6MA7

Human CYP3A4 bound to an inhibitor metyrapone

Summary for 6MA7

DescriptorCytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (6 entities in total)
Functional Keywordsoxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, cyp3a4, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight56822.74
Authors
Sevrioukova, I.F. (deposition date: 2018-08-26, release date: 2019-01-16)
Primary citation
Sevrioukova, I.F.
Interaction of human drug-metabolizing CYP3A4 with small inhibitory molecules
Biochemistry, 2019
Experimental method
X-RAY DIFFRACTION (2.09 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25911 0.4% 1.4% 4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6ma7
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Molmil generated image of 6ma7
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Molmil generated image of 6ma7
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More Biological unit images

Molmil generated image of 6ma7
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Molmil generated image of 6ma7
rotated about x axis by 90°
Molmil generated image of 6ma7
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6ma7.pdb1.gz [334.91 KB])
Coordinate files for Biological unit (6ma7.pdb2.gz [667.94 KB])
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