子名称: | Cytochrome P450 51, ESTRIOL, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Podust, L.M, Yermalitskaya, L.V, Lepesheva, G.I, Podust, V.N, Dalmasso, E.A, Waterman, M.R. | 登録日 | 2004-08-18 | 公開日 | 2004-11-23 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Estriol Bound and Ligand-free Structures of Sterol 14alpha-Demethylase. Structure, 12, 2004
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6MA7
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![BU of 6ma7 by Molmil](/molmil-images/mine/6ma7) | Human CYP3A4 bound to an inhibitor fluconazole | 分子名称: | 1,2-ETHANEDIOL, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, Cytochrome P450 3A4, ... | 著者 | Sevrioukova, I.F. | 登録日 | 2018-08-26 | 公開日 | 2019-01-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules. Biochemistry, 58, 2019
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6M4S
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![BU of 6m4s by Molmil](/molmil-images/mine/6m4s) | Crystal Structure Analysis of the cytochrome P450 CYP-Sb21 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Cytochrome P450 hydroxylase sb21, ... | 著者 | Li, F.W, Li, S.Y. | 登録日 | 2020-03-09 | 公開日 | 2021-02-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana . Synth Syst Biotechnol, 5, 2020
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